Table 2 Roles of PAR1 and PAR2 in a... | American Society of Hematology

Table 2

Roles of PAR1 and PAR2 in a mouse model of H1N1 infection

Mouse	Results	Conclusion	Laboratory	Reference
PAR2ko mice	Increased survival	PAR2 negatively regulates antiviral responses.	Vogel	40
PAR1ko mice	Decreased CXCL10 expression; increased H1N1 genomes	PAR1 positively regulates the TLR3-IFN-β pathway.	Mackman	15
PAR2ko mice	Increased IFN-γ expression; decreased survival	PAR2 positively regulates IFN-γ expression.	Riteau	45
PAR1ko mice	Decreased inflammation; increased survival	PAR1 increases lung inflammation.	Riteau	77

Mouse	Results	Conclusion	Laboratory	Reference
PAR2ko mice	Increased survival	PAR2 negatively regulates antiviral responses.	Vogel	40
PAR1ko mice	Decreased CXCL10 expression; increased H1N1 genomes	PAR1 positively regulates the TLR3-IFN-β pathway.	Mackman	15
PAR2ko mice	Increased IFN-γ expression; decreased survival	PAR2 positively regulates IFN-γ expression.	Riteau	45
PAR1ko mice	Decreased inflammation; increased survival	PAR1 increases lung inflammation.	Riteau	77