Clinical characteristics and distal radius bone parameters (derived using the extended cortical bone analysis and µFEA of HRpQCT images) in MGUS patients and matched control subjects
| . | MGUS (n = 50) . | Control (n = 100) . | P value . |
|---|---|---|---|
| Clinical characteristics | |||
| Male, n (%) | 30 (60%) | 60 (60%) | |
| Age (y) | 70.5 ± 1.4 | 70.3 ± 1.0 | .878 |
| Height (cm) | 171 ± 1.5 | 170 ± 0.9 | .763 |
| Weight (kg) | 82.2 ± 2.3 | 83.0 ± 1.6 | .789 |
| BMI (kg/m2) | 28.2 ± 0.7 | 28.6 ± 0.4 | .622 |
| Cortical bone parameters (derived by HRpQCT) | |||
| Cortical porosity (%) | 2.91 ± 0.19 | 2.46 ± 0.13 | .048 |
| Cortical pore volume (mm3) | 17.3 ± 1.2 | 14.8 ± 0.8 | .087 |
| Cortical vBMD (mg/cm3) | 907 ± 8.0 | 949 ± 5.7 | <.001 |
| Cortical thickness (mm) | 0.990 ± 0.030 | 1.058 ± 0.021 | .067 |
| Biomechanical bone strength (derived by µFEA) | |||
| Failure load (N) | 4049 ± 112 | 4215 ± 79 | .230 |
| Stiffness (kN/mm) | 80 ± 2.3 | 84 ± 1.6 | .189 |
| Apparent modulus (MPa) | 1768 ± 67 | 1933 ± 47 | .045 |
| . | MGUS (n = 50) . | Control (n = 100) . | P value . |
|---|---|---|---|
| Clinical characteristics | |||
| Male, n (%) | 30 (60%) | 60 (60%) | |
| Age (y) | 70.5 ± 1.4 | 70.3 ± 1.0 | .878 |
| Height (cm) | 171 ± 1.5 | 170 ± 0.9 | .763 |
| Weight (kg) | 82.2 ± 2.3 | 83.0 ± 1.6 | .789 |
| BMI (kg/m2) | 28.2 ± 0.7 | 28.6 ± 0.4 | .622 |
| Cortical bone parameters (derived by HRpQCT) | |||
| Cortical porosity (%) | 2.91 ± 0.19 | 2.46 ± 0.13 | .048 |
| Cortical pore volume (mm3) | 17.3 ± 1.2 | 14.8 ± 0.8 | .087 |
| Cortical vBMD (mg/cm3) | 907 ± 8.0 | 949 ± 5.7 | <.001 |
| Cortical thickness (mm) | 0.990 ± 0.030 | 1.058 ± 0.021 | .067 |
| Biomechanical bone strength (derived by µFEA) | |||
| Failure load (N) | 4049 ± 112 | 4215 ± 79 | .230 |
| Stiffness (kN/mm) | 80 ± 2.3 | 84 ± 1.6 | .189 |
| Apparent modulus (MPa) | 1768 ± 67 | 1933 ± 47 | .045 |
Values are presented as percentage or mean ± SE and P values. Comparisons of bone parameters are adjusted for age and gender.
MPa, megapascal; SE, standard error.