Characteristics of pediatric AML patients with RUNX1 aberrations
| Gender . | Age at dx (y) . | FAB-type . | Karyotype sample . | Other aberrations . | RUNX1 mutation . | Effect . | RUNX1 protein domain . | Event1 . | Time dx-event1 (mo) . | Time dx-death (mo) . | Cause of death . | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Male | 5.0 | M1 | 45,XY,-7[13]/45,idem,der(18)t(8,18)(q21;q22)[2] | — | c.179 ins GG | FS | NRDBn/ NRHn | Nonremitter | 0.0 | Alive | — |
| 2 | Male | 2.6 | M5 | 46,XY,t(16,21)(p11;q22)/ 46,idem,i(22)(q10)/ 46,XY | — | c.292delC | FS | RUNT | Relapse | 15.8 | 26.3 | Leukemia |
| 3 | Male | 12.3 | M3 | 46,XY[17] | FLT3-ITD & WT1 | c.328 A>C | MS | RUNT | Nonremitter | 0.0 | 15.1 | Infection |
| 4 | Male | 3.9 | M1 | 46,XY, aberrant(pseudodiploid)[9] ISH:MLL&inv(16) notaberrant | NRAS | c.424_425insGG | FS | RUNT | Relapse | 11.4 | 14.9 | Leukemia |
| 5 | Male | 13.8 | M1 | 46,XY,add(8)(q22),add(16)(p13.1)[3]/ 46,XY,add(8)(q22)[13] | — | c.424_425insGGG | IF | RUNT | Relapse | 2.3 | 7.0 | Leukemia |
| 6 | Female | 14.1 | M4 | 46,XX,-7[21] | NRAS | c.497G>A | MS | RUNT | Relapse | 25.3 | 43.3 | Toxic, neurological syndrome |
| 7 | Female | 3.9 | M1 | 46,XX,del(5)(q31q34),del(16)(?q22)[1]/ 46,XX[4] | — | c.507_508ins11 | FS | RUNT | Nonremitter | 0.0 | 3.2 | Leukemia |
| 8 | Female | 15.4 | M1 | 46,XX | NPM1 | c.1085 C>T | MS | TAD | Early death | 0.0 | 0.0 | Leukemia |
| 9 | Male | 2.1 | M7 | 49,XY,+16,del(17)(p11),+19,+21,+21,-22[5]/ 46,XY [22] | — | c.1190 A>G | MS | TID | None | — | Alive | — |
| Gender . | Age at dx (y) . | FAB-type . | Karyotype sample . | Other aberrations . | RUNX1 mutation . | Effect . | RUNX1 protein domain . | Event1 . | Time dx-event1 (mo) . | Time dx-death (mo) . | Cause of death . | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Male | 5.0 | M1 | 45,XY,-7[13]/45,idem,der(18)t(8,18)(q21;q22)[2] | — | c.179 ins GG | FS | NRDBn/ NRHn | Nonremitter | 0.0 | Alive | — |
| 2 | Male | 2.6 | M5 | 46,XY,t(16,21)(p11;q22)/ 46,idem,i(22)(q10)/ 46,XY | — | c.292delC | FS | RUNT | Relapse | 15.8 | 26.3 | Leukemia |
| 3 | Male | 12.3 | M3 | 46,XY[17] | FLT3-ITD & WT1 | c.328 A>C | MS | RUNT | Nonremitter | 0.0 | 15.1 | Infection |
| 4 | Male | 3.9 | M1 | 46,XY, aberrant(pseudodiploid)[9] ISH:MLL&inv(16) notaberrant | NRAS | c.424_425insGG | FS | RUNT | Relapse | 11.4 | 14.9 | Leukemia |
| 5 | Male | 13.8 | M1 | 46,XY,add(8)(q22),add(16)(p13.1)[3]/ 46,XY,add(8)(q22)[13] | — | c.424_425insGGG | IF | RUNT | Relapse | 2.3 | 7.0 | Leukemia |
| 6 | Female | 14.1 | M4 | 46,XX,-7[21] | NRAS | c.497G>A | MS | RUNT | Relapse | 25.3 | 43.3 | Toxic, neurological syndrome |
| 7 | Female | 3.9 | M1 | 46,XX,del(5)(q31q34),del(16)(?q22)[1]/ 46,XX[4] | — | c.507_508ins11 | FS | RUNT | Nonremitter | 0.0 | 3.2 | Leukemia |
| 8 | Female | 15.4 | M1 | 46,XX | NPM1 | c.1085 C>T | MS | TAD | Early death | 0.0 | 0.0 | Leukemia |
| 9 | Male | 2.1 | M7 | 49,XY,+16,del(17)(p11),+19,+21,+21,-22[5]/ 46,XY [22] | — | c.1190 A>G | MS | TID | None | — | Alive | — |
dx, diagnosis.