Patient characteristics of DS-ALL patients and the DCOG non-DS BCP-ALL reference cohort
| . | DS-ALL . | non–DS-ALL . | P . |
|---|---|---|---|
| Number of patients | 653 | 4445 | — |
| Age at diagnosis (range), y | 5.0 (1.2-17.9) | 4.7 (0.1-17.9) | .002 |
| Sex | |||
| Male | 343 | 2431 | — |
| Female | 310 | 2014 | .3 |
| Median initial WBC × 109/L (range) | 10.5 (0.2-459) | 8.8 (0.2-999) | .14 |
| Extramedullary disease | |||
| CNS (%) | 16/624* (2.5) | 98/4258* (2.2) | .69 |
| Lymph nodes (%) | 134/412* (32.5) | 1471/4339* (33.1) | .57 |
| Hepatomegaly (%) | 245/469* (52.2) | 3156/4357* (71) | <.001 |
| Testis (%) | 1/296* (<1%) | 28/4317 (<1%) | .51 |
| Cytogenetic subgroups | |||
| Normal karyotype | 179/444* (40.3) | 45/650* (6.9) | <.001 |
| BCR-ABL1 t(9;22) | 3/444* (0.7) | 93/3898* (2.4) | .02 |
| MLL (11q23) | 2/444* (0.5) | 36/2966* (1.2) | .15 |
| ETV6-RUNX1 t(12;21) | 37/444* (8.3) | 841/3264* (25.8) | <.001 |
| HeH$ | 40/444* (9) | 235/708* (33) | <.001 |
| HeH trisomy 4 and 10 | 18 (4.5) | 100 (42.5) | <.001 |
| HeH, other | 22 (5.5) | 135 (57.5) | <.001 |
| Others | 183 (41.2) | 225/650* (34.6) | .03 |
| 8-y OS | 74% ± 2% | 89% ± 2% | <.001 |
| 8-y EFS | 64% ± 2% | 81% ± 2% | <.001 |
| 8-y CIR | 26% ± 2% | 15% ± 1% | .001 |
| 2-y TRM | 7% ± 1% | 2% ± <1% | <.001 |
| . | DS-ALL . | non–DS-ALL . | P . |
|---|---|---|---|
| Number of patients | 653 | 4445 | — |
| Age at diagnosis (range), y | 5.0 (1.2-17.9) | 4.7 (0.1-17.9) | .002 |
| Sex | |||
| Male | 343 | 2431 | — |
| Female | 310 | 2014 | .3 |
| Median initial WBC × 109/L (range) | 10.5 (0.2-459) | 8.8 (0.2-999) | .14 |
| Extramedullary disease | |||
| CNS (%) | 16/624* (2.5) | 98/4258* (2.2) | .69 |
| Lymph nodes (%) | 134/412* (32.5) | 1471/4339* (33.1) | .57 |
| Hepatomegaly (%) | 245/469* (52.2) | 3156/4357* (71) | <.001 |
| Testis (%) | 1/296* (<1%) | 28/4317 (<1%) | .51 |
| Cytogenetic subgroups | |||
| Normal karyotype | 179/444* (40.3) | 45/650* (6.9) | <.001 |
| BCR-ABL1 t(9;22) | 3/444* (0.7) | 93/3898* (2.4) | .02 |
| MLL (11q23) | 2/444* (0.5) | 36/2966* (1.2) | .15 |
| ETV6-RUNX1 t(12;21) | 37/444* (8.3) | 841/3264* (25.8) | <.001 |
| HeH$ | 40/444* (9) | 235/708* (33) | <.001 |
| HeH trisomy 4 and 10 | 18 (4.5) | 100 (42.5) | <.001 |
| HeH, other | 22 (5.5) | 135 (57.5) | <.001 |
| Others | 183 (41.2) | 225/650* (34.6) | .03 |
| 8-y OS | 74% ± 2% | 89% ± 2% | <.001 |
| 8-y EFS | 64% ± 2% | 81% ± 2% | <.001 |
| 8-y CIR | 26% ± 2% | 15% ± 1% | .001 |
| 2-y TRM | 7% ± 1% | 2% ± <1% | <.001 |
CNS, central nervous system involvement at diagnosis (>5 WBC/μL; CNS-3); HeH$, DS: 52-60 chromosomes, non-DS: 51-60 chromosomes.
Number of patients available for analysis.