Proposed diagnostic workup for unexplained or refractory IDA
| . | H pylori . | Autoimmune gastritis . | Celiac disease . | IRIDA . |
|---|---|---|---|---|
| Screening | H pylori IgG antibodies or fecal antigen | Serum gastrin anti-parietal Abs anti-intrinsic factor Abs | TTG IgA Abs | Suggestive history and clinical assessment |
| Advanced | Urease breath test gastroscopy and biopsies (optional) | Gastroscopy and biopsies (recommended) | Duodenal biopsy, HLA screening for DQ2 or DQ8 genotypes | Sequencing of the TMPRSS6 gene |
| Response to specific treatment | H pylori eradication | NA | Gluten-free diet | NA |
| . | H pylori . | Autoimmune gastritis . | Celiac disease . | IRIDA . |
|---|---|---|---|---|
| Screening | H pylori IgG antibodies or fecal antigen | Serum gastrin anti-parietal Abs anti-intrinsic factor Abs | TTG IgA Abs | Suggestive history and clinical assessment |
| Advanced | Urease breath test gastroscopy and biopsies (optional) | Gastroscopy and biopsies (recommended) | Duodenal biopsy, HLA screening for DQ2 or DQ8 genotypes | Sequencing of the TMPRSS6 gene |
| Response to specific treatment | H pylori eradication | NA | Gluten-free diet | NA |
NA, not applicable.