Multivariate adjusted* HR and 95% CI estimates for death from all causes and from lymphoma for SES quintiles stratified by period of diagnosis, stage at diagnosis, age group at diagnosis, and marital status, California 1988-2009
| . | All-cause mortality . | DLBCL-specific mortality . | ||||
|---|---|---|---|---|---|---|
| No. of deaths . | HR (95% CI) . | Pinteraction . | No. of deaths . | HR (95% CI) . | Pinteraction . | |
| Period of diagnosis | ||||||
| 1988-2000 | .01 | .29 | ||||
| 1. SES lowest 20% | 1875 | 1.31 (1.23-1.40) | 1115 | 1.23 (1.14-1.34) | ||
| 2 | 2420 | 1.24 (1.17-1.31) | 1501 | 1.22 (1.13-1.31) | ||
| 3 | 2746 | 1.19 (1.13-1.26) | 1665 | 1.14 (1.07-1.22) | ||
| 4 | 2887 | 1.10 (1.04-1.16) | 1773 | 1.08 (1.01-1.16) | ||
| 5. SES highest 20% | 2904 | 1.00 (Reference) | 1784 | 1.00 (Reference) | ||
| 2001-2009 | ||||||
| 1. SES lowest 20% | 1204 | 1.37 (1.27-1.49) | 790 | 1.25 (1.14-1.38) | ||
| 2 | 1465 | 1.29 (1.20-1.39) | 1024 | 1.26 (1.15-1.37) | ||
| 3 | 1549 | 1.14 (1.06-1.23) | 1066 | 1.10 (1.01-1.20) | ||
| 4 | 1641 | 1.08 (1.01-1.16) | 1142 | 1.06 (0.97-1.15) | ||
| 5. SES highest 20% | 1628 | 1.00 (Reference) | 1168 | 1.00 (Reference) | ||
| Stage at diagnosis | .11 | .14 | ||||
| Localized/regional stage | ||||||
| 1. SES lowest 20% | 1219 | 1.29 (1.19-1.39) | 663 | 1.19 (1.07-1.31) | ||
| 2 | 1609 | 1.22 (1.14-1.31) | 939 | 1.21 (1.10-1.32) | ||
| 3 | 1816 | 1.15 (1.08-1.22) | 1017 | 1.09 (1.00-1.19) | ||
| 4 | 1941 | 1.10 (1.03-1.17) | 1139 | 1.10 (1.01-1.19) | ||
| 5. SES highest 20% | 2012 | 1.00 (Reference) | 1169 | 1.00 (Reference) | ||
| Advanced stage | ||||||
| 1. SES lowest 20% | 1593 | 1.32 (1.23-1.41) | 1093 | 1.23 (1.13-1.33) | ||
| 2 | 1945 | 1.24 (1.17-1.32) | 1385 | 1.20 (1.11-1.29) | ||
| 3 | 2123 | 1.14 (1.07-1.21) | 1514 | 1.11 (1.03-1.19) | ||
| 4 | 2213 | 1.06 (1.00-1.12) | 1569 | 1.03 (0.96-1.10) | ||
| 5. SES highest 20% | 2246 | 1.00 (Reference) | 1626 | 1.00 (Reference) | ||
| Age at diagnosis, y | <.01 | <.01 | ||||
| 15-64 | ||||||
| 1. SES lowest 20% | 1219 | 1.51 (1.39-1.64) | 811 | 1.49 (1.34-1.65) | ||
| 2 | 1321 | 1.38 (1.27-1.49) | 925 | 1.41 (1.28-1.55) | ||
| 3 | 1379 | 1.22 (1.13-1.32) | 955 | 1.24 (1.13-1.35) | ||
| 4 | 1437 | 1.16 (1.08-1.25) | 982 | 1.16 (1.06-1.27) | ||
| 5. SES highest 20% | 1416 | 1.00 (Reference) | 958 | 1.00 (Reference) | ||
| 65+ | ||||||
