Frequency of SH2B3 c.784T>C in MPNs vs controls, MPNs JAK2V617F vs controls, MPNs JAK2V617F vs MPNs JAK2WT, and MF JAK2V617F vs controls
| . | Frequency, n(%) . | OR . | 95% CI . | χ2 (df = 1) . | P value . | |
|---|---|---|---|---|---|---|
| Allele | MPNs (n = 317) | Controls* (n = 2851) | ||||
| Allele 784C | 312 (49.2) | 3201 (56.1) | 1.00 (reference) | |||
| Allele 784T | 322 (50.8) | 2501 (43.9) | 1.32 | 1.12-1.56 | 11.15 | 8.0 × 10−4 |
| Allele | Jak2 V617F (n = 184) | Controls* (n = 2851) | ||||
| Allele 784C | 159 (43.2) | 3201 (56.1) | 1.00 (reference) | |||
| Allele 784T | 209 (56.8) | 2501 (43.9) | 1.68 | 1.36-2.08 | 23.47 | 1.0 × 10−4 |
| Allele | Jak2 V617F (n = 184) | Jak2 WT (n = 133) | ||||
| Allele 784C | 159 (43.2) | 153 (57.5) | 1.00 (reference) | |||
| Allele 784T | 209 (56.8) | 113 (42.5) | 1.78 | 1.29-2.45 | 12.65 | 4 × 10−4 |
| Allele | MF Jak2V617F (n = 81) | Controls* (n = 2851) | ||||
| Allele 784C | 59 (36.4) | 3201 (56.1) | 1.00 (reference) | |||
| Allele 784T | 103 (63.6) | 2501 (43.9) | 2.23 | 1.61-3.08 | 24.81 | 1.0 × 10−4 |
| . | Frequency, n(%) . | OR . | 95% CI . | χ2 (df = 1) . | P value . | |
|---|---|---|---|---|---|---|
| Allele | MPNs (n = 317) | Controls* (n = 2851) | ||||
| Allele 784C | 312 (49.2) | 3201 (56.1) | 1.00 (reference) | |||
| Allele 784T | 322 (50.8) | 2501 (43.9) | 1.32 | 1.12-1.56 | 11.15 | 8.0 × 10−4 |
| Allele | Jak2 V617F (n = 184) | Controls* (n = 2851) | ||||
| Allele 784C | 159 (43.2) | 3201 (56.1) | 1.00 (reference) | |||
| Allele 784T | 209 (56.8) | 2501 (43.9) | 1.68 | 1.36-2.08 | 23.47 | 1.0 × 10−4 |
| Allele | Jak2 V617F (n = 184) | Jak2 WT (n = 133) | ||||
| Allele 784C | 159 (43.2) | 153 (57.5) | 1.00 (reference) | |||
| Allele 784T | 209 (56.8) | 113 (42.5) | 1.78 | 1.29-2.45 | 12.65 | 4 × 10−4 |
| Allele | MF Jak2V617F (n = 81) | Controls* (n = 2851) | ||||
| Allele 784C | 59 (36.4) | 3201 (56.1) | 1.00 (reference) | |||
| Allele 784T | 103 (63.6) | 2501 (43.9) | 2.23 | 1.61-3.08 | 24.81 | 1.0 × 10−4 |
CI, confidence interval; df, degrees of freedom; MF, myelofibrosis; WT, wild-type.
Alcina et al, 2010.9