Table 6

Predictors of pregnancy outcomes in APS women

Outcome, modelsVariablesOR (95%CI)P
Abortion (embryonic loss)    
 Univariate aβ2GP1-M 0.52 (0.32-0.86) .013 
  Hypertriglyceridemia 0.37 (0.08-1.59) .18 
  Varicose veins 0.69 (0.39-1.24) .21 
 Multivariate* aβ2GP1-M 0.55 (0.30-0.89) .021 
Fetal loss    
 Univariate Prior fetal loss 2.10 (1.16-3.79) .015 
  Familial atherothrombosis 1.75 (0.82-3.75) .15 
  Familial venous thromboembolism 2.78 (0.68-11.4) .17 
  Primary loss 0.72 (0.42-1.23) .22 
 Multivariate* Prior fetal loss 2.08 (1.13-3.83) .019 
PE    
 Univariate Prior fetal loss 2.73 (1.40-5.34) .003 
  BMI >30 kg/m2 2.22 (1.08-4.54) .030 
  Varicose veins 0.48 (0.22-1.05) .07 
  Tobacco smoking 1.94 (0.87-4.31) .10 
  aCL-M 1.70 (0.85-3.41) .13 
  LA 1.55 (0.85-2.83) .16 
 Multivariate* Prior fetal loss 2.68 (1.35-5.32) .005 
 BMI >30 kg/m2 2.23 (1.05-4.73) .037 
 Varicose veins 0.50 (0.20-1.10) .09 
Early-onset PE    
Univariate BMI >30 kg/m2 2.10 (0.91-4.88) .08 
 Prior fetal loss 1.91 (0.90-4.05) .09 
 Varicose veins 0.46 (0.17-1.21) .11 
 aCL-M 1.77 (0.76-4.14) .19 
 Tobacco smoking 1.86 (0.73-4.75) .20 
Multivariate* Prior fetal loss 1.99 (0.93-4.26) .08 
 Varicose veins 0.42 (0.16-1.13) .09 
Premature birth before 37 WG    
 Univariate Prior fetal loss 3.03 (1.76-5.22) <.0001 
  aCL-M 1.63 (0.91-2.91) .10 
  Hypertriglyceridemia 2.10 (0.83-5.31) .12 
  aCL-G 1.41 (0.87-2.29) .16 
  Familial atherothrombosis 0.51 (0.19-1.36) .18 
  Age >35 y 0.26 (0.03-2.08) .21 
 Multivariate* Prior fetal loss 2.95 (1.69-5.15) .0001 
 aCL-G 1.58 (0.95-2.64) .08 
 Hypertriglyceridemia 2.39 (0.88-6.50) .09 
Premature birth before 34 WG    
 Univariate Prior fetal loss 3.21 (1.49-6.90) .003 
  Varicose veins 0.56 (0.24-1.30) .18 
  Tobacco smoking 1.85 (0.76-4.51) .18 
  aβ2GP1-G 1.59 (0.79-3.22) .19 
  Hypertension 2.21 (0.58-8.36) .24 
 Multivariate* Prior fetal loss 3.24 (1.47-7.13) .004 
 Tobacco smoking 2.18 (0.86-5.52) .10 
 Varicose veins 0.48 (0.20-1.16) .10 
SGA neonate    
 Univariate aCL-M 2.02 (1.06-3.85) .033 
  Varicose veins 0.55 (0.28-1.08) .08 
  LA 1.60 (0.92-2.76) .10 
  aβ2GP1-M 1.43 (0.86-2.39) .17 
  Primary loss 1.47 (0.83-2.58) .19 
 Multivariate* LA 1.67 (0.97-2.89) .07 
Any placenta-mediated complications    
 Univariate Prior fetal loss 1.77 (1.07-2.90) .025 
  aCL-M 1.82 (1.03-3.23) .040 
  Varicose veins 0.53 (0.29-0.98) .041 
  BMI >30 kg/m2 1.56 (0.79-3.08) .21 
  LA 1.33 (0.81-2.18) .25 
 Multivariate* aCL-M 2.02 (1.09.3.73) .025 
 Varicose veins 0.50 (0.27-0.93) .028 
 Prior fetal loss 1.67 (1.01-2.80) .049 
 LA 1.54 (0.91-2.61) .11 
Outcome, modelsVariablesOR (95%CI)P
Abortion (embryonic loss)    
 Univariate aβ2GP1-M 0.52 (0.32-0.86) .013 
  Hypertriglyceridemia 0.37 (0.08-1.59) .18 
  Varicose veins 0.69 (0.39-1.24) .21 
 Multivariate* aβ2GP1-M 0.55 (0.30-0.89) .021 
Fetal loss    
