Calculation strategy for cause-specific attribution of overall anemia envelope
| Causes for which allocation of the anemia envelope was based on prevalence results from GBD 2010* |
| Malaria |
| Hookworm |
| Schistosomiasis |
| Peptic ulcer disease |
| Gastritis and duodenitis |
| Maternal hemorrhage |
| Sickle cell disorders |
| Homozygous sickle cell disease (HbS-HbS) |
| Heterozygous sickle cell disease (HbS-HbA) |
| Compound heterozygous sickle cell disease |
| Compound heterozygous sickle cell disease-thalassemia (HbS-Hbβ) |
| G6PD deficiency |
| Homozygous class I |
| Homozygous class II |
| Heterozygous (female only) |
| Thalassemias |
| β thalassemia major (Hbβ-Hbβ) |
| Heterozygous β thalassemia (Hbβ-HbA) |
| Compound heterozygous “E-β” thalassemia l (HbE-Hbβ) |
| Heterozygous hemoglobin E (HbE-normal) |
| Hemoglobin H disease (genotype = [- - / - alpha]) |
| CKD |
| Due to diabetes mellitus |
| Due to hypertension |
| Other and unspecified |
| Causes for which allocation of anemia envelope was based on systematic redistribution methods* |
| IDA |
| Other infectious diseases |
| Other neglected tropical diseases |
| Other hemoglobinopathies and hemolytic anemias |
| Uterine fibroids |
| Other gynecologic disorders |
| Other endocrine, nutrition, blood, and immune disorders |
| Causes for which allocation of the anemia envelope was based on prevalence results from GBD 2010* |
| Malaria |
| Hookworm |
| Schistosomiasis |
| Peptic ulcer disease |
| Gastritis and duodenitis |
| Maternal hemorrhage |
| Sickle cell disorders |
| Homozygous sickle cell disease (HbS-HbS) |
| Heterozygous sickle cell disease (HbS-HbA) |
| Compound heterozygous sickle cell disease |
| Compound heterozygous sickle cell disease-thalassemia (HbS-Hbβ) |
| G6PD deficiency |
| Homozygous class I |
| Homozygous class II |
| Heterozygous (female only) |
| Thalassemias |
| β thalassemia major (Hbβ-Hbβ) |
| Heterozygous β thalassemia (Hbβ-HbA) |
| Compound heterozygous “E-β” thalassemia l (HbE-Hbβ) |
| Heterozygous hemoglobin E (HbE-normal) |
| Hemoglobin H disease (genotype = [- - / - alpha]) |
| CKD |
| Due to diabetes mellitus |
| Due to hypertension |
| Other and unspecified |
| Causes for which allocation of anemia envelope was based on systematic redistribution methods* |
| IDA |
| Other infectious diseases |
| Other neglected tropical diseases |
| Other hemoglobinopathies and hemolytic anemias |
| Uterine fibroids |
| Other gynecologic disorders |
| Other endocrine, nutrition, blood, and immune disorders |
For all subtypes of hemoglobinopathies, genotype is specified in parentheses.
Corresponding International Classification of Diseases, 9th Revision (ICD-9) and ICD-10 diagnoses for each cause category are listed in supplemental Table 3. Distribution of the anemia envelope was completed by finding the proportion of total hemoglobin shift attributable to each condition in each population group. For 10 of 17 underlying etiologies, we multiplied prevalence results from GBD 2010 by cause-specific hemoglobin shifts determined via systematic literature review and/or simulation. Attribution to the other 7 causes was performed via systematic redistribution methods. The conditions included in each of the “other” categories are listed in supplemental Table 3.
Hb, hemoglobin.