Multivariable analyses of prognostic factors for survival
| Parameter . | HR . | 95% CI . | P value . |
|---|---|---|---|
| PFS | |||
| FCR | 0.506 | 0.408-0.628 | <.001 |
| TK ≥10 U/L | 1.362 | 1.049-1.769 | .020 |
| IGHV-U | 1.719 | 1.326-2.228 | <.001 |
| 11q− | 1.546 | 1.215-1.968 | <.001 |
| 17p− | 2.916 | 1.779-4.781 | <.001 |
| TP53mut | 2.123 | 1.400-3.218 | <.001 |
| SF3B1mut | 1.346 | 1.037-1.747 | .026 |
| OS | |||
| FCR | 0.650 | 0.480-0.880 | .005 |
| Age ≥65 y | 1.423 | 1.039-1.950 | .028 |
| ECOG ≥1 | 1.622 | 1.190-2.209 | .002 |
| β2-MG ≥3.5 mg/L | 1.473 | 1.069-2.030 | .018 |
| TK ≥10 U/L | 1.864 | 1.195-2.909 | .006 |
| IGHV-U | 2.059 | 1.389-3.053 | <.001 |
| 17p− | 2.715 | 1.602-4.602 | <.001 |
| TP53mut | 3.014 | 1.889-4.808 | <.001 |
| Parameter . | HR . | 95% CI . | P value . |
|---|---|---|---|
| PFS | |||
| FCR | 0.506 | 0.408-0.628 | <.001 |
| TK ≥10 U/L | 1.362 | 1.049-1.769 | .020 |
| IGHV-U | 1.719 | 1.326-2.228 | <.001 |
| 11q− | 1.546 | 1.215-1.968 | <.001 |
| 17p− | 2.916 | 1.779-4.781 | <.001 |
| TP53mut | 2.123 | 1.400-3.218 | <.001 |
| SF3B1mut | 1.346 | 1.037-1.747 | .026 |
| OS | |||
| FCR | 0.650 | 0.480-0.880 | .005 |
| Age ≥65 y | 1.423 | 1.039-1.950 | .028 |
| ECOG ≥1 | 1.622 | 1.190-2.209 | .002 |
| β2-MG ≥3.5 mg/L | 1.473 | 1.069-2.030 | .018 |
| TK ≥10 U/L | 1.864 | 1.195-2.909 | .006 |
| IGHV-U | 2.059 | 1.389-3.053 | <.001 |
| 17p− | 2.715 | 1.602-4.602 | <.001 |
| TP53mut | 3.014 | 1.889-4.808 | <.001 |
Variables included in the models: FC, FCR, age, sex, stage, ECOG performance status, CIRS score, B symptoms, white blood cell count, TK, β2-MG, 11q−, +12, 13q−, 17p−, IGHV mutational status, TP53mut, NOTCH1mut, SF3B1mut.
CI, confidence interval; U, unmutated.