Related nonhematologic AEs (all grades occurring in >2 [15%] of patients in either cohort)
| Patients . | G-CHOP . | G-FC . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 400/400 mg (n = 14) . | 1600/800 mg (n = 14) . | Total (n = 28) . | 400/400 mg (n = 14) . | 1600/800 mg (n = 14) . | Total (n = 28) . | |||||||
| No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | |
| IRR | 9 | 64 | 9 | 64 | 18 | 64 | 10 | 71 | 12 | 86 | 22 | 79 |
| Infections and infestations | 4 | 29 | 8 | 57 | 12 | 43 | 3 | 21 | 6 | 43 | 9 | 32 |
| Constipation | 4 | 29 | 2 | 14 | 6 | 21 | 3 | 21 | 2 | 14 | 5 | 18 |
| Nausea | 6 | 43 | 4 | 29 | 10 | 36 | 5 | 36 | 6 | 43 | 11 | 39 |
| Fatigue | 2 | 14 | 3 | 21 | 5 | 18 | 1 | 7 | 2 | 14 | 3 | 11 |
| Diarrhea | 6 | 43 | 3 | 21 | 9 | 32 | 2 | 14 | 0 | 0 | 2 | 7 |
| Vomiting | 3 | 21 | 1 | 7 | 4 | 14 | 1 | 7 | 1 | 7 | 2 | 7 |
| Dyspepsia | 3 | 21 | 2 | 14 | 5 | 18 | 0 | 0 | 0 | 0 | 0 | 0 |
| Alopecia | 4 | 29 | 3 | 21 | 7 | 25 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mucosal inflammation | 1 | 7 | 3 | 21 | 4 | 14 | 1 | 7 | 1 | 7 | 2 | 7 |
| Headache | 1 | 7 | 1 | 7 | 2 | 7 | 2 | 14 | 3 | 21 | 5 | 18 |
| Pyrexia | 2 | 14 | 1 | 7 | 3 | 11 | 4 | 29 | 1 | 7 | 5 | 18 |
| Asthenia | 0 | 0 | 3 | 21 | 3 | 11 | 3 | 21 | 3 | 21 | 6 | 21 |
| Patients . | G-CHOP . | G-FC . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 400/400 mg (n = 14) . | 1600/800 mg (n = 14) . | Total (n = 28) . | 400/400 mg (n = 14) . | 1600/800 mg (n = 14) . | Total (n = 28) . | |||||||
| No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | |
| IRR | 9 | 64 | 9 | 64 | 18 | 64 | 10 | 71 | 12 | 86 | 22 | 79 |
| Infections and infestations | 4 | 29 | 8 | 57 | 12 | 43 | 3 | 21 | 6 | 43 | 9 | 32 |
| Constipation | 4 | 29 | 2 | 14 | 6 | 21 | 3 | 21 | 2 | 14 | 5 | 18 |
| Nausea | 6 | 43 | 4 | 29 | 10 | 36 | 5 | 36 | 6 | 43 | 11 | 39 |
| Fatigue | 2 | 14 | 3 | 21 | 5 | 18 | 1 | 7 | 2 | 14 | 3 | 11 |
| Diarrhea | 6 | 43 | 3 | 21 | 9 | 32 | 2 | 14 | 0 | 0 | 2 | 7 |
| Vomiting | 3 | 21 | 1 | 7 | 4 | 14 | 1 | 7 | 1 | 7 | 2 | 7 |
| Dyspepsia | 3 | 21 | 2 | 14 | 5 | 18 | 0 | 0 | 0 | 0 | 0 | 0 |
| Alopecia | 4 | 29 | 3 | 21 | 7 | 25 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mucosal inflammation | 1 | 7 | 3 | 21 | 4 | 14 | 1 | 7 | 1 | 7 | 2 | 7 |
| Headache | 1 | 7 | 1 | 7 | 2 | 7 | 2 | 14 | 3 | 21 | 5 | 18 |
| Pyrexia | 2 | 14 | 1 | 7 | 3 | 11 | 4 | 29 | 1 | 7 | 5 | 18 |
| Asthenia | 0 | 0 | 3 | 21 | 3 | 11 | 3 | 21 | 3 | 21 | 6 | 21 |