 Univariate Prior fetal loss 2.10 (1.16-3.79) .015 
  Familial atherothrombosis 1.75 (0.82-3.75) .15 
  Familial venous thromboembolism 2.78 (0.68-11.4) .17 
  Primary loss 0.72 (0.42-1.23) .22 
 Multivariate* Prior fetal loss 2.08 (1.13-3.83) .019 
PE    
 Univariate Prior fetal loss 2.73 (1.40-5.34) .003 
  BMI >30 kg/m2 2.22 (1.08-4.54) .030 
  Varicose veins 0.48 (0.22-1.05) .07 
  Tobacco smoking 1.94 (0.87-4.31) .10 
  aCL-M 1.70 (0.85-3.41) .13 
  LA 1.55 (0.85-2.83) .16 
 Multivariate* Prior fetal loss 2.68 (1.35-5.32) .005 
 BMI >30 kg/m2 2.23 (1.05-4.73) .037 
 Varicose veins 0.50 (0.20-1.10) .09 
Early-onset PE    
Univariate BMI >30 kg/m2 2.10 (0.91-4.88) .08 
 Prior fetal loss 1.91 (0.90-4.05) .09 
 Varicose veins 0.46 (0.17-1.21) .11 
 aCL-M 1.77 (0.76-4.14) .19 
 Tobacco smoking 1.86 (0.73-4.75) .20 
Multivariate* Prior fetal loss 1.99 (0.93-4.26) .08 
 Varicose veins 0.42 (0.16-1.13) .09 
Premature birth before 37 WG    
 Univariate Prior fetal loss 3.03 (1.76-5.22) <.0001 
  aCL-M 1.63 (0.91-2.91) .10 
  Hypertriglyceridemia 2.10 (0.83-5.31) .12 
  aCL-G 1.41 (0.87-2.29) .16 
  Familial atherothrombosis 0.51 (0.19-1.36) .18 
  Age >35 y 0.26 (0.03-2.08) .21 
 Multivariate* Prior fetal loss 2.95 (1.69-5.15) .0001 
 aCL-G 1.58 (0.95-2.64) .08 
 Hypertriglyceridemia 2.39 (0.88-6.50) .09 
Premature birth before 34 WG    
 Univariate Prior fetal loss 3.21 (1.49-6.90) .003 
  Varicose veins 0.56 (0.24-1.30) .18 
  Tobacco smoking 1.85 (0.76-4.51) .18 
  aβ2GP1-G 1.59 (0.79-3.22) .19 
  Hypertension 2.21 (0.58-8.36) .24 
 Multivariate* Prior fetal loss 3.24 (1.47-7.13) .004 
 Tobacco smoking 2.18 (0.86-5.52) .10 
 Varicose veins 0.48 (0.20-1.16) .10 
SGA neonate    
 Univariate aCL-M 2.02 (1.06-3.85) .033 
  Varicose veins 0.55 (0.28-1.08) .08 
  LA 1.60 (0.92-2.76) .10 
  aβ2GP1-M 1.43 (0.86-2.39) .17 
  Primary loss 1.47 (0.83-2.58) .19 
 Multivariate* LA 1.67 (0.97-2.89) .07 
Any placenta-mediated complications    
 Univariate Prior fetal loss 1.77 (1.07-2.90) .025 
  aCL-M 1.82 (1.03-3.23) .040 
  Varicose veins 0.53 (0.29-0.98) .041 
  BMI >30 kg/m2 1.56 (0.79-3.08) .21 
  LA 1.33 (0.81-2.18) .25 
 Multivariate* aCL-M 2.02 (1.09.3.73) .025 
 Varicose veins 0.50 (0.27-0.93) .028 
 Prior fetal loss 1.67 (1.01-2.80) .049 
 LA 1.54 (0.91-2.61) .11 

Results are restricted to putative predictors with P value < .25 in the univariate analysis and to those with a P value < .10 in the multivariate analysis, adjusted for predictors with P < .25 in the univariate analysis.

aβ2GP1-G, positive for anti-β2-glycoprotein I IgG; aβ2GP1-M, positive anti-β2-glycoprotein I IgM; aCL-G, positive for anticardiolipin IgG; aCL-M, positive for anticardiolipin IgM; LA, positive for lupus anticoagulant.

*

Adjusted for the individual variables identified as significant by univariate analysis.

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