CN and cytogenetic aberrations of the 12 cases of MYC-negative B-cell lymphomas and SU-DHL-5 and HT cell lines (cohort 2)
| Case no. . | Large CN alterations (>4Mb) . | Karyotype . | t(8;14) . | MYC BAP/ IGH BAP . | MYC BAP 1/2 . | BCL2/ MALT1 BAP . | CEP11/ATM/ FDX . | CEP11/11qter . | CCND1 BAP . |
|---|---|---|---|---|---|---|---|---|---|
| Case 1 | Gains (7q34-qter, 8q23.1-q24.22, 11q12.2-q23.3, 13q22.3-q33.2, 18q12.3-q21.1); ampl (12q12-q13.12, 18q21.1-q22.1); losses (4q21.21-q22.1, 6q13-q22.2, 11q23.3-qter, 13q33.2-qter, 18q22.1-q23) | 46,XY,del(6)(q14q24),add(7)(p21),dup(11) (q13q23),t(12;18)(q12;q23),ins(18;?)(q21;?)[18] | – | – | – (3 copies) | CEP11x2;ATM x3;FDXx3 | |||
| Case 2 | Gains (11q12.1-q23.2); ampl (11q23.3-qter); losses (10q23.2-q23.32, 11q23.3-qter) | 46,XY,?dup(11)(q12q23),der(18)?t(13;18)(q21;q21)[15] | – | – | –/– | – | CEP11x2; ATMx2;FDXx2 | ||
| Case 3 | Gains (3p26.3-q13.11, 3q22.1-q29, 10q24.32-q26.3, 18q21.1-q23); ampl(3q12.1-q13.11); losses (3q13.11-q22.1, 6q14.3-q24.2, 11q23.3-q25, Xp22.33-qter) | 47,X,-X,+3,add(3)(q11)x2,t(6;10)(p22;q22),der(6)t(6;10)(p22;q22)del(6)(q12q23),add(11) (q23),+mar [12]/46,idem,t(9;13)q10;p10),-mar[5] | – | – | –/– | CEP11x2; ATMx2;FDXx2 | |||
| Case 4 | Gains (11q13.4-q23.3); losses (11q23.3-qter) | 46,XY,dup(11)(q23q13) [20] | – | – | CEP11x2; ATMx3;FDXx3 | CEP11x2 11qterx1 | |||
| Case 5 | Gains (7q34-qter, 11q13.4-q24.1,12); losses (11q24.1-qter) | 46–47,XY,dup(11)(q23q13)-13,+1∼2mar[15]/46-47,sl, +add(8)(p21),+der(14)t(4;14)(q31;q13),add(18)(q22)[cp5] | – | – | |||||
| Case 6 | Gains (11q13.1-q23.3, 19p13.3-p13.2); ampl (11q23.3); losses (11q23.3-qter) | 46,XY,dup(11)(q23q13)[9] | –/+ | – | CEP11x2; ATMx3;FDXx3 | CEP11x2 11qterx1 | CCND1x3 | ||
| Case 7 | Gains (11q13.1-q24.1, 12); losses (11q24.1-qter) | 47,XX,dup(11)(q23q13), +12[cp21] | –/+ | – | CEP11x2 11qterx1 | CCND1x3 | |||
| Case 8 | Gain (7q31.1-qter; 11q12.1-q24.2; 12pter-p12.2; 12p12.1-qter); losses (9q21.11-q31.1; 11q24.2-qter) | 47,XY,del(9)(q22q34), der(11)(11pter->11q23::?11q23->11q11:?),+12[7]/47,sl,add(17)(p11)[2] | – | ||||||
| Case 9 | Gain (11q13.1-q23.3); ampl (11q14.3-q23.3); losses (2q14.3-q31.1; 11q23.3-qter) | na | – | – | –/– | ATMx4-5;FDXx4-5 | |||
| Case 10 | Gain (10; 11q12.1-q23.3; 11q23.3); losses (11q23.3-qter) | na | –/– | – | |||||
| Case 11 | Gain (8q24.13-q24.23; 11q13.1-q23.3); losses(7q11.21-q11.22; 7q11.22-q11.23; 11q23.3-qter) | 46, XY,add(11)(q23)[6]/46,XY[14] | – | – | –/– | – | CEP11X2 11qterx1 | ||
| Case 12 | Gain (11q12.1-q22.3); losses (11q22.3-qter) | na | – | – | – | CEP11X2 11qterx1 | |||
| SU-DHL-5 | Gains (11q23.2-q23.3, 12pter-q13, 19pter-p13.2); losses (6pter-p22.1, 6q13-qter, 11q23.3-qter) | 47,XX,add(6)(p21),del(6)(q13),+12,del(12)(q12) | – | – | –/– | – | |||
| HT | Gain (10q21.1-q22.2, 11q22.3-q23.2); ampl 11q22.3-q23.2; 11q23.2-q23.3); losses (2p25.3-p24.1, 2p22.3-p16.2, 2p16.1-p15, 2p15-p12, 2q13-q24.1, 4pter-p12, 11q23.3-qter) | 46(42-46)<2n>XY,+2, der(2;4)(p10;q10), der(2)(del)(2)(p11?q21), dup(10)(q11q22-23), dup(11)(?q23qter) | – | – | –/– | – |
