Outcome at 3 year post-HSCT by risk factors
| . | Frequency . | OS . | EFS . | CIR . | NRM . |
|---|---|---|---|---|---|
| . | n . | OS % (95%CI) . | EFS % (95%CI) . | CIR % (95%CI) . | NRM % (95%CI) . |
| All patients | 201 | 15 (10-20) | 12 (7-16) | 49 (42-56) | 39 (32-46) |
| Age | |||||
| <40 | 29 | 20 (5-35) | 14 (1-26) | 52 (33-71) | 34 (17-52) |
| 40-50 | 44 | 23 (10-37) | 19 (6-32) | 51 (36-66) | 30 (15-48) |
| 50-60 | 80 | 10 (4-17) | 8 (2-14) | 47 (36-66) | 45 (34-56) |
| >60 | 48 | 10 (0-21) | 11 (1-21) | 48 (32-64) | 40 (26-54) |
| P* | .029 | .1 | .9 | .2 | |
| Date of HSCT | |||||
| Before median† | 100 | 9 (3-15) | 7 (2-12) | 54 (44-64) | 39 (30-49) |
| After median | 101 | 22 (13-31) | 18 (10-26) | 43 (33-53) | 38 (29-48) |
| P* | .048 | .2 | .2 | .9 | |
| CR | |||||
| CR1 | 84 | 22 (13-32) | 18 (10-27) | 57 (46-68) | 25 (15-34) |
| >CR1 | 111 | 9 (3-15) | 7 (2-13) | 41 (32-51) | 51 (41-60) |
| P* | <.001 | <.001 | .08 | <.001 | |
| Missing | 6 | ||||
| Type of abnl(17p) | |||||
| add(17p) | 30 | 20 (4-36) | 20 (6-34) | 53 (35-72) | 27 (10-43) |
| i(17q) | 11 | 18 (0-41) | 9 (0-26) | 55 (22-88) | 36 (3-69) |
| del(17p) | 16 | NA | NA | NA | NA |
| der(17v)(q10;v)/der(17)t(17p;v) | 29 | 19 (2-35) | 14 (0-27) | 31 (12-51) | 53 (34-72) |
| dic(17p;v) | 12 | 25 (1-49) | 17 (0-38) | 42 (11-73) | 42 (11-72) |
| −17 | 86 | 10 (3-17) | 11 (4-18) | 54 (43-65) | 35 (25-46) |
| Balanced t(17p;v) | 4 | NA | NA | NA | NA |
| P* | .2 | .5 | .4 | .2 | |
| Missing | 13 | ||||
| Sub classification of CK | |||||
| <3 abnl. | 18 | 28 (7-48) | 22 (3-41) | 33 (10-56) | 44 (20-69) |
| 3-4 abnl. | 24 | 30 (11-50) | 22 (4-40) | 55 (34-77) | 23 (4-41) |
| >4 abnl. | 151 | 11 (5-16) | 9 (4-13) | 50 (42-58) | 41 (33-49) |
| P* | .01 | .02 | .2 | .1 | |
| Missing§ | 8 | ||||
| MK | |||||
| MK− | 43 | 29 (15-44) | 20 (7-33) | 46 (30-62) | 34 (19-49) |
| MK+ | 155 | 11 (5-16) | 9 (4-14) | 50 (42-58) | 41 (33-48) |
| P* | .003 | .004 | .3 | .3 | |
| Missing | 3 | ||||
| Conditioning regimen | |||||
| RIC | 104 | 16 (8-24) | 13 (6-21) | 44 (34-53) | 42 (32-53) |
| MAC | 70 | 12 (4-20) | 8 (2-15) | 53 (41-65) | 39 (27-51) |
| NMA | 18 | 27 (6-48) | 22 (3-41) | 61 (37-85) | 17 (0-35) |
| P* | .5 | .9 | .07 | .1 | |
| Missing | 9 | ||||
| TBI | |||||
| No TBI | 99 | 13 (5-20) | 12 (5-20) | 47 (37-57) | 40 (29-50) |
| ≤8 Gy TBI | 51 | 21 (9-32) | 18 (7-28) | 53 (39-67) | 29 (17-42) |
| >8 Gy TBI | 42 | 17 (5-28) | 7 (0-15) | 47 (31-62) | 46 (30-62) |
| P* | .3 | .8 | .2 | .2 | |
| Missing | 9 | ||||
| Donor type | |||||
| Sibling | 69 | 17 (8-27) | 16 (7-25) | 49 (37-62) | 34 (22-45) |
| MUD | 86 | 19 (10-27) | 10 (2-18) | 54 (42-66) | 36 (26-47) |
| MMUD | 36 | 10 (0-20) | 10 (0-21) | 44 (28-61) | 45 (28-62) |
| Haplo | 8 | NA | NA | NA | NA |
| Cord blood | 1 | NA | NA | NA | NA |
| P* | .6 | .7 | .6 | .1 | |
| Missing | 1 |
| . | Frequency . | OS . | EFS . | CIR . | NRM . |
|---|---|---|---|---|---|
| . | n . | OS % (95%CI) . | EFS % (95%CI) . | CIR % (95%CI) . | NRM % (95%CI) . |
| All patients | 201 | 15 (10-20) | 12 (7-16) | 49 (42-56) | 39 (32-46) |
| Age | |||||
| <40 | 29 | 20 (5-35) | 14 (1-26) | 52 (33-71) | 34 (17-52) |
| 40-50 | 44 | 23 (10-37) | 19 (6-32) | 51 (36-66) | 30 (15-48) |
