Table 1

List of top 50 genes up-regulated by IL-4 in resident macrophages

Gene symbolDescriptionFold change
AA467197 Expressed sequence AA467197 665.9877 
Chi3l4 Chitinase-like 4 or Ym2 526.5159 
Aqp3 Aquaporin 3 295.7499 
Sprr2a2 Small proline-rich protein 2A2 149.7646 
Cst7 Cystatin F (leukocystatin) 135.3837 
Havcr1 Hepatitis A virus cellular receptor 1 116.3776 
Mall Mal, T cell differentiation protein-like 109.5096 
Ddx4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 107.4824 
Tmigd1 Transmembrane and immunoglobulin domain containing 1 92.0161 
Timd2 T-cell immunoglobulin and mucin domain containing 2 90.5118 
Chi3l3 Chitinase-like 3 or Ym1 81.1482 
Ucp1 Uncoupling protein 1 (mitochondrial, proton carrier) 74.1526 
Serpinb7 Serine (or cysteine) peptidase inhibitor, clade B, member 7 72.4033 
Tcf23 Transcription factor 23 70.0783 
Ear10 Eosinophil-associated, ribonuclease A family, member 10 66.9156 
Ear11 Eosinophil-associated, ribonuclease A family, member 11 63.0005 
Gm4610 Predicted gene 4610 53.6569 
Syt10 Synaptotagmin X 52.9130 
Gm5150 Predicted gene 5150 49.2676 
Klk1b11 Kallikrein 1-related peptidase b11 47.2572 
Car12 Carbonic anyhydrase 12 43.5869 
Gatm Glycine amidinotransferase (l-arginine:glycine amidinotransferase) 42.6830 
I830127L07Rik RIKEN cDNA I830127L07 gene 38.1699 
LOC101056540 Unknown 35.2395 
Asns Asparagine synthetase 33.8962 
Rrm2 Ribonucleotide reductase M2 32.8288 
Chchd10 Coiled-coil-helix-coiled-coil-helix domain containing 10 31.9263 
Flt1 FMS-like tyrosine kinase 1 31.6849 
Slc7a2 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 30.7286 
Galnt6 UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 30.3134 
Trib3 Tribbles homolog 3 (Drosophila) 27.4894 
A530064D06Rik RIKEN cDNA A530064D06 gene 26.7710 
Ccrn4l CCR4 carbon catabolite repression 4-like (S cerevisiae) 25.7457 
Grhl3 Grainyhead-like 3 (Drosophila) 25.1532 
Entpd3 Ectonucleoside triphosphate diphosphohydrolase 3 24.6177 
Kcnn4 Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 22.9964 
Fxyd6 FXYD domain-containing ion transport regulator 6 22.4216 
Hist1h1b Histone cluster 1, H1b 22.4066 
Arg1 Arginase, liver 22.1165 
Oasl1 2'-5′ oligoadenylate synthetase-like 1 21.4259 
Gfra2 Glial cell line derived neurotrophic factor family receptor α 2 20.4561 
Anpep Alanyl (membrane) aminopeptidase 20.3326 
Shcbp1 Shc SH2-domain binding protein 1 19.8717 
Sema3b Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 19.7311 
Pbk PDZ binding kinase 19.4258 
Spp1 Secreted phosphoprotein 1 19.0967 
Ccna2 Cyclin A2 18.2413 
Nuf2 NUF2, NDC80 kinetochore complex component, homolog (S cerevisiae) 18.0971 
Ccnf Cyclin F 17.6265 
Plxna2 Plexin A2 17.4434 
Gene symbolDescriptionFold change
AA467197 Expressed sequence AA467197 665.9877 
Chi3l4 Chitinase-like 4 or Ym2 526.5159 
Aqp3 Aquaporin 3 295.7499 
Sprr2a2 Small proline-rich protein 2A2 149.7646 
Cst7 Cystatin F (leukocystatin) 135.3837 
Havcr1 Hepatitis A virus cellular receptor 1 116.3776 
Mall Mal, T cell differentiation protein-like 109.5096 
Ddx4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 107.4824 
Tmigd1 Transmembrane and immunoglobulin domain containing 1 92.0161 
Timd2 T-cell immunoglobulin and mucin domain containing 2 90.5118 
Chi3l3 Chitinase-like 3 or Ym1 81.1482 
Ucp1 Uncoupling protein 1 (mitochondrial, proton carrier) 74.1526 
Serpinb7 Serine (or cysteine) peptidase inhibitor, clade B, member 7 72.4033 
Tcf23 Transcription factor 23 70.0783 
Ear10 Eosinophil-associated, ribonuclease A family, member 10 66.9156 
Ear11 Eosinophil-associated, ribonuclease A family, member 11 63.0005 
Gm4610 Predicted gene 4610 53.6569 
Syt10 Synaptotagmin X 52.9130 
Gm5150 Predicted gene 5150 49.2676 
Klk1b11 Kallikrein 1-related peptidase b11 47.2572 
Car12 Carbonic anyhydrase 12 43.5869 
Gatm Glycine amidinotransferase (l-arginine:glycine amidinotransferase) 42.6830 
I830127L07Rik RIKEN cDNA I830127L07 gene 38.1699 
LOC101056540 Unknown 35.2395 
Asns Asparagine synthetase 33.8962 
Rrm2 Ribonucleotide reductase M2 32.8288 
Chchd10 Coiled-coil-helix-coiled-coil-helix domain containing 10 31.9263 
Flt1 FMS-like tyrosine kinase 1 31.6849 
Slc7a2 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 30.7286 
Galnt6 UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 30.3134 
Trib3 Tribbles homolog 3 (Drosophila) 27.4894 
A530064D06Rik RIKEN cDNA A530064D06 gene 26.7710 
Ccrn4l CCR4 carbon catabolite repression 4-like (S cerevisiae) 25.7457 
Grhl3 Grainyhead-like 3 (Drosophila) 25.1532 
Entpd3 Ectonucleoside triphosphate diphosphohydrolase 3 24.6177 
Kcnn4 Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 22.9964 
Fxyd6 FXYD domain-containing ion transport regulator 6 22.4216 
Hist1h1b Histone cluster 1, H1b 22.4066 
Arg1 Arginase, liver 22.1165 
Oasl1 2'-5′ oligoadenylate synthetase-like 1 21.4259 
Gfra2 Glial cell line derived neurotrophic factor family receptor α 2 20.4561 
Anpep Alanyl (membrane) aminopeptidase 20.3326 
Shcbp1 Shc SH2-domain binding protein 1 19.8717 
Sema3b Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 19.7311 
Pbk PDZ binding kinase 19.4258 
Spp1 Secreted phosphoprotein 1 19.0967 
Ccna2 Cyclin A2 18.2413 
Nuf2 NUF2, NDC80 kinetochore complex component, homolog (S cerevisiae) 18.0971 
Ccnf Cyclin F 17.6265 
Plxna2 Plexin A2 17.4434 
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