Table 4 Potential PKA targets showing... | American Society of Hematology

Table 4

Potential PKA targets showing early responses 10 seconds after both 2nM and 5nM iloprost treatment

Accession	Gene	Protein name	Putative PKA site	Accession	Gene	Protein name	Putative PKA site
O14828	SCAMP3	Secretory carrier–associated membrane protein 3	S32	Q8N4C8	MNK1	Misshapen-like kinase 1	S699 and S701
O00501	CLDN5	Claudin-5	T207	Q8N5J2	FAM63A	Protein FAM63A	S441
O43312	MTSS1	Metastasis suppressor protein 1	S272	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	S886
O43768	ENSA	α-endosulfine	S109	Q93100	PHKB	Phosphorylase b kinase regulatory subunit β	S27
O94929	ABLIM3	Actin-binding LIM protein 3	S277	Q96MK2	FAM65C	Protein FAM65C	S340*
O95644	NFATC1	Nuclear factor of activated T cells, cytoplasmic 1	S245	Q99490	AGAP2	Arf-GAP with GTPase, ANK repeat and PH domain–containing protein 2	T647
O95819	MAP4K4	Mitogen-activated protein kinase kinase kinase kinase 4	S900*	Q9BZ72	PTTPNM2	Membrane-associated phosphatidylinositol transfer protein 2	S1277
P16150	SPN	Leukosialin	T341	Q9C0C9	UBE2O	Ubiquitin-conjugating enzyme E2 O	S515
P56211	ARPP19	cAMP-regulated phosphoprotein 19	S104	Q9P270	SLAIN2	SLAIN motif-containing protein 2	S391
Q14162	SCARF1	Endothelial cells scavenger receptor	S589 and S605	Q9UBW5	BIN2	Bridging integrator 2	S259
Q14432	PDE3A	cGMP-inhibited 3′,5′-cyclic phosphodiesterase A	S312	Q9UJU6	DBNL	Drebrin-like protein	S269*
Q15149	PLEC	Plectin	S4386	Q9UKE5	TNIK	TRAF2 and NCK-interacting protein kinase	S1021*
Q684P5	RAP1GAP2	Rap1 GTPase-activathg protein 2	S7	Q9Y2J2	EPB41L3	Band 4.1-like protein 3	S420
Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	S116, 117, and S587	Q9Y385	UBE2J1	Ubiquitin-conjugating enzyme E2 J1	S266
Q8IWB9	TEX2	Testis-expressed sequence 2 protein	S295	Q9Y6F6	MRVI1	Protein MRVI1	S657 and S670

Accession	Gene	Protein name	Putative PKA site	Accession	Gene	Protein name	Putative PKA site
O14828	SCAMP3	Secretory carrier–associated membrane protein 3	S32	Q8N4C8	MNK1	Misshapen-like kinase 1	S699 and S701
O00501	CLDN5	Claudin-5	T207	Q8N5J2	FAM63A	Protein FAM63A	S441
O43312	MTSS1	Metastasis suppressor protein 1	S272	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	S886
O43768	ENSA	α-endosulfine	S109	Q93100	PHKB	Phosphorylase b kinase regulatory subunit β	S27
O94929	ABLIM3	Actin-binding LIM protein 3	S277	Q96MK2	FAM65C	Protein FAM65C	S340*
O95644	NFATC1	Nuclear factor of activated T cells, cytoplasmic 1	S245	Q99490	AGAP2	Arf-GAP with GTPase, ANK repeat and PH domain–containing protein 2	T647
O95819	MAP4K4	Mitogen-activated protein kinase kinase kinase kinase 4	S900*	Q9BZ72	PTTPNM2	Membrane-associated phosphatidylinositol transfer protein 2	S1277
P16150	SPN	Leukosialin	T341	Q9C0C9	UBE2O	Ubiquitin-conjugating enzyme E2 O	S515
P56211	ARPP19	cAMP-regulated phosphoprotein 19	S104	Q9P270	SLAIN2	SLAIN motif-containing protein 2	S391
Q14162	SCARF1	Endothelial cells scavenger receptor	S589 and S605	Q9UBW5	BIN2	Bridging integrator 2	S259
Q14432	PDE3A	cGMP-inhibited 3′,5′-cyclic phosphodiesterase A	S312	Q9UJU6	DBNL	Drebrin-like protein	S269*
Q15149	PLEC	Plectin	S4386	Q9UKE5	TNIK	TRAF2 and NCK-interacting protein kinase	S1021*
Q684P5	RAP1GAP2	Rap1 GTPase-activathg protein 2	S7	Q9Y2J2	EPB41L3	Band 4.1-like protein 3	S420
Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	S116, 117, and S587	Q9Y385	UBE2J1	Ubiquitin-conjugating enzyme E2 J1	S266
Q8IWB9	TEX2	Testis-expressed sequence 2 protein	S295	Q9Y6F6	MRVI1	Protein MRVI1	S657 and S670

Phosphorylation could not be confidently localized within the peptide sequence.