ORs for severe malaria by Hp genotype stratified by α+thalassemia genotype
| α+Thalassemia . | Hp . | Severe malaria (n) . | Controls (n) . | OR (95% CI) . | P . |
|---|---|---|---|---|---|
| αα/αα | Hp1-1 | 126 | 133 | 1.0 (Reference) | Reference |
| Hp2-1 | 170 | 188 | 0.93 (0.67-1.30) | .70 | |
| Hp2-2 | 102 | 121 | 0.89 (0.61-1.30) | .55 | |
| -α/αα and -α/-α | Hp1-1 | 186 | 228 | 0.87 (0.63-1.20) | .39 |
| Hp2-1 | 253 | 402 | 0.63 (0.47-0.86) | .003 | |
| Hp2-2 | 159 | 148 | 1.10 (0.78-1.55) | .60 |
| α+Thalassemia . | Hp . | Severe malaria (n) . | Controls (n) . | OR (95% CI) . | P . |
|---|---|---|---|---|---|
| αα/αα | Hp1-1 | 126 | 133 | 1.0 (Reference) | Reference |
| Hp2-1 | 170 | 188 | 0.93 (0.67-1.30) | .70 | |
| Hp2-2 | 102 | 121 | 0.89 (0.61-1.30) | .55 | |
| -α/αα and -α/-α | Hp1-1 | 186 | 228 | 0.87 (0.63-1.20) | .39 |
| Hp2-1 | 253 | 402 | 0.63 (0.47-0.86) | .003 | |
| Hp2-2 | 159 | 148 | 1.10 (0.78-1.55) | .60 |
ORs were derived by logistic regression analyses adjusted for gender, ethnicity, and sickle status. Hp1-1 inherited with αα/αα was the reference type with an OR for severe malaria of 1.0.