Hemodynamic parameters in the skull bone marrow venules of control and eNOS-deficient mice infused with sRBCs
| . | Venular diameter (μm) . | Mean RBC velocity (μm/s) . | Calculated WSR (s−1) . |
|---|---|---|---|
| Control mice | |||
| Normoxia | 29.7 ± 1.9 | 236.8 ± 40.4 | 63.7 ± 8.8 |
| Hypoxia | 26.1 ± 1.0 | 109.9 ± 12.4*** | 33.7 ± 3.5** |
| eNOS-deficient mice | |||
| Normoxia | 28.5 ± 2.6 | 217.5 ± 23.0 | 70.0 ± 11.6 |
| Hypoxia | 33.7 ± 3.3 | 117.3 ± 13.9*** | 29.4 ± 3.4*** |
| Hypoxia with 4 ppm NO | 27.5 ± 1.7 | 190.7 ± 13.0* | 56.8 ± 4.1* |
| Hypoxia with 20 ppm NO | 30.5 ± 2.2 | 167.2 ± 16.9* | 50.6 ± 6.6* |
| . | Venular diameter (μm) . | Mean RBC velocity (μm/s) . | Calculated WSR (s−1) . |
|---|---|---|---|
| Control mice | |||
| Normoxia | 29.7 ± 1.9 | 236.8 ± 40.4 | 63.7 ± 8.8 |
| Hypoxia | 26.1 ± 1.0 | 109.9 ± 12.4*** | 33.7 ± 3.5** |
| eNOS-deficient mice | |||
| Normoxia | 28.5 ± 2.6 | 217.5 ± 23.0 | 70.0 ± 11.6 |
| Hypoxia | 33.7 ± 3.3 | 117.3 ± 13.9*** | 29.4 ± 3.4*** |
| Hypoxia with 4 ppm NO | 27.5 ± 1.7 | 190.7 ± 13.0* | 56.8 ± 4.1* |
| Hypoxia with 20 ppm NO | 30.5 ± 2.2 | 167.2 ± 16.9* | 50.6 ± 6.6* |
All data were expressed as means ± SEM. Values calculated from 6 mice for each group. ***P < .001 compared with corresponding normoxia; **P < .01 compared with corresponding normoxia; *P < .05 compared with corresponding hypoxia without NO.