Multivariate Cox regression analysis of patients with MDS/MPN-U
| Variables . | OS . | AMLFS . | ||
|---|---|---|---|---|
| . | HR (95% CI) . | P value . | HR (95% CI) . | P value . |
| LDH (increased) | 2.00 (0.90-4.44) | .0873 | 1.81 (0.86-3.79) | .1163 |
| WBC ≥40 × 109/dL | 1.91 (0.64-5.69) | .2446 | 2.62 (0.96-7.13) | .0583 |
| Platelets ≥ 450 × 109/dL | – | – | – | – |
| 100-450 | 1.05 (0.43-2.56) | .9127 | 0.71 (0.30-1.66) | .4328 |
| <100 | 1.82 (0.67-4.91) | .2330 | 1.10 (0.42-2.86) | .8372 |
| <100 vs 100-450 | 1.73 (0.71-4.22) | .2234 | 1.55 (0.66-3.64) | .3128 |
| Blood myeloid precursors ≥10% | 1.57 (0.44-5.56) | .4815 | 3.19 (0.91-11.10) | .0677 |
| BM blasts ≥5% | 2.02 (0.81-5.01) | .1264 | 2.60 (1.13-5.98) | .0242 |
| PB blasts ≥5% | 0.35 (0.10-1.25) | .1076 | 0.17 (0.04-0.68) | .0125 |
| Cytogenetics 3* | 7.24 (1.60-32.68) | .0100 | 76.62 (10.21-574.66) | <.0001 |
| Dysgranulopoiesis | 1.18 (0.49-2.83) | .7048 | 1.48 (0.62-3.53) | .3704 |
| Variables . | OS . | AMLFS . | ||
|---|---|---|---|---|
| . | HR (95% CI) . | P value . | HR (95% CI) . | P value . |
| LDH (increased) | 2.00 (0.90-4.44) | .0873 | 1.81 (0.86-3.79) | .1163 |
| WBC ≥40 × 109/dL | 1.91 (0.64-5.69) | .2446 | 2.62 (0.96-7.13) | .0583 |
| Platelets ≥ 450 × 109/dL | – | – | – | – |
| 100-450 | 1.05 (0.43-2.56) | .9127 | 0.71 (0.30-1.66) | .4328 |
| <100 | 1.82 (0.67-4.91) | .2330 | 1.10 (0.42-2.86) | .8372 |
| <100 vs 100-450 | 1.73 (0.71-4.22) | .2234 | 1.55 (0.66-3.64) | .3128 |
| Blood myeloid precursors ≥10% | 1.57 (0.44-5.56) | .4815 | 3.19 (0.91-11.10) | .0677 |
| BM blasts ≥5% | 2.02 (0.81-5.01) | .1264 | 2.60 (1.13-5.98) | .0242 |
| PB blasts ≥5% | 0.35 (0.10-1.25) | .1076 | 0.17 (0.04-0.68) | .0125 |
| Cytogenetics 3* | 7.24 (1.60-32.68) | .0100 | 76.62 (10.21-574.66) | <.0001 |
| Dysgranulopoiesis | 1.18 (0.49-2.83) | .7048 | 1.48 (0.62-3.53) | .3704 |
Cytogenetic category 3 (complex and −7/−7q) is compared with category 1 (normal or –Y) combined with category 2 (all other abnormalities).