| 50-60 | 80 | 10 (4-17) | 8 (2-14) | 47 (36-66) | 45 (34-56) |
| >60 | 48 | 10 (0-21) | 11 (1-21) | 48 (32-64) | 40 (26-54) |
| P* | .029 | .1 | .9 | .2 | |
| Date of HSCT | |||||
| Before median† | 100 | 9 (3-15) | 7 (2-12) | 54 (44-64) | 39 (30-49) |
| After median | 101 | 22 (13-31) | 18 (10-26) | 43 (33-53) | 38 (29-48) |
| P* | .048 | .2 | .2 | .9 | |
| CR | |||||
| CR1 | 84 | 22 (13-32) | 18 (10-27) | 57 (46-68) | 25 (15-34) |
| >CR1 | 111 | 9 (3-15) | 7 (2-13) | 41 (32-51) | 51 (41-60) |
| P* | <.001 | <.001 | .08 | <.001 | |
| Missing | 6 | ||||
| Type of abnl(17p) | |||||
| add(17p) | 30 | 20 (4-36) | 20 (6-34) | 53 (35-72) | 27 (10-43) |
| i(17q) | 11 | 18 (0-41) | 9 (0-26) | 55 (22-88) | 36 (3-69) |
| del(17p) | 16 | NA | NA | NA | NA |
| der(17v)(q10;v)/der(17)t(17p;v) | 29 | 19 (2-35) | 14 (0-27) | 31 (12-51) | 53 (34-72) |
| dic(17p;v) | 12 | 25 (1-49) | 17 (0-38) | 42 (11-73) | 42 (11-72) |
| −17 | 86 | 10 (3-17) | 11 (4-18) | 54 (43-65) | 35 (25-46) |
| Balanced t(17p;v) | 4 | NA | NA | NA | NA |
| P* | .2 | .5 | .4 | .2 | |
| Missing | 13 | ||||
| Sub classification of CK | |||||
| <3 abnl. | 18 | 28 (7-48) | 22 (3-41) | 33 (10-56) | 44 (20-69) |
| 3-4 abnl. | 24 | 30 (11-50) | 22 (4-40) | 55 (34-77) | 23 (4-41) |
| >4 abnl. | 151 | 11 (5-16) | 9 (4-13) | 50 (42-58) | 41 (33-49) |
| P* | .01 | .02 | .2 | .1 | |
| Missing§ | 8 | ||||
| MK | |||||
| MK− | 43 | 29 (15-44) | 20 (7-33) | 46 (30-62) | 34 (19-49) |
| MK+ | 155 | 11 (5-16) | 9 (4-14) | 50 (42-58) | 41 (33-48) |
| P* | .003 | .004 | .3 | .3 | |
| Missing | 3 | ||||
| Conditioning regimen | |||||
| RIC | 104 | 16 (8-24) | 13 (6-21) | 44 (34-53) | 42 (32-53) |
| MAC | 70 | 12 (4-20) | 8 (2-15) | 53 (41-65) | 39 (27-51) |
| NMA | 18 | 27 (6-48) | 22 (3-41) | 61 (37-85) | 17 (0-35) |
| P* | .5 | .9 | .07 | .1 | |
| Missing | 9 | ||||
| TBI | |||||
| No TBI | 99 | 13 (5-20) | 12 (5-20) | 47 (37-57) | 40 (29-50) |
| ≤8 Gy TBI | 51 | 21 (9-32) | 18 (7-28) | 53 (39-67) | 29 (17-42) |
| >8 Gy TBI | 42 | 17 (5-28) | 7 (0-15) | 47 (31-62) | 46 (30-62) |
| P* | .3 | .8 | .2 | .2 | |
| Missing | 9 | ||||
| Donor type | |||||
| Sibling | 69 | 17 (8-27) | 16 (7-25) | 49 (37-62) | 34 (22-45) |
| MUD | 86 | 19 (10-27) | 10 (2-18) | 54 (42-66) | 36 (26-47) |
| MMUD | 36 | 10 (0-20) | 10 (0-21) | 44 (28-61) | 45 (28-62) |
| Haplo | 8 | NA | NA | NA | NA |
| Cord blood | 1 | NA | NA | NA | NA |
| P* | .6 | .7 | .6 | .1 | |
| Missing | 1 |
del(17p), deletion of 17p; der(17)t(17p;v), unbalanced translocation resulting from a break in 17p and a break in a variable partner chromosome; dic(17p;v), dicentric chromosome resulting from a break in 17p and a break in a variable partner chromosome; Gy, Gray; i(17q), isochromosome for the entire long arm of one chromosome 17; MMUD, partially matched unrelated donor; MUD, matched unrelated donor; NA, not available.
P values were calculated using the Gray test for CIR and NRM and the log-rank test for OS and EFS.
The median date of performed transplantations was October 26, 2006.
Deletion of TP53 by FISH only.
Because of the combination of conventional karyotyping and FISH analysis, no exact number of aberrations could be denoted in 8 patients.