Table 4 Incidence of severe adverse... | American Society of Hematology

Table 4

Incidence of severe adverse events (≥grade 3) per treatment arm

Treatment arm	FC (139)				FCA (133)
Grade	All	3	4	5	All	3	4	5	P
Infections, all:	70	63	2	5	81	67	8	6	NS
Neutropenic	28	24	2	2	26	25	1	0	NS
Non-neutropenic	31	31	0	0	27	21	3	3	NS
Opportunistic	11	8	0	3	28	21	4	3	.002
Organ-related	13	10	2	1	36	33	1	2	.0005
Flulike syndrome	3	3	0	0	27	27	0	0	<.0001
Allergy	3	3	0	0	0	0	0	0	NS
Hemorrhage	0	0	0	0	1	0	1	0	NS
Other cancer	2	1	0	1	2	1	0	1	NS
Total	91	80	4	7	147	128	10	9	<.0001
Total related	80	70	4	6	118	104	9	5	<.0001
Patients affected	53				82				.0001
Patients affected by related SAEs	48				68				.0057

Treatment arm	FC (139)				FCA (133)
Grade	All	3	4	5	All	3	4	5	P
Infections, all:	70	63	2	5	81	67	8	6	NS
Neutropenic	28	24	2	2	26	25	1	0	NS
Non-neutropenic	31	31	0	0	27	21	3	3	NS
Opportunistic	11	8	0	3	28	21	4	3	.002
Organ-related	13	10	2	1	36	33	1	2	.0005
Flulike syndrome	3	3	0	0	27	27	0	0	<.0001
Allergy	3	3	0	0	0	0	0	0	NS
Hemorrhage	0	0	0	0	1	0	1	0	NS
Other cancer	2	1	0	1	2	1	0	1	NS
Total	91	80	4	7	147	128	10	9	<.0001
Total related	80	70	4	6	118	104	9	5	<.0001
Patients affected	53				82				.0001
Patients affected by related SAEs	48				68				.0057