Configurations of allosteric disulfide bonds in blood proteins and their mechanism of cleavage
| Protein . | Disulfide cysteines . | Disulfide bond configuration (Protein Data Bank identifier) . | Cleavage mechanism . | Reference . |
|---|---|---|---|---|
| Angiotensinogen | 18-138 | −/+RHHook (2WXW) | Oxidoreductase | 43 |
| β2-glycoprotein I | 288-326 | −/+RHHook (1C1Z) | Oxidoreductase | 34, 35 |
| IL-2 receptor subunit γ (CD132) | 183-232 | −LHHook (2ERJ) | Oxidoreductase | 46 |
| Plasminogen | 462-541 | −/+RHHook (4DUR) | Oxidoreductase? | 41, 51 |
| 512-536 | −LHHook (4DUR) | Thiol-disulfide exchange | ||
| β3 integrin (αIIbβ3) | 523-544 | −LHHook (3FCS) | Oxidoreductase? | 83 |
| 560-583 | −LHHook (3FCS) | |||
| β3 integrin (αvβ3) | 523-544 | −RHStaple (3IJE) | Oxidoreductase? | 83 |
| 560-583 | −LHHook (3IJE) | |||
| Tissue factor | 186-209 | −RHStaple (1BOY) | Oxidoreductase | 98 |
| Factor XI | 362-482 | −/+RHHook (2F83) | Oxidoreductase | 89 |
| βII-tryptase | 220-248 | −RHHook and | Oxidoreductase | 36 |
| −RHSpiral (3FPZ) | ||||
| VEGF-C | 156-165 | −LHHook (2X1W) | Thiol-disulfide exchange | 93 |
| Protein . | Disulfide cysteines . | Disulfide bond configuration (Protein Data Bank identifier) . | Cleavage mechanism . | Reference . |
|---|---|---|---|---|
| Angiotensinogen | 18-138 | −/+RHHook (2WXW) | Oxidoreductase | 43 |
| β2-glycoprotein I | 288-326 | −/+RHHook (1C1Z) | Oxidoreductase | 34, 35 |
| IL-2 receptor subunit γ (CD132) | 183-232 | −LHHook (2ERJ) | Oxidoreductase | 46 |
| Plasminogen | 462-541 | −/+RHHook (4DUR) | Oxidoreductase? | 41, 51 |
| 512-536 | −LHHook (4DUR) | Thiol-disulfide exchange | ||
| β3 integrin (αIIbβ3) | 523-544 | −LHHook (3FCS) | Oxidoreductase? | 83 |
| 560-583 | −LHHook (3FCS) | |||
| β3 integrin (αvβ3) | 523-544 | −RHStaple (3IJE) | Oxidoreductase? | 83 |
| 560-583 | −LHHook (3IJE) | |||
| Tissue factor | 186-209 | −RHStaple (1BOY) | Oxidoreductase | 98 |
| Factor XI | 362-482 | −/+RHHook (2F83) | Oxidoreductase | 89 |
| βII-tryptase | 220-248 | −RHHook and | Oxidoreductase | 36 |
| −RHSpiral (3FPZ) | ||||
| VEGF-C | 156-165 | −LHHook (2X1W) | Thiol-disulfide exchange | 93 |