Protein functions which are significantly enriched within the 299 regulated proteins
| Enriched protein function (P value of enrichment) . | All proteins . | Potentially PKA regulated . | Early responders, 10 s, 2nM/5 nM . |
|---|---|---|---|
| Actin binding (1.6 × 10−11) | 26 | 17 | 7/8 |
| Small GTPase regulator activity (1.7 × 10−10) | 22 | 10 | 12/7 |
| Calmodulin binding (8.6 × 10−9) | 16 | 7 | 3/3 |
| SH3/SH2 adaptor activity (1.9 × 10−4) | 6 | 3 | 1/1 |
| Ubiquitin ligase binding (1.8 × 10−3) | 5 | 3 | 0/2 |
| Serine/threonine kinase activity (4.4 × 10−3) | 12 | 5 | 2/4 |
| Ubiquitin protein ligase activity (8.2 × 10−2) | 4 | 2 | 3/2 |
| Tyrosine kinase activity (9.0 × 10−2) | 4 | 0 | 0/2 |
| Enriched protein function (P value of enrichment) . | All proteins . | Potentially PKA regulated . | Early responders, 10 s, 2nM/5 nM . |
|---|---|---|---|
| Actin binding (1.6 × 10−11) | 26 | 17 | 7/8 |
| Small GTPase regulator activity (1.7 × 10−10) | 22 | 10 | 12/7 |
| Calmodulin binding (8.6 × 10−9) | 16 | 7 | 3/3 |
| SH3/SH2 adaptor activity (1.9 × 10−4) | 6 | 3 | 1/1 |
| Ubiquitin ligase binding (1.8 × 10−3) | 5 | 3 | 0/2 |
| Serine/threonine kinase activity (4.4 × 10−3) | 12 | 5 | 2/4 |
| Ubiquitin protein ligase activity (8.2 × 10−2) | 4 | 2 | 3/2 |
| Tyrosine kinase activity (9.0 × 10−2) | 4 | 0 | 0/2 |
Protein functions which are significantly enriched within the 299 regulated proteins, according to GO annotation.13 Given is the number of (1) proteins which can be assigned to the respective function from all regulated proteins, (2) potentially PKA-phosphorylated proteins (according to GPS 2.1 consensus motif prediction) as well as (3) early responders which show significant regulation already 10 seconds after stimulation.