Characteristics of the whole CLL series of patients harboring solely subclonal TP53 mutations, and of patients harboring clonal TP53 mutations
| Characteristics* . | All (n = 309) . | Solely subclonal TP53 mutations (n = 18) . | Clonal TP53 mutations (n = 28) . | . | |||
|---|---|---|---|---|---|---|---|
| N . | % . | n . | % . | N . | % . | P‡ . | |
| Age >70 y | 160 | 51.8 | 11 | 61.1 | 19 | 67.9 | .6391 |
| Male | 165 | 53.4 | 10 | 55.6 | 19 | 67.9 | .3988 |
| Binet A | 245 | 79.3 | 13 | 72.2 | 16 | 57.1 | .5848 |
| Binet B | 37 | 12.0 | 2 | 11.1 | 5 | 17.9 | |
| Binet C | 27 | 8.7 | 3 | 16.7 | 7 | 25.0 | |
| IGHV identity >98%† | 108 | 35.5 | 6 | 35.3 | 13 | 46.4 | .4634 |
| Stereotyped VH CDR3† | 68 | 22.4 | 6 | 35.3 | 8 | 28.6 | .6367 |
| 13q14 deletion | 158 | 51.1 | 12 | 66.7 | 17 | 60.7 | .6831 |
| Trisomy 12 | 64 | 20.7 | 5 | 27.8 | 3 | 10.7 | .2316 |
| 11q22-q23 deletion | 24 | 7.8 | 2 | 11.1 | 2 | 7.1 | .6386 |
| 17p13 deletion | 29 | 9.4 | 3 | 16.7 | 22 | 78.6 | <.0001 |
| NOTCH1 mutations | 34 | 11.0 | 1 | 5.6 | 3 | 10.7 | 1.00 |
| SF3B1 mutations | 22 | 7.1 | 3 | 16.7 | 3 | 10.7 | .6655 |
| BIRC3 deletion | 13 | 4.2 | 1 | 5.6 | 2 | 7.1 | 1.00 |
| BIRC3 mutations | 7 | 2.3 | 0 | 0 | 0 | 0 | — |
| BIRC3 disruption | 17 | 5.5 | 1 | 5.6 | 2 | 7.1 | 1.00 |
| MYD88 mutations | 10 | 3.2 | 0 | 0 | 0 | 0 | — |
| Characteristics* . | All (n = 309) . | Solely subclonal TP53 mutations (n = 18) . | Clonal TP53 mutations (n = 28) . | . | |||
|---|---|---|---|---|---|---|---|
| N . | % . | n . | % . | N . | % . | P‡ . | |
| Age >70 y | 160 | 51.8 | 11 | 61.1 | 19 | 67.9 | .6391 |
| Male | 165 | 53.4 | 10 | 55.6 | 19 | 67.9 | .3988 |
| Binet A | 245 | 79.3 | 13 | 72.2 | 16 | 57.1 | .5848 |
| Binet B | 37 | 12.0 | 2 | 11.1 | 5 | 17.9 | |
| Binet C | 27 | 8.7 | 3 | 16.7 | 7 | 25.0 | |
| IGHV identity >98%† | 108 | 35.5 | 6 | 35.3 | 13 | 46.4 | .4634 |
| Stereotyped VH CDR3† | 68 | 22.4 | 6 | 35.3 | 8 | 28.6 | .6367 |
| 13q14 deletion | 158 | 51.1 | 12 | 66.7 | 17 | 60.7 | .6831 |
| Trisomy 12 | 64 | 20.7 | 5 | 27.8 | 3 | 10.7 | .2316 |
| 11q22-q23 deletion | 24 | 7.8 | 2 | 11.1 | 2 | 7.1 | .6386 |
| 17p13 deletion | 29 | 9.4 | 3 | 16.7 | 22 | 78.6 | <.0001 |
| NOTCH1 mutations | 34 | 11.0 | 1 | 5.6 | 3 | 10.7 | 1.00 |
| SF3B1 mutations | 22 | 7.1 | 3 | 16.7 | 3 | 10.7 | .6655 |
| BIRC3 deletion | 13 | 4.2 | 1 | 5.6 | 2 | 7.1 | 1.00 |
| BIRC3 mutations | 7 | 2.3 | 0 | 0 | 0 | 0 | — |
| BIRC3 disruption | 17 | 5.5 | 1 | 5.6 | 2 | 7.1 | 1.00 |
| MYD88 mutations | 10 | 3.2 | 0 | 0 | 0 | 0 | — |
IGHV, immunoglobulin heavy variable gene; CDR3, complementarity determining region 3.
IGHV mutation status was assessable in 304 patients; 5 patients lacked productive IGHV-IGHD-IGHJ rearrangements.
P value for the comparison between cases harboring solely subclonal TP53 mutations vs clonal TP53 mutations.