A panel of 6 metabolites with prognostic value for CN-AML
| Metabolite‡ . | Importance score for OS and EFS* . | Regression weight† . | Median, range, µg/mL . |
|---|---|---|---|
| Lactate | 74.17 | −0.67 | 3 393.09 (444.08-15 073.18) |
| 2-Oxoglutarate | 57.12 | −0.51 | 1.34 (1.20-1.44) |
| Pyruvate | 53.89 | −0.48 | 0.53 (0-54.84) |
| 2-HG | 12.3 | −0.11 | 3.63 (3.54-530.60) |
| Glycerol-3-phosphate | 8.05 | −0.07 | 0.76 (0.66-1.51) |
| Citrate | −23.54 | 0.21 | 2.57 (0.80-6.23) |
| Metabolite‡ . | Importance score for OS and EFS* . | Regression weight† . | Median, range, µg/mL . |
|---|---|---|---|
| Lactate | 74.17 | −0.67 | 3 393.09 (444.08-15 073.18) |
| 2-Oxoglutarate | 57.12 | −0.51 | 1.34 (1.20-1.44) |
| Pyruvate | 53.89 | −0.48 | 0.53 (0-54.84) |
| 2-HG | 12.3 | −0.11 | 3.63 (3.54-530.60) |
| Glycerol-3-phosphate | 8.05 | −0.07 | 0.76 (0.66-1.51) |
| Citrate | −23.54 | 0.21 | 2.57 (0.80-6.23) |
PRS of each sample is calculated according to followed equation: PRS = (−0.67) × lactate + (−0.51) × 2-oxoglutarate + (−0.48) × pyruvate + (−0.11) × 2-HG + (−0.07) × glycerol-3-phosphate + 0.21 × citrate.
Importance score was computed by means of the SuperPC algorithm. Negative score means that increasing in value of metabolite indicates better survival, whereas positive score means that increasing in value of metabolite indicates worse survival.
The weight of the first principal component in PCA model.
Metabolites are confirmed by standards.