| 1. SES lowest 20% | 1860 | 1.26 (1.19-1.34) | 1094 | 1.13 (1.04-1.22) | ||
| 2 | 2564 | 1.21 (1.15-1.28) | 1600 | 1.16 (1.08-1.24) | ||
| 3 | 2916 | 1.16 (1.10-1.22) | 1776 | 1.08 (1.01-1.15) | ||
| 4 | 3091 | 1.06 (1.01-1.12) | 1933 | 1.03 (0.97-1.10) | ||
| 5. SES highest 20% | 3116 | 1.00 (Reference) | 1994 | 1.00 (Reference) | ||
| Marital status at diagnosis | <.01 | <.01 | ||||
| Nonmarried (never married and previously married) | ||||||
| 1. SES lowest 20% | 1557 | 1.28 (1.19-1.38) | 942 | 1.17 (1.06-1.28) | ||
| 2 | 1683 | 1.17 (1.09-1.25) | 1082 | 1.13 (1.04-1.24) | ||
| 3 | 1807 | 1.06 (1.00-1.14) | 1139 | 1.03 (0.94-1.12) | ||
| 4 | 1842 | 1.01 (0.95-1.08) | 1180 | 1.00 (0.92-1.09) | ||
| 5. SES highest 20% | 1654 | 1.00 (Reference) | 1072 | 1.00 (Reference) | ||
| Married | ||||||
| 1. SES lowest 20% | 1436 | 1.34 (1.25-1.44) | 910 | 1.26 (1.16-1.38) | ||
| 2 | 2108 | 1.30 (1.23-1.38) | 1393 | 1.29 (1.20-1.39) | ||
| 3 | 2367 | 1.23 (1.16-1.30) | 1517 | 1.18 (1.10-1.26) | ||
| 4 | 2535 | 1.13 (1.07-1.20) | 1641 | 1.10 (1.03-1.18) | ||
| 5. SES highest 20% | 2776 | 1.00 (Reference) | 1817 | 1.00 (Reference) | ||
| . | All-cause mortality . | DLBCL-specific mortality . | ||||
|---|---|---|---|---|---|---|
| No. of deaths . | HR (95% CI) . | Pinteraction . | No. of deaths . | HR (95% CI) . | Pinteraction . | |
| Period of diagnosis | ||||||
| 1988-2000 | .01 | .29 | ||||
| 1. SES lowest 20% | 1875 | 1.31 (1.23-1.40) | 1115 | 1.23 (1.14-1.34) | ||
| 2 | 2420 | 1.24 (1.17-1.31) | 1501 | 1.22 (1.13-1.31) | ||
| 3 | 2746 | 1.19 (1.13-1.26) | 1665 | 1.14 (1.07-1.22) | ||
| 4 | 2887 | 1.10 (1.04-1.16) | 1773 | 1.08 (1.01-1.16) | ||
| 5. SES highest 20% | 2904 | 1.00 (Reference) | 1784 | 1.00 (Reference) | ||
| 2001-2009 | ||||||
| 1. SES lowest 20% | 1204 | 1.37 (1.27-1.49) | 790 | 1.25 (1.14-1.38) | ||
| 2 | 1465 | 1.29 (1.20-1.39) | 1024 | 1.26 (1.15-1.37) | ||
| 3 | 1549 | 1.14 (1.06-1.23) | 1066 | 1.10 (1.01-1.20) | ||
| 4 | 1641 | 1.08 (1.01-1.16) | 1142 | 1.06 (0.97-1.15) | ||
| 5. SES highest 20% | 1628 | 1.00 (Reference) | 1168 | 1.00 (Reference) | ||
| Stage at diagnosis | .11 | .14 | ||||
| Localized/regional stage | ||||||
| 1. SES lowest 20% | 1219 | 1.29 (1.19-1.39) | 663 | 1.19 (1.07-1.31) | ||
| 2 | 1609 | 1.22 (1.14-1.31) | 939 | 1.21 (1.10-1.32) | ||
| 3 | 1816 | 1.15 (1.08-1.22) | 1017 | 1.09 (1.00-1.19) | ||
| 4 | 1941 | 1.10 (1.03-1.17) | 1139 | 1.10 (1.01-1.19) | ||
