Table 1 Outcome in patient subgroups... | American Society of Hematology

Table 1

Outcome in patient subgroups defined by mutations (columns) and treatment (rows)

	TP53^wt (n = 556)	TP53^mut (n = 72)	P value*	NOTCH1^wt (n = 560)	NOTCH1^mut (n = 62)	P value*	SF3B1^wt (n = 507)	SF3B1^mut (n = 114)	P value*
Clinical response (% CR + PR)
FC	92.2	51.6	<.001	88.1	87.1	.775	87.7	89.1	1.000
FCR	98.2	75.0	<.001	96.6	90.0	.109	96.3	96.4	1.000
P value†	.002	.105		<.001	1.000		<.001	.287
MRD negativity (% <10⁻⁴)
FC	37.3	7.7	.034	32.5	50.0	.338	37.5	23.5	.151
FCR	68.0	18.2	.002	66.1	46.2	.222	64.1	66.7	.832
P value†	<.001	.576		<.001	1.000		<.001	<.001
PFS (median in mo)
FC	35.9	12.1	<.001	32.8	33.9	.743	33.9	28.6	.008
FCR	59.0	15.4	<.001	57.3	34.2	.013	59.1	42.9	.033
P value†	<.001	.001		<.001	.996		<.001	.004
OS (median in mo)
FC	89.6	30.4	<.001	83.7	85.9	.597	86.4	75.6	.172
FCR	NR	42.2	<.001	NR	79.2	.112	NR	NR	.301
P value†	.014	.166		<.001	.793		.004	.100

	TP53^wt (n = 556)	TP53^mut (n = 72)	P value*	NOTCH1^wt (n = 560)	NOTCH1^mut (n = 62)	P value*	SF3B1^wt (n = 507)	SF3B1^mut (n = 114)	P value*
Clinical response (% CR + PR)
FC	92.2	51.6	<.001	88.1	87.1	.775	87.7	89.1	1.000
FCR	98.2	75.0	<.001	96.6	90.0	.109	96.3	96.4	1.000
P value†	.002	.105		<.001	1.000		<.001	.287
MRD negativity (% <10⁻⁴)
FC	37.3	7.7	.034	32.5	50.0	.338	37.5	23.5	.151
FCR	68.0	18.2	.002	66.1	46.2	.222	64.1	66.7	.832
P value†	<.001	.576		<.001	1.000		<.001	<.001
PFS (median in mo)
FC	35.9	12.1	<.001	32.8	33.9	.743	33.9	28.6	.008
FCR	59.0	15.4	<.001	57.3	34.2	.013	59.1	42.9	.033
P value†	<.001	.001		<.001	.996		<.001	.004
OS (median in mo)
FC	89.6	30.4	<.001	83.7	85.9	.597	86.4	75.6	.172
FCR	NR	42.2	<.001	NR	79.2	.112	NR	NR	.301
P value†	.014	.166		<.001	.793		.004	.100

CR, complete response; mut, mutated; NR, not reached; PR, partial response; wt, wild-type.

P value columns compare outcome between subgroups defined by mutation status within 1 treatment arm.

P value rows compare outcome between treatment arms within subgroups defined by mutation status.