Selection of significantly enriched biological processes
| Enriched biological process (P value of enrichment) . | All proteins . | Potentially PKA regulated . | Early responders (10 s), 2nM/5 nM . |
|---|---|---|---|
| Vesicle-mediated transport (1.1 × 10−20) | 54 | 19 | 14/14 |
| Platelet activation (4.4 × 10−12) | 22 | 6 | 5/7 |
| Actin cytoskeleton organization (1.5 × 10−12) | 26 | 15 | 11/10 |
| Regulation of small GTPase–mediated signal transduction (5.5 × 10−12) | 26 | 13 | 10/9 |
| Platelet degranulation (1.5 × 10−8) | 12 | 2 | 3/3 |
| Negative regulation of cytoskeleton organization (3.7 × 10−7) | 10 | 6 | 2/3 |
| Blood coagulation (1.5 × 10−6) | 28 | 8 | 7/9 |
| Regulation of Ras protein signal transduction (4.8 × 10−5) | 21 | 8 | 8/4 |
| Cell-surface receptor linked signaling pathway (1.9 × 10−2) | 42 | 24 | 11/12 |
| Enriched biological process (P value of enrichment) . | All proteins . | Potentially PKA regulated . | Early responders (10 s), 2nM/5 nM . |
|---|---|---|---|
| Vesicle-mediated transport (1.1 × 10−20) | 54 | 19 | 14/14 |
| Platelet activation (4.4 × 10−12) | 22 | 6 | 5/7 |
| Actin cytoskeleton organization (1.5 × 10−12) | 26 | 15 | 11/10 |
| Regulation of small GTPase–mediated signal transduction (5.5 × 10−12) | 26 | 13 | 10/9 |
| Platelet degranulation (1.5 × 10−8) | 12 | 2 | 3/3 |
| Negative regulation of cytoskeleton organization (3.7 × 10−7) | 10 | 6 | 2/3 |
| Blood coagulation (1.5 × 10−6) | 28 | 8 | 7/9 |
| Regulation of Ras protein signal transduction (4.8 × 10−5) | 21 | 8 | 8/4 |
| Cell-surface receptor linked signaling pathway (1.9 × 10−2) | 42 | 24 | 11/12 |
Selection of significantly enriched biological processes, according to gene ontology (GO) annotation,13 within the regulated proteins. Given is the number of proteins which can be assigned to the respective biological process from the share of all regulated proteins, the potentially PKA-regulated proteins as well as the early responders which show significant regulation already 10 seconds after stimulation.