Depletion of Ph+ LTC-IC colonies by CSL362-mediated ADCC
| Patient . | 0 µg/mL CSL362 . | 1 µg/mL CSL362 . | Ph+ LTC-IC colonies depleted . | ||
|---|---|---|---|---|---|
| LTC-IC colony number (% Ph+) . | Calculated Ph+ LTC-IC colony number . | LTC-IC colony number (% Ph+) . | Calculated Ph+ LTC-IC colony number . | ||
| CP-CML 1 | 163 (67%) | 109 | 26 (36%) | 9 | 100 (91.7%) |
| CP-CML 4 | 312 (99%) | 312 | 48 (100%) | 48 | 264 (84.6%) |
| CP-CML 5 | 74 (63%) | 47 | 34 (9%) | 4 | 43 (91.5%) |
| Patient . | 0 µg/mL CSL362 . | 1 µg/mL CSL362 . | Ph+ LTC-IC colonies depleted . | ||
|---|---|---|---|---|---|
| LTC-IC colony number (% Ph+) . | Calculated Ph+ LTC-IC colony number . | LTC-IC colony number (% Ph+) . | Calculated Ph+ LTC-IC colony number . | ||
| CP-CML 1 | 163 (67%) | 109 | 26 (36%) | 9 | 100 (91.7%) |
| CP-CML 4 | 312 (99%) | 312 | 48 (100%) | 48 | 264 (84.6%) |
| CP-CML 5 | 74 (63%) | 47 | 34 (9%) | 4 | 43 (91.5%) |