Efficacy parameters
| . | Intent-to-treat . | LEN refractory . | LEN and BORT refractory . | |||
|---|---|---|---|---|---|---|
| POM+LoDEX (n = 113) . | POM alone (n = 108) . | POM+LoDEX (n = 88) . | POM alone (n = 86) . | POM+LoDEX (n = 70) . | POM alone (n = 66) . | |
| Median PFS, months | 4.2 | 2.7 | 3.8 | 2.2 | 3.8 | 2.0 |
| Median OS, months | 16.5 | 13.6 | 16.0 | 12.0 | 13.4 | 12.5 |
| ORR (≥PR), % | 33 | 18 | 30 | 21 | 31 | 21 |
| ≥MR, % | 45 | 31 | 42 | 31 | 46 | 33 |
| CR | 3 | 2 | 0 | 1 | 0 | 1 |
| PR | 30 | 16 | 30 | 20 | 31 | 20 |
| MR | 12 | 13 | 13 | 11 | 14 | 12 |
| SD, % | 37 | 48 | 41 | 47 | 39 | 42 |
| Median time-to-response (≥PR), months | 1.9 | 4.3 | 1.9 | 4.6 | 1.6 | 4.6 |
| Median duration of response (≥PR), months | 8.3 | 10.7 | 7.7 | 8.8 | 6.5 | 11.4 |
| Median duration of ≥MR, months | 7.7 | 7.4 | 6.2 | 6.7 | 6.2 | 6.7 |
| . | Intent-to-treat . | LEN refractory . | LEN and BORT refractory . | |||
|---|---|---|---|---|---|---|
| POM+LoDEX (n = 113) . | POM alone (n = 108) . | POM+LoDEX (n = 88) . | POM alone (n = 86) . | POM+LoDEX (n = 70) . | POM alone (n = 66) . | |
| Median PFS, months | 4.2 | 2.7 | 3.8 | 2.2 | 3.8 | 2.0 |
| Median OS, months | 16.5 | 13.6 | 16.0 | 12.0 | 13.4 | 12.5 |
| ORR (≥PR), % | 33 | 18 | 30 | 21 | 31 | 21 |
| ≥MR, % | 45 | 31 | 42 | 31 | 46 | 33 |
| CR | 3 | 2 | 0 | 1 | 0 | 1 |
| PR | 30 | 16 | 30 | 20 | 31 | 20 |
| MR | 12 | 13 | 13 | 11 | 14 | 12 |
| SD, % | 37 | 48 | 41 | 47 | 39 | 42 |
| Median time-to-response (≥PR), months | 1.9 | 4.3 | 1.9 | 4.6 | 1.6 | 4.6 |
| Median duration of response (≥PR), months | 8.3 | 10.7 | 7.7 | 8.8 | 6.5 | 11.4 |
| Median duration of ≥MR, months | 7.7 | 7.4 | 6.2 | 6.7 | 6.2 | 6.7 |
CR, complete response; MR, minimal response.