Table 2

Frequency of HLA-B ligand genotypes in childhood ALL cases and controls in all subjects (total), Hispanics, and non-Hispanic whites: CCLS

HLA-B genotypeCases (%)Controls (%)POR (95% CI)
Total     
 n 210 (100) 228 (100)   
 Bw6/Bw6 95 (45.2) 112 (49.1)   
 Bw4/Bw6 91 (43.3) 100 (43.9) .17 1.23 (0.92-1.64) 
 Bw4/Bw4 24 (11.4) 16 (7.0)   
Hispanics     
 n 112 (100) 126 (100)   
 Bw6/Bw6 55 (49.1) 66 (52.4)   
 Bw4/Bw6 52 (46.4) 52 (41.3) .82 1.05 (0.69-1.61) 
 Bw4/Bw4 5 (4.5) 8 (6.4)   
Non-Hispanic whites     
 n 76 (100) 85 (100)   
 Bw6/Bw6 29 (38.2) 42 (49.4)   
 Bw4/Bw6 32 (42.1) 38 (44.7) .02*† 1.74 (1.09-2.81)* 
 Bw4/Bw4 15 (19.7) 5 (5.9) .01*‡ 3.93 (1.44-12.64)* 
HLA-B genotypeCases (%)Controls (%)POR (95% CI)
Total     
 n 210 (100) 228 (100)   
 Bw6/Bw6 95 (45.2) 112 (49.1)   
 Bw4/Bw6 91 (43.3) 100 (43.9) .17 1.23 (0.92-1.64) 
 Bw4/Bw4 24 (11.4) 16 (7.0)   
Hispanics     
 n 112 (100) 126 (100)   
 Bw6/Bw6 55 (49.1) 66 (52.4)   
 Bw4/Bw6 52 (46.4) 52 (41.3) .82 1.05 (0.69-1.61) 
 Bw4/Bw4 5 (4.5) 8 (6.4)   
Non-Hispanic whites     
 n 76 (100) 85 (100)   
 Bw6/Bw6 29 (38.2) 42 (49.4)   
 Bw4/Bw6 32 (42.1) 38 (44.7) .02*† 1.74 (1.09-2.81)* 
 Bw4/Bw4 15 (19.7) 5 (5.9) .01*‡ 3.93 (1.44-12.64)* 

P values and ORs (95% CI) calculated using unconditional logistic regression analysis.

*

Significant P values and ORs.

†

P value and OR for overall HLA-B genotype.

‡

P value and OR for Bw4 homozygosity.

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