Patient characteristics at diagnosis
| . | Number (%) . | P value . | |||||
|---|---|---|---|---|---|---|---|
| Preimatinib cohort (N = 266) . | Imatinib cohort . | ||||||
| Any imatinib (N = 175) . | Late imatinib (N = 86) . | Early imatinib (N = 89) . | Preimatinib vs any imatinib . | Late vs early imatinib . | Pre vs late vs early imatinib (trend) . | ||
| Sex | |||||||
| Male | 149 (56) | 110 (63) | 54 (63) | 56 (63) | P = .2 | P = .9 | P = .2 |
| Female | 117 (44) | 65 (37) | 32 (37) | 33 (37) | |||
| WBC ×109/l | |||||||
| Unknown | 2 (1) | 0 | 0 | 0 | |||
| <30 | 140 (52) | 96 (55) | 46 (53) | 50 (56) | P = .7 | P = .7 | P = .6 |
| ≥30 | 124 (47) | 79 (45) | 40 (47) | 39 (44) | |||
| Median (range) | 26.8 (1.5-438) | 21.0 (0.5-491) | 22.1 (0.5-491) | 21.0 (0.8-372.3) | P = .4 | P = .8 | P = .4 |
| Age (years) | |||||||
| <30 | 65 (24) | 38 (22) | 17 (20) | 21 (24) | P = .0007 | P = .8 | P = .002 |
| 30-49 | 155 (58) | 75 (43) | 39 (45) | 36 (40) | |||
| ≥50 | 46 (17) | 62 (35) | 30 (35) | 32 (36) | |||
| Median (range) | 40 (15-60) | 42 (16-64) | 43 (16-63) | 42 (16-64) | P = .002 | P = .9 | P = .003 |
| CNS disease | |||||||
| Yes | 14 (5) | 3 (2) | 3 (3) | 0 (0) | P = .06 | P = .08 | P = .03 |
| No/unknown | 252 (95) | 172 (98) | 83 (97) | 89 (100) | |||
| . | Number (%) . | P value . | |||||
|---|---|---|---|---|---|---|---|
| Preimatinib cohort (N = 266) . | Imatinib cohort . | ||||||
| Any imatinib (N = 175) . | Late imatinib (N = 86) . | Early imatinib (N = 89) . | Preimatinib vs any imatinib . | Late vs early imatinib . | Pre vs late vs early imatinib (trend) . | ||
| Sex | |||||||
| Male | 149 (56) | 110 (63) | 54 (63) | 56 (63) | P = .2 | P = .9 | P = .2 |
| Female | 117 (44) | 65 (37) | 32 (37) | 33 (37) | |||
| WBC ×109/l | |||||||
| Unknown | 2 (1) | 0 | 0 | 0 | |||
| <30 | 140 (52) | 96 (55) | 46 (53) | 50 (56) | P = .7 | P = .7 | P = .6 |
| ≥30 | 124 (47) | 79 (45) | 40 (47) | 39 (44) | |||
| Median (range) | 26.8 (1.5-438) | 21.0 (0.5-491) | 22.1 (0.5-491) | 21.0 (0.8-372.3) | P = .4 | P = .8 | P = .4 |
| Age (years) | |||||||
| <30 | 65 (24) | 38 (22) | 17 (20) | 21 (24) | P = .0007 | P = .8 | P = .002 |
| 30-49 | 155 (58) | 75 (43) | 39 (45) | 36 (40) | |||
| ≥50 | 46 (17) | 62 (35) | 30 (35) | 32 (36) | |||
| Median (range) | 40 (15-60) | 42 (16-64) | 43 (16-63) | 42 (16-64) | P = .002 | P = .9 | P = .003 |
| CNS disease | |||||||
| Yes | 14 (5) | 3 (2) | 3 (3) | 0 (0) | P = .06 | P = .08 | P = .03 |
| No/unknown | 252 (95) | 172 (98) | 83 (97) | 89 (100) | |||
CNS, central nervous system.