Univariate and multivariate analyses for progression-free and overall survival
| Prognostic factors . | Progression-free survival . | Overall survival . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariate analysis . | Univariate analysis . | Multivariate analysis . | |||||
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| GATA-3 positive: | 2.7 (1.6-4.9) | .0004 | 2.8 (1.6-5.0) | .0005 | 2.2 (1.2-4.0) | .01 | 2.0 (1.1-3.7) | .02 |
| PIT high risk (≥3 poor risk features) | 2.6 (1.5-4.5) | .0007 | 2.6 (1.5-4.5) | .0008 | 3.5 (1.9-6.3) | <.0001 | 3.3 (1.8-6.0) | .0001 |
| Prognostic factors . | Progression-free survival . | Overall survival . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariate analysis . | Univariate analysis . | Multivariate analysis . | |||||
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| GATA-3 positive: | 2.7 (1.6-4.9) | .0004 | 2.8 (1.6-5.0) | .0005 | 2.2 (1.2-4.0) | .01 | 2.0 (1.1-3.7) | .02 |
| PIT high risk (≥3 poor risk features) | 2.6 (1.5-4.5) | .0007 | 2.6 (1.5-4.5) | .0008 | 3.5 (1.9-6.3) | <.0001 | 3.3 (1.8-6.0) | .0001 |
The PIT is comprised of 4 adverse prognostic factors: age >60 years, elevated LDH, bone marrow involvement, and stage III/IV disease. PIT, prognostic index in PTCL-U.