| Case no. . | Large CN alterations (>4Mb) . | Karyotype . | t(8;14) . | MYC BAP/ IGH BAP . | MYC BAP 1/2 . | BCL2/ MALT1 BAP . | CEP11/ATM/ FDX . | CEP11/11qter . | CCND1 BAP . |
|---|---|---|---|---|---|---|---|---|---|
| Case 1 | Gains (7q34-qter, 8q23.1-q24.22, 11q12.2-q23.3, 13q22.3-q33.2, 18q12.3-q21.1); ampl (12q12-q13.12, 18q21.1-q22.1); losses (4q21.21-q22.1, 6q13-q22.2, 11q23.3-qter, 13q33.2-qter, 18q22.1-q23) | 46,XY,del(6)(q14q24),add(7)(p21),dup(11) (q13q23),t(12;18)(q12;q23),ins(18;?)(q21;?)[18] | – | – | – (3 copies) | CEP11x2;ATM x3;FDXx3 | |||
| Case 2 | Gains (11q12.1-q23.2); ampl (11q23.3-qter); losses (10q23.2-q23.32, 11q23.3-qter) | 46,XY,?dup(11)(q12q23),der(18)?t(13;18)(q21;q21)[15] | – | – | –/– | – | CEP11x2; ATMx2;FDXx2 | ||
| Case 3 | Gains (3p26.3-q13.11, 3q22.1-q29, 10q24.32-q26.3, 18q21.1-q23); ampl(3q12.1-q13.11); losses (3q13.11-q22.1, 6q14.3-q24.2, 11q23.3-q25, Xp22.33-qter) | 47,X,-X,+3,add(3)(q11)x2,t(6;10)(p22;q22),der(6)t(6;10)(p22;q22)del(6)(q12q23),add(11) (q23),+mar [12]/46,idem,t(9;13)q10;p10),-mar[5] | – | – | –/– | CEP11x2; ATMx2;FDXx2 | |||
| Case 4 | Gains (11q13.4-q23.3); losses (11q23.3-qter) | 46,XY,dup(11)(q23q13) [20] | – | – | CEP11x2; ATMx3;FDXx3 | CEP11x2 11qterx1 | |||
| Case 5 | Gains (7q34-qter, 11q13.4-q24.1,12); losses (11q24.1-qter) | 46–47,XY,dup(11)(q23q13)-13,+1∼2mar[15]/46-47,sl, +add(8)(p21),+der(14)t(4;14)(q31;q13),add(18)(q22)[cp5] | – | – | |||||
| Case 6 | Gains (11q13.1-q23.3, 19p13.3-p13.2); ampl (11q23.3); losses (11q23.3-qter) | 46,XY,dup(11)(q23q13)[9] | –/+ | – | CEP11x2; ATMx3;FDXx3 | CEP11x2 11qterx1 | CCND1x3 | ||
| Case 7 | Gains (11q13.1-q24.1, 12); losses (11q24.1-qter) | 47,XX,dup(11)(q23q13), +12[cp21] | –/+ | – | CEP11x2 11qterx1 | CCND1x3 | |||
| Case 8 | Gain (7q31.1-qter; 11q12.1-q24.2; 12pter-p12.2; 12p12.1-qter); losses (9q21.11-q31.1; 11q24.2-qter) | 47,XY,del(9)(q22q34), der(11)(11pter->11q23::?11q23->11q11:?),+12[7]/47,sl,add(17)(p11)[2] | – | ||||||
| Case 9 | Gain (11q13.1-q23.3); ampl (11q14.3-q23.3); losses (2q14.3-q31.1; 11q23.3-qter) | na | – | – | –/– | ATMx4-5;FDXx4-5 | |||
| Case 10 | Gain (10; 11q12.1-q23.3; 11q23.3); losses (11q23.3-qter) | na | –/– | – | |||||
| Case 11 | Gain (8q24.13-q24.23; 11q13.1-q23.3); losses(7q11.21-q11.22; 7q11.22-q11.23; 11q23.3-qter) | 46, XY,add(11)(q23)[6]/46,XY[14] | – | – | –/– | – | CEP11X2 11qterx1 | ||
| Case 12 | Gain (11q12.1-q22.3); losses (11q22.3-qter) | na | – | – | – | CEP11X2 11qterx1 | |||
| SU-DHL-5 | Gains (11q23.2-q23.3, 12pter-q13, 19pter-p13.2); losses (6pter-p22.1, 6q13-qter, 11q23.3-qter) | 47,XX,add(6)(p21),del(6)(q13),+12,del(12)(q12) | – | – | –/– | – | |||
| HT | Gain (10q21.1-q22.2, 11q22.3-q23.2); ampl 11q22.3-q23.2; 11q23.2-q23.3); losses (2p25.3-p24.1, 2p22.3-p16.2, 2p16.1-p15, 2p15-p12, 2q13-q24.1, 4pter-p12, 11q23.3-qter) | 46(42-46)<2n>XY,+2, der(2;4)(p10;q10), der(2)(del)(2)(p11?q21), dup(10)(q11q22-23), dup(11)(?q23qter) | – | – | –/– | – |
–, negative; +, positive; BAP, break apart.
Bold indicates chromosomal alterations that involve chromosome 11.