Comparison of patient demographics, clinical and molecular characteristics between RAEB with SF mutations, AML-LBC with SF mutations, and AML with SF mutations
| Characteristics . | RAEB with SF mutations (n = 11) . | AML-LBC with SF mutations (n = 11) . | AML with SF mutations (n = 26) . | P . |
|---|---|---|---|---|
| Age, years | .42 | |||
| Median | 68 | 62 | 58 | |
| Range | 45-79 | 37-84 | 37-77 | |
| Missing | 0 | 0 | 0 | |
| Sex | .082 | |||
| Male | 6 (60%) | 9 (75%) | 15 (60%) | |
| Female | 4 (40%) | 3 (25%) | 10 (40%) | |
| Missing | 0 | 0 | 0 | |
| WBC count (×109/L) | .033 | |||
| Median | 3 | 21 | 25 | |
| Range | 1.6-109 | 2-127 | 2.1-76 | |
| ND | 0 | 0 | 0 | |
| Platelet count (×109/L) | .52 | |||
| Median | 86 | 68 | 64 | |
| Range | 35-740 | 15-226 | 10-931 | |
| ND | 0 | 0 | 0 | |
| BM blasts (%) | 4.10E-08 | |||
| Median | 9% | 25% | 51% | |
| Range | 1-19 | 20-29 | 20-93 | |
| ND | 0 | 0 | 3 | |
| Erythroblasts (%) | 22% | 10% | 11% | .38 |
| Range | 2-37 | 1-60 | 1-43 | |
| ND | 0 | 0 | 7 | |
| RS | 2 | 3 | 5 | .084 |
| ND | 0 | 1 | 0 | |
| SRSF2 | 8 (80%) | 7 (58.3%) | 15 (60%) | .042 |
| U2AF35 | 0 (0%) | 4 (33.3%) | 4 (16%) | .02 |
| SF3B1 | 2 (20%) | 1 (8.33%) | 6 (24%) | .07 |
| Characteristics . | RAEB with SF mutations (n = 11) . | AML-LBC with SF mutations (n = 11) . | AML with SF mutations (n = 26) . | P . |
|---|---|---|---|---|
| Age, years | .42 | |||
| Median | 68 | 62 | 58 | |
| Range | 45-79 | 37-84 | 37-77 | |
| Missing | 0 | 0 | 0 | |
| Sex | .082 | |||
| Male | 6 (60%) | 9 (75%) | 15 (60%) | |
| Female | 4 (40%) | 3 (25%) | 10 (40%) | |
| Missing | 0 | 0 | 0 | |
| WBC count (×109/L) | .033 | |||
| Median | 3 | 21 | 25 | |
| Range | 1.6-109 | 2-127 | 2.1-76 | |
| ND | 0 | 0 | 0 | |
| Platelet count (×109/L) | .52 | |||
| Median | 86 | 68 | 64 | |
| Range | 35-740 | 15-226 | 10-931 | |
| ND | 0 | 0 | 0 | |
| BM blasts (%) | 4.10E-08 | |||
| Median | 9% | 25% | 51% | |
| Range | 1-19 | 20-29 | 20-93 | |
| ND | 0 | 0 | 3 | |
| Erythroblasts (%) | 22% | 10% | 11% | .38 |
| Range | 2-37 | 1-60 | 1-43 | |
| ND | 0 | 0 | 7 | |
| RS | 2 | 3 | 5 | .084 |
| ND | 0 | 1 | 0 | |
| SRSF2 | 8 (80%) | 7 (58.3%) | 15 (60%) | .042 |
| U2AF35 | 0 (0%) | 4 (33.3%) | 4 (16%) | .02 |
| SF3B1 | 2 (20%) | 1 (8.33%) | 6 (24%) | .07 |
Number of cases (percentage), median (range), or missing values depicted where appropriate. P values are computed using Kruskal-Wallis test (continues variables) and Fisher exact test (categorical variables).