| 5. SES highest 20% | 2012 | 1.00 (Reference) | 1169 | 1.00 (Reference) | ||
| Advanced stage | ||||||
| 1. SES lowest 20% | 1593 | 1.32 (1.23-1.41) | 1093 | 1.23 (1.13-1.33) | ||
| 2 | 1945 | 1.24 (1.17-1.32) | 1385 | 1.20 (1.11-1.29) | ||
| 3 | 2123 | 1.14 (1.07-1.21) | 1514 | 1.11 (1.03-1.19) | ||
| 4 | 2213 | 1.06 (1.00-1.12) | 1569 | 1.03 (0.96-1.10) | ||
| 5. SES highest 20% | 2246 | 1.00 (Reference) | 1626 | 1.00 (Reference) | ||
| Age at diagnosis, y | <.01 | <.01 | ||||
| 15-64 | ||||||
| 1. SES lowest 20% | 1219 | 1.51 (1.39-1.64) | 811 | 1.49 (1.34-1.65) | ||
| 2 | 1321 | 1.38 (1.27-1.49) | 925 | 1.41 (1.28-1.55) | ||
| 3 | 1379 | 1.22 (1.13-1.32) | 955 | 1.24 (1.13-1.35) | ||
| 4 | 1437 | 1.16 (1.08-1.25) | 982 | 1.16 (1.06-1.27) | ||
| 5. SES highest 20% | 1416 | 1.00 (Reference) | 958 | 1.00 (Reference) | ||
| 65+ | ||||||
| 1. SES lowest 20% | 1860 | 1.26 (1.19-1.34) | 1094 | 1.13 (1.04-1.22) | ||
| 2 | 2564 | 1.21 (1.15-1.28) | 1600 | 1.16 (1.08-1.24) | ||
| 3 | 2916 | 1.16 (1.10-1.22) | 1776 | 1.08 (1.01-1.15) | ||
| 4 | 3091 | 1.06 (1.01-1.12) | 1933 | 1.03 (0.97-1.10) | ||
| 5. SES highest 20% | 3116 | 1.00 (Reference) | 1994 | 1.00 (Reference) | ||
| Marital status at diagnosis | <.01 | <.01 | ||||
| Nonmarried (never married and previously married) | ||||||
| 1. SES lowest 20% | 1557 | 1.28 (1.19-1.38) | 942 | 1.17 (1.06-1.28) | ||
| 2 | 1683 | 1.17 (1.09-1.25) | 1082 | 1.13 (1.04-1.24) | ||
| 3 | 1807 | 1.06 (1.00-1.14) | 1139 | 1.03 (0.94-1.12) | ||
| 4 | 1842 | 1.01 (0.95-1.08) | 1180 | 1.00 (0.92-1.09) | ||
| 5. SES highest 20% | 1654 | 1.00 (Reference) | 1072 | 1.00 (Reference) | ||
| Married | ||||||
| 1. SES lowest 20% | 1436 | 1.34 (1.25-1.44) | 910 | 1.26 (1.16-1.38) | ||
| 2 | 2108 | 1.30 (1.23-1.38) | 1393 | 1.29 (1.20-1.39) | ||
| 3 | 2367 | 1.23 (1.16-1.30) | 1517 | 1.18 (1.10-1.26) | ||
| 4 | 2535 | 1.13 (1.07-1.20) | 1641 | 1.10 (1.03-1.18) | ||
| 5. SES highest 20% | 2776 | 1.00 (Reference) | 1817 | 1.00 (Reference) | ||
All Cox models were adjusted for age at diagnosis (continuous), sex, race/ethnicity, presence of B symptoms, nodal status, urbanicity, NCI-designated hospital, and first course (chemotherapy and radiation therapy) of treatment; stage at diagnosis (localized, regional, advanced, and unknown) was included as a stratifying variable for analyses by period of diagnosis and age group at diagnosis.