Patient characteristics and comparison between long-term and short-term responders
| . | Median (range), number (percentage) . | P . | |
|---|---|---|---|
| LTR (35 points) . | STR (25 points) . | ||
| Age (years) | 71 (66-85) | 71 (66-83) | .94 |
| Sex | |||
| Males | 19 (53%) | 15 (62%) | .50 |
| Females | 16 (47%) | 10 (38%) | |
| Rai stage | |||
| 0-II | 24 (71%) | 18 (69%) | .91 |
| III-IV | 11 (29%) | 7 (31%) | |
| Hemoglobin (g/dL) | 12 (9-16) | 12 (9-15) | 1.00 |
| Platelets (109/mL) | 140 (63-353) | 175 (82-464) | .30 |
| Lymphocytes (109/mL) | 49 (3-230) | 86 (2-222) | .12 |
| β-2-microglobulin (mg/L) | 3.9 (2-8) | 4.8 (2.5-10.2) | .005 |
| IgG (mg/dL) | 729 (180-3560) | 769 (273-2350) | .60 |
| CD3 (103/mL) | 3900 (642-11 822) | 3783 (875-42 750) | .60 |
| BM lymphocytes (%) | 76 (18-94) | 85 (36-96) | .11 |
| IGHV | |||
| Mutated | 11 (33%) | 11 (48%) | .27 |
| Unmutated | 23 (67%) | 11 (52%) | |
| ZAP70 | |||
| Positive | 20 (58%) | 14 (58%) | .99 |
| Negative | 14 (42%) | 11 (42%) | |
| CD38 | |||
| >30% | 17 (47%) | 14 (58%) | .41 |
| <30% | 18 (53%) | 11 (42%) | |
| FISH | |||
| Deletion 13 | 11 (32%) | 4 (15%) | .23 |
| Negative | 6 (18%) | 6 (23%) | .60 |
| Trisomy 12 | 11 (32%) | 2 (8%) | .03 |
| Deletion 11 | 7 (18%) | 7 (31%) | .23 |
| Deletion 17 | 0 (0%) | 6 (23%) | .005 |
| . | Median (range), number (percentage) . | P . | |
|---|---|---|---|
| LTR (35 points) . | STR (25 points) . | ||
| Age (years) | 71 (66-85) | 71 (66-83) | .94 |
| Sex | |||
| Males | 19 (53%) | 15 (62%) | .50 |
| Females | 16 (47%) | 10 (38%) | |
| Rai stage | |||
| 0-II | 24 (71%) | 18 (69%) | .91 |
| III-IV | 11 (29%) | 7 (31%) | |
| Hemoglobin (g/dL) | 12 (9-16) | 12 (9-15) | 1.00 |
| Platelets (109/mL) | 140 (63-353) | 175 (82-464) | .30 |
| Lymphocytes (109/mL) | 49 (3-230) | 86 (2-222) | .12 |
| β-2-microglobulin (mg/L) | 3.9 (2-8) | 4.8 (2.5-10.2) | .005 |
| IgG (mg/dL) | 729 (180-3560) | 769 (273-2350) | .60 |
| CD3 (103/mL) | 3900 (642-11 822) | 3783 (875-42 750) | .60 |
| BM lymphocytes (%) | 76 (18-94) | 85 (36-96) | .11 |
| IGHV | |||
| Mutated | 11 (33%) | 11 (48%) | .27 |
| Unmutated | 23 (67%) | 11 (52%) | |
| ZAP70 | |||
| Positive | 20 (58%) | 14 (58%) | .99 |
| Negative | 14 (42%) | 11 (42%) | |
| CD38 | |||
| >30% | 17 (47%) | 14 (58%) | .41 |
| <30% | 18 (53%) | 11 (42%) | |
| FISH | |||
| Deletion 13 | 11 (32%) | 4 (15%) | .23 |
| Negative | 6 (18%) | 6 (23%) | .60 |
| Trisomy 12 | 11 (32%) | 2 (8%) | .03 |
| Deletion 11 | 7 (18%) | 7 (31%) | .23 |
| Deletion 17 | 0 (0%) | 6 (23%) | .005 |
BM, bone marrow; FISH, fluorescence in situ hybridization; IGHV, immunoglobulin variable heavy chain.