HRs (95% CIs) for extramedullary disease at diagnosis, MRD level at time of transplant, and aGVHD status in a Cox regression model controlling for disease risk and donor type
| . | Relapse . | TRM . | EFS . | OS . |
|---|---|---|---|---|
| Extramedullary disease at diagnosis | ||||
| No | 1 | 1 | 1 | 1 |
| Yes | 1.82 (0.85-3.91) | 2.51 (0.79-7.96) | 1.98 (1.05-3.72) | 2.22 (1.11-4.44) |
| P | .12 | .12 | .03 | .02 |
| MRD status pretransplant | ||||
| Negative | 1 | 1 | 1 | 1 |
| Positive, <0.1% | 1.59 (0.52-4.82) | 2.30 (0.43-12.4) | 1.66 (0.67-4.13) | 1.63 (0.59-4.44) |
| Positive, ≥0.1% | 3.30 (1.32-8.22) | 1.31 (0.33-5.24) | 2.23 (1.06-4.70) | 1.73 (0.75-4.00) |
| P | .04 | .62 | .09 | .35 |
| aGVHD* | ||||
| None | 1 | 1 | 1 | 1 |
| Grade 1-3 | 0.44 (0.20-0.95) | 0.64 (0.22-1.90) | 0.46 (0.25-0.87) | 0.55 (0.28-1.09) |
| P | .04 | .42 | .02 | .08 |
| Grade 4 | 0 (–) | 6.39 (1.85-22.1) | 2.56 (0.97-6.75) | 2.96 (1.09-8.07) |
| P | .99 | .003 | .06 | .03 |
| . | Relapse . | TRM . | EFS . | OS . |
|---|---|---|---|---|
| Extramedullary disease at diagnosis | ||||
| No | 1 | 1 | 1 | 1 |
| Yes | 1.82 (0.85-3.91) | 2.51 (0.79-7.96) | 1.98 (1.05-3.72) | 2.22 (1.11-4.44) |
| P | .12 | .12 | .03 | .02 |
| MRD status pretransplant | ||||
| Negative | 1 | 1 | 1 | 1 |
| Positive, <0.1% | 1.59 (0.52-4.82) | 2.30 (0.43-12.4) | 1.66 (0.67-4.13) | 1.63 (0.59-4.44) |
| Positive, ≥0.1% | 3.30 (1.32-8.22) | 1.31 (0.33-5.24) | 2.23 (1.06-4.70) | 1.73 (0.75-4.00) |
| P | .04 | .62 | .09 | .35 |
| aGVHD* | ||||
| None | 1 | 1 | 1 | 1 |
| Grade 1-3 | 0.44 (0.20-0.95) | 0.64 (0.22-1.90) | 0.46 (0.25-0.87) | 0.55 (0.28-1.09) |
| P | .04 | .42 | .02 | .08 |
| Grade 4 | 0 (–) | 6.39 (1.85-22.1) | 2.56 (0.97-6.75) | 2.96 (1.09-8.07) |
| P | .99 | .003 | .06 | .03 |