Outcomes of new pregnancies in APS women and in control women with prior recurrent abortions
| . | APS, 206 . | Control, 483 . | . | . | ||
|---|---|---|---|---|---|---|
| Group, N . | N . | Incidence . | N . | Incidence . | RR, 95% CI . | P . |
| New pregnancies | 205 | 0.995 | 480 | 0.994 | ||
| Spontaneous abortions before 10 WG | 38 | 0.185 | 92 | 0.192 | 0.968 (0.689-1.362) | .854 |
| Ongoing pregnancies at 10 WG | 167 | 0.815 | 391 | 0.815 | 1,007 (0,932-1,089) | .853 |
| Fetal losses (% of new pregnancies) | 17 | 0.083 | 9 | 0.019 | 4.429 (2.007-9.772) | .0002 |
| Fetal losses (% of ongoing pregnancies at 10 WG) | 17 | 0.102 | 9 | 0.023 | 4.396 (2.000-9.662) | .0002 |
| Ongoing pregnancy at 20 WG (% of new pregnancies) | 161 | 0.785 | 387 | 0.806 | 0.975 (0.896-1.062) | .565 |
| Live births (% of new pregnancies) | 151 | 0.737 | 382 | 0.796 | 0.959 (0.869-1.057) | .398 |
| Live births (% of ongoing pregnancies at 10 WG) | 151 | 0.904 | 382 | 0.977 | 0.920 (0.873-0.970) | .0020 |
| Preterm live births <37 WG (% of live births) | 21 | 0.139 | 35 | 0.092 | 1.518 (0.914-2.521) | .107 |
| Preterm live births <34 WG (% of live births) | 9 | 0.060 | 13 | 0.034 | 1.751 (0.765-4.012) | .185 |
| PE (% of ongoing pregnancies at 20 WG) | 12 | 0.075 | 11 | 0.028 | 2.622 (1.182-5.820) | .0178 |
| Severe PE | 8 | 0.050 | 6 | 0.016 | 3.205 (1.130-9.090) | .0285 |
| PE <34 WG | 10 | 0.062 | 4 | 0.010 | 6.009 (1.913-18.88) | .0021 |
| Eclampsia | 2 | 0.012 | 3 | 0.008 | 1.603 (0.270-9.500) | .604 |
| HELLP syndrome | 3 | 0.018 | 2 | 0.005 | 3.606 (0.608-21.34) | .158 |
| SGA (% of ongoing pregnancies at 20 WG) | 27 | 0.168 | 43 | 0.111 | 1.509 (0.967-2.355) | .070 |
| Severe SGA <p5 | 13 | 0.081 | 21 | 0.054 | 1.488 (0.764-2.899) | .243 |
| Very severe SGA <p3 | 9 | 0.056 | 13 | 0.034 | 1.664 (0.726-3.816) | .229 |
| PE + SGA | 9 | 0.056 | 7 | 0.018 | 3.091 (1.171-8.157) | .0227 |
| PA (% of ongoing pregnancies at 20 WG) | 4 | 0.025 | 5 | 0.013 | 1.923 (0.523-7.069) | .325 |
| Placenta-mediated complications: PE and/or SGA and/or PA (% of ongoing pregnancies at 20 WG) | 33 | 0.205 | 49 | 0.127 | 1.619 (1.084-2.418) | .0186 |
| NM (% of live births) | 6 | 0.040 | 4 | 0.010 | 3.795 (1.086-13.259) | .0367 |
| Early NM, day 1-7 | 4 | 0.027 | 2 | 0.005 | 5.060 (0.937-27.336) | .0596 |
| Late NM, day 8-27 | 2 | 0.013 | 2 | 0.005 | 2.530 (0.360-17.798) | .351 |
| . | APS, 206 . | Control, 483 . | . | . | ||
|---|---|---|---|---|---|---|
| Group, N . | N . | Incidence . | N . | Incidence . | RR, 95% CI . | P . |
| New pregnancies | 205 | 0.995 | 480 | 0.994 | ||
| Spontaneous abortions before 10 WG | 38 | 0.185 | 92 | 0.192 | 0.968 (0.689-1.362) | .854 |
| Ongoing pregnancies at 10 WG | 167 | 0.815 | 391 | 0.815 | 1,007 (0,932-1,089) | .853 |
| Fetal losses (% of new pregnancies) | 17 | 0.083 | 9 | 0.019 | 4.429 (2.007-9.772) | .0002 |
| Fetal losses (% of ongoing pregnancies at 10 WG) | 17 | 0.102 | 9 | 0.023 | 4.396 (2.000-9.662) | .0002 |
| Ongoing pregnancy at 20 WG (% of new pregnancies) | 161 | 0.785 | 387 | 0.806 | 0.975 (0.896-1.062) | .565 |
| Live births (% of new pregnancies) | 151 | 0.737 | 382 | 0.796 | 0.959 (0.869-1.057) | .398 |
| Live births (% of ongoing pregnancies at 10 WG) | 151 | 0.904 | 382 | 0.977 | 0.920 (0.873-0.970) | .0020 |
| Preterm live births <37 WG (% of live births) | 21 | 0.139 | 35 | 0.092 | 1.518 (0.914-2.521) | .107 |
| Preterm live births <34 WG (% of live births) | 9 | 0.060 | 13 | 0.034 | 1.751 (0.765-4.012) | .185 |
| PE (% of ongoing pregnancies at 20 WG) | 12 | 0.075 | 11 | 0.028 | 2.622 (1.182-5.820) | .0178 |
| Severe PE | 8 | 0.050 | 6 | 0.016 | 3.205 (1.130-9.090) | .0285 |
| PE <34 WG | 10 | 0.062 | 4 | 0.010 | 6.009 (1.913-18.88) | .0021 |
| Eclampsia | 2 | 0.012 | 3 | 0.008 | 1.603 (0.270-9.500) | .604 |
| HELLP syndrome | 3 | 0.018 | 2 | 0.005 | 3.606 (0.608-21.34) | .158 |
| SGA (% of ongoing pregnancies at 20 WG) | 27 | 0.168 | 43 | 0.111 | 1.509 (0.967-2.355) | .070 |
| Severe SGA <p5 | 13 | 0.081 | 21 | 0.054 | 1.488 (0.764-2.899) | .243 |
| Very severe SGA <p3 | 9 | 0.056 | 13 | 0.034 | 1.664 (0.726-3.816) | .229 |
| PE + SGA | 9 | 0.056 | 7 | 0.018 | 3.091 (1.171-8.157) | .0227 |
| PA (% of ongoing pregnancies at 20 WG) | 4 | 0.025 | 5 | 0.013 | 1.923 (0.523-7.069) | .325 |
| Placenta-mediated complications: PE and/or SGA and/or PA (% of ongoing pregnancies at 20 WG) | 33 | 0.205 | 49 | 0.127 | 1.619 (1.084-2.418) | .0186 |
| NM (% of live births) | 6 | 0.040 | 4 | 0.010 | 3.795 (1.086-13.259) | .0367 |
| Early NM, day 1-7 | 4 | 0.027 | 2 | 0.005 | 5.060 (0.937-27.336) | .0596 |
| Late NM, day 8-27 | 2 | 0.013 | 2 | 0.005 | 2.530 (0.360-17.798) | .351 |
95% CI, 95% confidence interval; NM, neonatal mortality; PA, placental abruption; RR, relative risk, APS women vs control women.