Multivariable analyses of mutations, treatments, and their interactions for survival after FC and FCR treatment
| Parameter . | HR . | 95% CI . | P value . |
|---|---|---|---|
| PFS | |||
| FCR | 0.544 | 0.445-0.665 | <.001 |
| TP53mut | 3.607 | 2.737-4.755 | <.001 |
| SF3B1mut | 1.355 | 1.070-1.717 | .012 |
| NOTCH1mut interaction | 1.652 | 1.076-2.535 | .022 |
| OS | |||
| FCR | 0.654 | 0.498-0.860 | .002 |
| TP53mut | 4.470 | 3.234-6.177 | <.001 |
| Parameter . | HR . | 95% CI . | P value . |
|---|---|---|---|
| PFS | |||
| FCR | 0.544 | 0.445-0.665 | <.001 |
| TP53mut | 3.607 | 2.737-4.755 | <.001 |
| SF3B1mut | 1.355 | 1.070-1.717 | .012 |
| NOTCH1mut interaction | 1.652 | 1.076-2.535 | .022 |
| OS | |||
| FCR | 0.654 | 0.498-0.860 | .002 |
| TP53mut | 4.470 | 3.234-6.177 | <.001 |
Variables included in the models: FC, FCR, TP53mut, NOTCH1mut, SF3B1mut, and the interactions of each gene mutation with treatments.