Functional annotation* of the representative genes in the molecular signatures of the common PTCL entities
| PTCL subgroups . | Unique genes . | Major functional category . | Gene symbols . |
|---|---|---|---|
| AITL | 21 | Cell morphology/Intracellular signaling | EFNB2,ROBO1,S1PR3,ANK2,LPAR1,SNAP91,SOX8 |
| Cell migration/Vascularization | LPAR1,RAMP3,S1PR3,ROBO1,EFNB2,TUBB2B, SOX8 | ||
| Cell cycle | SOX8, ARHGEF10 | ||
| ATLL | 75 | T-cell homeostasis/activation/differentiation | NOTCH1, ZBTB17,CCNE1,FGF18,MYCN,PTHLH,SMARCA2,WNK1, NKX2-1, CYP26A1, HPSE,CTLA4, MYCN, PELI1,PRKCB, SPAST, ALS2, KIF3B, ZFYVE27 |
| Cell cycle/Proliferation | FGF18,MYCN,NKX2-1,NOTCH1,PTHLH,SMARCA2,CCNE1, GF18, WNK1, CTLA4, PELI1, PRKCB, ZBTB17, HPSE, FNTB, REL-1 | ||
| ALCL | 40 | Cell morphology/Intracellular signaling and interaction | DMRT1,SLC19A21,STK3, PERP, TNFRSF8, TMOD1, BATF3 |
| P53-induced genes | CDC14B, PERP,WDFEY3,TMOD1 | ||
| ALK+ vs ALK– | 29 | Cell cycle/Proliferation | AGT, ALK, ANXA3, BTBD11, CCNA1, DNER, GAS1, HS6ST2, IL1RAP, PCOLCE2, PDE4DIP, SLC16A3, TIAM2, TUBB6, WNT7B, SMOX, TMEM158, NLRP7, ADRB2, GALNT2 |
| Cell morphology/intracellular signaling and interaction | DNER, ADRB2, AGT, TIAM2, HS6ST2, GAS1, IL1RAP, WNT7B, ARHGEF10, HRASLS | ||
| ENKTL | 80 | NK-cell activation/survival | CD244,FASLG,KIR2DL4/LOC100287534,KLRD1,SH2D1B, FASLG |
| NK cell markers | CD244,FASLG,KLRC2,KLRD1,FASLG,NCAM1 | ||
| TBX21 vs GATA3 | 100 | Cell growth/Proliferation | ATP6V0D1,AXL,CD59,CHI3L1,CLTC,COL6A1,CREG1,CTSB,CTSC,CTSS,CYBB,FABP3,FPR1,FTL,GUCA2A,HCK,IFI30,IL13RA1,JAK2,LILRB1,NR1H3,PDXK,PITPNA,PLSCR1,PRDX3,PRKG1PSAP, SLC7A7,SOD2, TCN2,THY1,TYR, UBE2L6, WARS, AXL, FTL, SIRPA, STAT1 |
| TBX21 | T-cell activation/Th1 differentiation | CSF2,IFNG,CD28, STAT1, AXL, CD28, CD40, CD59, CSF2, FTL,IFNG,LILRB1, SIRPA,TBX21 | |
| GATA3 | Cell cycle /proliferation | MSH6, EGR1, CAT, EGR1, CAT, SEPT6, GATA3 |
| PTCL subgroups . | Unique genes . | Major functional category . | Gene symbols . |
|---|---|---|---|
| AITL | 21 | Cell morphology/Intracellular signaling | EFNB2,ROBO1,S1PR3,ANK2,LPAR1,SNAP91,SOX8 |
| Cell migration/Vascularization | LPAR1,RAMP3,S1PR3,ROBO1,EFNB2,TUBB2B, SOX8 | ||
| Cell cycle | SOX8, ARHGEF10 | ||
| ATLL | 75 | T-cell homeostasis/activation/differentiation | NOTCH1, ZBTB17,CCNE1,FGF18,MYCN,PTHLH,SMARCA2,WNK1, NKX2-1, CYP26A1, HPSE,CTLA4, MYCN, PELI1,PRKCB, SPAST, ALS2, KIF3B, ZFYVE27 |
| Cell cycle/Proliferation | FGF18,MYCN,NKX2-1,NOTCH1,PTHLH,SMARCA2,CCNE1, GF18, WNK1, CTLA4, PELI1, PRKCB, ZBTB17, HPSE, FNTB, REL-1 | ||
| ALCL | 40 | Cell morphology/Intracellular signaling and interaction | DMRT1,SLC19A21,STK3, PERP, TNFRSF8, TMOD1, BATF3 |
| P53-induced genes | CDC14B, PERP,WDFEY3,TMOD1 | ||
| ALK+ vs ALK– | 29 | Cell cycle/Proliferation | AGT, ALK, ANXA3, BTBD11, CCNA1, DNER, GAS1, HS6ST2, IL1RAP, PCOLCE2, PDE4DIP, SLC16A3, TIAM2, TUBB6, WNT7B, SMOX, TMEM158, NLRP7, ADRB2, GALNT2 |
| Cell morphology/intracellular signaling and interaction | DNER, ADRB2, AGT, TIAM2, HS6ST2, GAS1, IL1RAP, WNT7B, ARHGEF10, HRASLS | ||
| ENKTL | 80 | NK-cell activation/survival | CD244,FASLG,KIR2DL4/LOC100287534,KLRD1,SH2D1B, FASLG |
| NK cell markers | CD244,FASLG,KLRC2,KLRD1,FASLG,NCAM1 | ||
| TBX21 vs GATA3 | 100 | Cell growth/Proliferation | ATP6V0D1,AXL,CD59,CHI3L1,CLTC,COL6A1,CREG1,CTSB,CTSC,CTSS,CYBB,FABP3,FPR1,FTL,GUCA2A,HCK,IFI30,IL13RA1,JAK2,LILRB1,NR1H3,PDXK,PITPNA,PLSCR1,PRDX3,PRKG1PSAP, SLC7A7,SOD2, TCN2,THY1,TYR, UBE2L6, WARS, AXL, FTL, SIRPA, STAT1 |
| TBX21 | T-cell activation/Th1 differentiation | CSF2,IFNG,CD28, STAT1, AXL, CD28, CD40, CD59, CSF2, FTL,IFNG,LILRB1, SIRPA,TBX21 | |
| GATA3 | Cell cycle /proliferation | MSH6, EGR1, CAT, EGR1, CAT, SEPT6, GATA3 |
Ingenuity software (Ingenuity Systems, Inc.) was used to classify genes into functional categories.