Patient demographics and clinical characteristics of patients in cluster 3 and 11
| Characteristics . | Cluster 3 (n = 25) . | AMLs outside cluster 3 (n = 319) . | P1 . | Cluster 11 (n = 19) . | AMLs outside cluster 11 (n = 325) . | P2 . | P3 . |
|---|---|---|---|---|---|---|---|
| Age, years | .00022 | .11 | .17 | ||||
| Median | 58 | 47 | 51 | 48 | |||
| Range | 18-72 | 15-77 | 33-73 | 15-77 | |||
| Missing | 0 | 1 | 0 | 1 | |||
| Sex | .41 | .24 | 1 | ||||
| Male | 16 (64%) | 171 (54%) | 13 (68%) | 174 (54%) | |||
| Female | 9 (36%) | 147 (46%) | 6 (32%) | 150 (46%) | |||
| Missing | 0 | 1 | 0 | 1 | |||
| WBC count (×109/L) | .85 | 1.10E-06 | 7.90E-06 | ||||
| Median | 31 | 34 | 6 | 36 | |||
| Range | 4.8-128 | 0.3-274 | 1.4-33 | 0.3-274 | |||
| Not determined | 0 | 2 | 0 | 2 | |||
| Platelet count (×109/L) | .00054 | .015 | .67 | ||||
| Median | 83 | 57 | 80 | 57 | |||
| Range | 26-931 | 7-742 | 22-374 | 7-931 | |||
| Not determined | 0 | 2 | 0 | 2 | |||
| BM blasts (%) | 7.70E-06 | 3.70E-07 | .45 | ||||
| Median | 34% | 68% | 31% | 68% | |||
| Range | 6-88 | 0-98 | 8-64 | 0-98 | |||
| Not determined | 0 | 12 | 0 | 12 | |||
| Normal karyotype | 11 (44%) | 141 (44.2%) | 1 | 8 (42.1%) | 144 (44.3%) | .82 | .71 |
| RAEB | 4 (16%) | 5 (1.57%) | .0022 | 4 (21.1%) | 5 (1.54%) | .00071 | .72 |
| AML-LBC | 5 (20%) | 5 (1.57%) | .00027 | 5 (26.3%) | 5 (1.54%) | 6.30E-05 | .49 |
| RS | 4 | 10 | .23 | 8 | 6 | .047 | .088 |
| Not determined | 0 | 286 | 0 | 286 | |||
| Erythroblasts (%) | 5% | 3% | .14 | 32% | 3% | 2.60E-09 | 2.00E-05 |
| Range | 1-29 | 0-59 | 8-59 | 0-52 | |||
| Not determined | 2 | 138 | 3 | 137 | |||
| SRSF2 | 9 (36%) | 12 (3.76%) | 1.80E-06 | 2 (10.5%) | 19 (5.85%) | .29 | .085 |
| U2AF35 | 2 (8%) | 5 (1.57%) | .083 | 3 (15.8%) | 4 (1.23%) | .0034 | .63 |
| SF3B1 | 2 (8%) | 5 (1.57%) | .087 | 3 (15.8%) | 4 (1.23%) | .0033 | .38 |
| NRAS/KRAS | 10 (40%) | 30 (9.4%) | 1.40E-05 | 0 (0%) | 40 (12.3%) | .15 | .0023 |
| ASXL1 | 3 (12%) | 16 (5.02%) | .16 | 2 (10.5%) | 17 (5.23%) | .27 | 1 |
| Characteristics . | Cluster 3 (n = 25) . | AMLs outside cluster 3 (n = 319) . | P1 . | Cluster 11 (n = 19) . | AMLs outside cluster 11 (n = 325) . | P2 . | P3 . |
|---|---|---|---|---|---|---|---|
| Age, years | .00022 | .11 | .17 | ||||
| Median | 58 | 47 | 51 | 48 | |||
| Range | 18-72 | 15-77 | 33-73 | 15-77 | |||
| Missing | 0 | 1 | 0 | 1 | |||
| Sex | .41 | .24 | 1 | ||||
| Male | 16 (64%) | 171 (54%) | 13 (68%) | 174 (54%) | |||
| Female | 9 (36%) | 147 (46%) | 6 (32%) | 150 (46%) | |||
| Missing | 0 | 1 | 0 | 1 | |||
| WBC count (×109/L) | .85 | 1.10E-06 | 7.90E-06 | ||||
| Median | 31 | 34 | 6 | 36 | |||
| Range | 4.8-128 | 0.3-274 | 1.4-33 | 0.3-274 | |||
| Not determined | 0 | 2 | 0 | 2 | |||
| Platelet count (×109/L) | .00054 | .015 | .67 | ||||
| Median | 83 | 57 | 80 | 57 | |||
| Range | 26-931 | 7-742 | 22-374 | 7-931 | |||
| Not determined | 0 | 2 | 0 | 2 | |||
| BM blasts (%) | 7.70E-06 | 3.70E-07 | .45 | ||||
| Median | 34% | 68% | 31% | 68% | |||
| Range | 6-88 | 0-98 | 8-64 | 0-98 | |||
| Not determined | 0 | 12 | 0 | 12 | |||
| Normal karyotype | 11 (44%) | 141 (44.2%) | 1 | 8 (42.1%) | 144 (44.3%) | .82 | .71 |
| RAEB | 4 (16%) | 5 (1.57%) | .0022 | 4 (21.1%) | 5 (1.54%) | .00071 | .72 |
| AML-LBC | 5 (20%) | 5 (1.57%) | .00027 | 5 (26.3%) | 5 (1.54%) | 6.30E-05 | .49 |
| RS | 4 | 10 | .23 | 8 | 6 | .047 | .088 |
| Not determined | 0 | 286 | 0 | 286 | |||
| Erythroblasts (%) | 5% | 3% | .14 | 32% | 3% | 2.60E-09 | 2.00E-05 |
| Range | 1-29 | 0-59 | 8-59 | 0-52 | |||
| Not determined | 2 | 138 | 3 | 137 | |||
| SRSF2 | 9 (36%) | 12 (3.76%) | 1.80E-06 | 2 (10.5%) | 19 (5.85%) | .29 | .085 |
| U2AF35 | 2 (8%) | 5 (1.57%) | .083 | 3 (15.8%) | 4 (1.23%) | .0034 | .63 |
| SF3B1 | 2 (8%) | 5 (1.57%) | .087 | 3 (15.8%) | 4 (1.23%) | .0033 | .38 |
| NRAS/KRAS | 10 (40%) | 30 (9.4%) | 1.40E-05 | 0 (0%) | 40 (12.3%) | .15 | .0023 |
| ASXL1 | 3 (12%) | 16 (5.02%) | .16 | 2 (10.5%) | 17 (5.23%) | .27 | 1 |
Number of cases (percentage), median (range) or missing values are depicted were appropriate. P values are computed using Mann-Whitney U test (continues variables) and 2-sided Fisher exact test (categorical variables). Note that percentages are solely based on non-missing values.
P1, the comparison of patients in cluster 3 vs the patients not in cluster 3; P2, the comparison of patients in cluster 11 vs the patients not in cluster 11; P3, the comparison of patients in cluster 3 vs the patients in cluster 11.