Table 2 Calculation of relative risk... | American Society of Hematology

Table 2

Calculation of relative risk

Study	Calculation	Risk definition by calculation
Sokal et al. 1984⁷	Exp 0.0116 × (age − 43.4) + 0.0345 × (spleen − 7.51) + 0.188 × [(platelet count ÷ 700)² − 0.563] + 0.0887 × (blast cells − 2.10)	Low risk: <0.8
		Intermediate risk: 0.8-1.2
		High risk: >1.2
Euro	0.666 when age ≥50 y + (0.042 × spleen) + 1.0956 when platelet count >1500 × 10⁹L + (0.0584 × blast cells) + 0.20399 when basophils >3% + (0.0413 × eosinophils) × 100	Low risk: ≤780
Hasford et al. 1998⁸		Intermediate risk: 781-1480
Hasford et al. 1998⁸		High risk: >1480
EUTOS	Spleen × 4 + basophils × 7	Low risk: ≤87
Hasford et al. 2011⁹	Spleen × 4 + basophils × 7	High risk: >87

Study	Calculation	Risk definition by calculation
Sokal et al. 1984⁷	Exp 0.0116 × (age − 43.4) + 0.0345 × (spleen − 7.51) + 0.188 × [(platelet count ÷ 700)² − 0.563] + 0.0887 × (blast cells − 2.10)	Low risk: <0.8
		Intermediate risk: 0.8-1.2
		High risk: >1.2
Euro	0.666 when age ≥50 y + (0.042 × spleen) + 1.0956 when platelet count >1500 × 10⁹L + (0.0584 × blast cells) + 0.20399 when basophils >3% + (0.0413 × eosinophils) × 100	Low risk: ≤780
Hasford et al. 1998⁸		Intermediate risk: 781-1480
Hasford et al. 1998⁸		High risk: >1480
EUTOS	Spleen × 4 + basophils × 7	Low risk: ≤87
Hasford et al. 2011⁹	Spleen × 4 + basophils × 7	High risk: >87

Age is given in years. Spleen is given in centimeters below the costal margin (maximum distance). Blast cells, eosinophils, and basophils are given in percent of peripheral blood differential. All values must be collected before any treatment. To calculate Sokal and Euro risk score, go to http://www.leukemia-net.org/content/leukemias/cml/cml_score/index_eng.html. To calculate EUTOS risk score, go to http://www.leukemia-net.org/content/leukemias/cml/eutos_score/index_eng.html.