Table 2 Multivariable analyses of... | American Society of Hematology

Table 2

Multivariable analyses of prognostic factors for survival

Parameter	HR	95% CI	P value
PFS
FCR	0.506	0.408-0.628	<.001
TK ≥10 U/L	1.362	1.049-1.769	.020
IGHV-U	1.719	1.326-2.228	<.001
11q−	1.546	1.215-1.968	<.001
17p−	2.916	1.779-4.781	<.001
TP53^mut	2.123	1.400-3.218	<.001
SF3B1^mut	1.346	1.037-1.747	.026
OS
FCR	0.650	0.480-0.880	.005
Age ≥65 y	1.423	1.039-1.950	.028
ECOG ≥1	1.622	1.190-2.209	.002
β2-MG ≥3.5 mg/L	1.473	1.069-2.030	.018
TK ≥10 U/L	1.864	1.195-2.909	.006
IGHV-U	2.059	1.389-3.053	<.001
17p−	2.715	1.602-4.602	<.001
TP53^mut	3.014	1.889-4.808	<.001

Parameter	HR	95% CI	P value
PFS
FCR	0.506	0.408-0.628	<.001
TK ≥10 U/L	1.362	1.049-1.769	.020
IGHV-U	1.719	1.326-2.228	<.001
11q−	1.546	1.215-1.968	<.001
17p−	2.916	1.779-4.781	<.001
TP53^mut	2.123	1.400-3.218	<.001
SF3B1^mut	1.346	1.037-1.747	.026
OS
FCR	0.650	0.480-0.880	.005
Age ≥65 y	1.423	1.039-1.950	.028
ECOG ≥1	1.622	1.190-2.209	.002
β2-MG ≥3.5 mg/L	1.473	1.069-2.030	.018
TK ≥10 U/L	1.864	1.195-2.909	.006
IGHV-U	2.059	1.389-3.053	<.001
17p−	2.715	1.602-4.602	<.001
TP53^mut	3.014	1.889-4.808	<.001

Variables included in the models: FC, FCR, age, sex, stage, ECOG performance status, CIRS score, B symptoms, white blood cell count, TK, β2-MG, 11q−, +12, 13q−, 17p−, IGHV mutational status, TP53^mut, NOTCH1^mut, SF3B1^mut.

CI, confidence interval; U, unmutated.

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