Prior episodes of HIT
| Pt . | Age, sex at HIT . | Setting . | 4Ts . | HIT-associated thrombosis or other sequelae . | Serotonin release, % . | EIA-GAM (OD units) . | EIA-G (OD units) . | HIT . |
|---|---|---|---|---|---|---|---|---|
| 1 | 55, M | DVT treatment | 7 | DVT extends | 100 | ND | 2.65 | Definite |
| 2 | 65, F | General surgery | 7 | Limb artery | 100 | ND | 2.61 | Definite |
| 3 | 60, M | Cardiac surgery | 8 | Adrenal vein | 85 | 2.82 | 2.65 | Definite |
| 4 | 48, M | Vascular surgery | 6 | Nil | 84 | 1.50 | 2.56 | Definite |
| 5 | 60, F | Vascular surgery | 8 | Limb ischemia | ND | Pos | ND | Probable |
| 6 | 65, M | Cardiac surgery | 7 | Anaphylactoid | 60 | 1.66 | 2.04 | Definite |
| 7 | 75, F | Medical prophylaxis | 8 | DVT, PE | 93 | ND | ND | Definite |
| 8 | 51, M | Vascular surgery | 6 | Limb ischemia | 98 | ND | 3.10 | Definite |
| 9 | 77, F | Medical prophylaxis | 7 | MI | 99 | ND | 2.24 | Definite |
| 10 | 73, M | Vascular surgery | 5 | MI | 100 | ND | 2.56 | Definite |
| 11 | 72, M | Cardiac surgery | 7 | Anaphylactoid | 100 | ND | 2.31 | Definite |
| 12 | 74, F | Vascular surgery | 6 | Nil | 100 | 2.91 | 2.51 | Definite |
| 13 | 48, F | PE treatment | 4 | Nil | ND | Pos | ND | Probable |
| 14 | 66, M | Thoracic surgery | 7 | PE | ND | Pos | ND | Probable |
| 15 | 57, M | Medical prophylaxis | 6 | Mesenteric vein | 85 | ND | 2.54 | Definite |
| 16 | 61, M | DVT treatment | 4 | MI, DVT | 93 | ND | 1.85 | Definite |
| 17 | 68, M | Cardiac surgery | 8 | DVT, PE | ND | >2.00 | ND | Definite |
| 18 | 48, M | Vascular surgery | 7 | MI, CVA, PE | ND | Pos | ND | Probable |
| 19 | 62, M | Hemodialysis | 4 | Nil | 82 | ND | ND | Definite |
| 20 | 54, M | Medical (SBE treatment) | 5 | Nil | 100 | ND | 2.45 | Definite |
| Pt . | Age, sex at HIT . | Setting . | 4Ts . | HIT-associated thrombosis or other sequelae . | Serotonin release, % . | EIA-GAM (OD units) . | EIA-G (OD units) . | HIT . |
|---|---|---|---|---|---|---|---|---|
| 1 | 55, M | DVT treatment | 7 | DVT extends | 100 | ND | 2.65 | Definite |
| 2 | 65, F | General surgery | 7 | Limb artery | 100 | ND | 2.61 | Definite |
| 3 | 60, M | Cardiac surgery | 8 | Adrenal vein | 85 | 2.82 | 2.65 | Definite |
| 4 | 48, M | Vascular surgery | 6 | Nil | 84 | 1.50 | 2.56 | Definite |
| 5 | 60, F | Vascular surgery | 8 | Limb ischemia | ND | Pos | ND | Probable |
| 6 | 65, M | Cardiac surgery | 7 | Anaphylactoid | 60 | 1.66 | 2.04 | Definite |
| 7 | 75, F | Medical prophylaxis | 8 | DVT, PE | 93 | ND | ND | Definite |
| 8 | 51, M | Vascular surgery | 6 | Limb ischemia | 98 | ND | 3.10 | Definite |
| 9 | 77, F | Medical prophylaxis | 7 | MI | 99 | ND | 2.24 | Definite |
| 10 | 73, M | Vascular surgery | 5 | MI | 100 | ND | 2.56 | Definite |
| 11 | 72, M | Cardiac surgery | 7 | Anaphylactoid | 100 | ND | 2.31 | Definite |
| 12 | 74, F | Vascular surgery | 6 | Nil | 100 | 2.91 | 2.51 | Definite |
| 13 | 48, F | PE treatment | 4 | Nil | ND | Pos | ND | Probable |
| 14 | 66, M | Thoracic surgery | 7 | PE | ND | Pos | ND | Probable |
| 15 | 57, M | Medical prophylaxis | 6 | Mesenteric vein | 85 | ND | 2.54 | Definite |
| 16 | 61, M | DVT treatment | 4 | MI, DVT | 93 | ND | 1.85 | Definite |
| 17 | 68, M | Cardiac surgery | 8 | DVT, PE | ND | >2.00 | ND | Definite |
| 18 | 48, M | Vascular surgery | 7 | MI, CVA, PE | ND | Pos | ND | Probable |
| 19 | 62, M | Hemodialysis | 4 | Nil | 82 | ND | ND | Definite |
| 20 | 54, M | Medical (SBE treatment) | 5 | Nil | 100 | ND | 2.45 | Definite |
For 5 of the 20 patients (patients 5, 13, 14, 17, and 18), an SRA was not performed because the previous episode of HIT occurred at a non-Hamilton hospital.
CVA, cerebrovascular accident (thrombotic); EIA-G, EIA that detects antibodies against IgG only; GAM, EIA that detects antibodies against IgG, IgA, and IgM antibodies; F, female; M, male; MI, myocardial infarction; ND, not done; Pos, positive; Pt, patient; SBE, subacute bacterial endocarditis.