Demographic, hematologic, and clinical features at diagnosis of patients with ET, subdivided according to JAK2 or CALR mutation status, and of patients with PV
| . | ET . | PV (C) . | P . | |||
|---|---|---|---|---|---|---|
| . | CALR mutated (A) . | JAK2 mutated (B) . | ||||
| No. . | 176 . | 466 . | 468 . | (A) vs (B) . | (B) vs (C) . | (A) vs (C) . |
| Sex (male/female) | 90/86 (51%/49%) | 167/299 (36%/64%) | 233/235 (50%/50%) | .001 | <.001 | .791 |
| Age at onset, years, median (range) | 45 (15-83) | 50 (15-92) | 57 (13-86) | .001 | <.001 | <.001 |
| Hemoglobin, g/dL, median (range) | 13.8 (11.3-17.6) | 14.4 (10-17.7) | 18.2 (15.0-24.0) | <.001 | <.001 | <.001 |
| WBC count, ×109/L, median (range) | 8.0 (4.0-17.9) | 9.0 (4.0-28.0) | 10.0 (3.4-55.3) | <.001 | <.001 | <.001 |
| PLT count, ×109/L, median (range) | 883 (500-3000) | 700 (456-2148) | 464 (109-1472) | <.001 | <.001 | <.001 |
| Serum erythropoietin, mU/mL, median (range) | 9.4 (1.2-27) | 4.7 (0-47) | 2.7 (0-66) | <.001 | <.001 | <.001 |
| Splenomegaly, no. (%) | 4 (2.3%) | 30 (6.4%) | 105 (22.4%) | .046 | <.001 | <.001 |
| Lactate dehydrogenase, mU/mL, median (range) | 199 (78-472) | 200 (77-540) | 217 (104-758) | .83 | <.001 | .003 |
| Circulating CD34+ cells, ×106/L, median (range) | 4.1 (0.6-18) | 4 (0-15.3) | 3.4 (0-261.3) | .50 | .037 | .039 |
| Thrombosis at diagnosis, no. (%) | 5 (2.8%) | 33 (7.1%) | 49 (10.5%) | .059 | .082 | .001 |
| . | ET . | PV (C) . | P . | |||
|---|---|---|---|---|---|---|
| . | CALR mutated (A) . | JAK2 mutated (B) . | ||||
| No. . | 176 . | 466 . | 468 . | (A) vs (B) . | (B) vs (C) . | (A) vs (C) . |
| Sex (male/female) | 90/86 (51%/49%) | 167/299 (36%/64%) | 233/235 (50%/50%) | .001 | <.001 | .791 |
| Age at onset, years, median (range) | 45 (15-83) | 50 (15-92) | 57 (13-86) | .001 | <.001 | <.001 |
| Hemoglobin, g/dL, median (range) | 13.8 (11.3-17.6) | 14.4 (10-17.7) | 18.2 (15.0-24.0) | <.001 | <.001 | <.001 |
| WBC count, ×109/L, median (range) | 8.0 (4.0-17.9) | 9.0 (4.0-28.0) | 10.0 (3.4-55.3) | <.001 | <.001 | <.001 |
| PLT count, ×109/L, median (range) | 883 (500-3000) | 700 (456-2148) | 464 (109-1472) | <.001 | <.001 | <.001 |
| Serum erythropoietin, mU/mL, median (range) | 9.4 (1.2-27) | 4.7 (0-47) | 2.7 (0-66) | <.001 | <.001 | <.001 |
| Splenomegaly, no. (%) | 4 (2.3%) | 30 (6.4%) | 105 (22.4%) | .046 | <.001 | <.001 |
| Lactate dehydrogenase, mU/mL, median (range) | 199 (78-472) | 200 (77-540) | 217 (104-758) | .83 | <.001 | .003 |
| Circulating CD34+ cells, ×106/L, median (range) | 4.1 (0.6-18) | 4 (0-15.3) | 3.4 (0-261.3) | .50 | .037 | .039 |
| Thrombosis at diagnosis, no. (%) | 5 (2.8%) | 33 (7.1%) | 49 (10.5%) | .059 | .082 | .001 |