Table 4

Association of HLA-match on neutrophil recovery, acute and chronic GVHD and leukemia recurrence

Overall HLA-matchNumberOR/ HR (95% CI)P value
Neutrophil recovery*    
 1-allele mismatched vs matched 227 vs 116 0.72 (0.44-1.70) .18 
 2-allele mismatched vs matched 410 vs 116 0.86 (0.54-1.36) .52 
 3-allele mismatched vs matched 464 vs 116 0.56 (0.36-0.88) .01 
 4-allele mismatched vs matched 254 vs 116 0.55 (0.34-0.88) .01 
 5-allele mismatched vs matched 84 vs 116 0.45 (0.25-0.82) .009 
 3-4 allele vs 1-2 allele mismatched 718 vs 637 0.69 (0.55-0.86) .001 
 5-allele vs 1-2 allele mismatched 85 vs 637 0.56 (0.35-0.89) .01 
 5-allele vs 3-4 allele mismatched 85 vs 718 0.81 (0.51-1.29) .38 
Grade 2-4 acute GVHD†    
 1-allele mismatched vs matched 226 vs 117 1.27 (0.83-1.93) .26 
 2-allele mismatched vs matched 410 vs 117 1.45 (0.99-2.12) .06 
 3-allele mismatched vs matched 464 vs 117 1.53 (1.05-2.23) .03 
 4-allele mismatched vs matched 254 vs 117 1.51 (1.00-2.27) .05 
 5-allele mismatched vs matched 85 vs 117 1.49 (0.89-2.49) .13 
 3-4 allele vs 1-2 allele mismatched 718 vs 637 1.09 (0.92-1.32) .31 
 5-allele vs 1-2 allele mismatched 85 vs 637 1.08 (0.72-1.61) .72 
 5-allele vs 3-4 allele mismatched 85 vs 718 0.98 (0.66-1.46) .92 
Chronic GVHD‡    
 1-allele mismatched vs matched 226 vs 117 0.76 (0.47-1.23) .27 
 2-allele mismatched vs matched 410 vs 117 1.16 (0.77-1.75) .48 
 3-allele mismatched vs matched 464 vs 117 1.02 (0.67-1.54) .93 
 4-allele mismatched vs matched 254 vs 117 1.20 (0.80-1.87) .48 
 5-allele mismatched vs matched 85 vs 117 1.27 (0.70-2.31) .27 
 3-4 allele vs 1-2 allele mismatched 718 vs 637 1.07 (0.85-1.34) .59 
 5 allele vs 1-2 allele mismatched 85 vs 637 1.25 (0.75-2.07) .39 
 5 allele vs 3-4 allele mismatched 85 vs 718 1.17 (0.71-1.94) .53 
Relapse§    
 1-allele mismatched vs matched 226 vs 117 0.93 (0.65-1.33) .69 
 2-allele mismatched vs matched 410 vs 117 0.77 (0.55-1.07) .12 
 3-allele mismatched vs matched 464 vs 117 0.75 (0.53-1.05) .09 
 4-allele mismatched vs matched 254 vs 117 0.50 (0.33-0.73) .001 
 5-allele mismatched vs matched 84 vs 117 0.83 (0.50-1.36) .45 
 3-4 allele vs 1-2 allele mismatched 718 vs 637 0.78 (0.64-0.96) .02 
 5 allele vs 1-2 allele mismatched 85 vs 637 1.01 (0.66-1.54) .98 
 5 allele vs 3-4 allele mismatched 85 vs 718 1.28 (0.84-1.97) .25 
Overall HLA-matchNumberOR/ HR (95% CI)P value
Neutrophil recovery*    
 1-allele mismatched vs matched 227 vs 116 0.72 (0.44-1.70) .18 
 2-allele mismatched vs matched 410 vs 116 0.86 (0.54-1.36) .52 
 3-allele mismatched vs matched 464 vs 116 0.56 (0.36-0.88) .01 
 4-allele mismatched vs matched 254 vs 116 0.55 (0.34-0.88) .01 
 5-allele mismatched vs matched 84 vs 116 0.45 (0.25-0.82) .009 
 3-4 allele vs 1-2 allele mismatched 718 vs 637 0.69 (0.55-0.86) .001 
 5-allele vs 1-2 allele mismatched 85 vs 637 0.56 (0.35-0.89) .01 
 5-allele vs 3-4 allele mismatched 85 vs 718 0.81 (0.51-1.29) .38 
Grade 2-4 acute GVHD†    
 1-allele mismatched vs matched 226 vs 117 1.27 (0.83-1.93) .26 
 2-allele mismatched vs matched 410 vs 117 1.45 (0.99-2.12) .06 
 3-allele mismatched vs matched 464 vs 117 1.53 (1.05-2.23) .03 
 4-allele mismatched vs matched 254 vs 117 1.51 (1.00-2.27) .05 
 5-allele mismatched vs matched 85 vs 117 1.49 (0.89-2.49) .13 
 3-4 allele vs 1-2 allele mismatched 718 vs 637 1.09 (0.92-1.32) .31 
 5-allele vs 1-2 allele mismatched 85 vs 637 1.08 (0.72-1.61) .72 
 5-allele vs 3-4 allele mismatched 85 vs 718 0.98 (0.66-1.46) .92 
Chronic GVHD‡    
 1-allele mismatched vs matched 226 vs 117 0.76 (0.47-1.23) .27 
 2-allele mismatched vs matched 410 vs 117 1.16 (0.77-1.75) .48 
 3-allele mismatched vs matched 464 vs 117 1.02 (0.67-1.54) .93 
 4-allele mismatched vs matched 254 vs 117 1.20 (0.80-1.87) .48 
 5-allele mismatched vs matched 85 vs 117 1.27 (0.70-2.31) .27 
 3-4 allele vs 1-2 allele mismatched 718 vs 637 1.07 (0.85-1.34) .59 
 5 allele vs 1-2 allele mismatched 85 vs 637 1.25 (0.75-2.07) .39 
 5 allele vs 3-4 allele mismatched 85 vs 718 1.17 (0.71-1.94) .53 
Relapse§    
 1-allele mismatched vs matched 226 vs 117 0.93 (0.65-1.33) .69 
 2-allele mismatched vs matched 410 vs 117 0.77 (0.55-1.07) .12 
 3-allele mismatched vs matched 464 vs 117 0.75 (0.53-1.05) .09 
 4-allele mismatched vs matched 254 vs 117 0.50 (0.33-0.73) .001 
 5-allele mismatched vs matched 84 vs 117 0.83 (0.50-1.36) .45 
 3-4 allele vs 1-2 allele mismatched 718 vs 637 0.78 (0.64-0.96) .02 
 5 allele vs 1-2 allele mismatched 85 vs 637 1.01 (0.66-1.54) .98 
 5 allele vs 3-4 allele mismatched 85 vs 718 1.28 (0.84-1.97) .25 
*

Adjusted for transplant period: higher likelihood of recovery for transplants in 2005-2010 compared to 2000-2004 (OR 1.41, 95% CI 1.12-1.76, P = .003).

†

Adjusted for patient age and in vivo T-cell depletion: acute GVHD risks were lower for patients >16 years compared to those ≤16 years (HR 0.62, 95% CI 0.50-0.77, P < .0001) and with in vivo T-cell depletion (HR 0.82, 95% CI 0.51-0.74, P < .0001).

‡

Adjusted for TNC and in vivo T-cell depletion: chronic GVHD risks were lower with units containing TNC 3 x 107/kg or higher compared to units containing TNC <3 x 107/kg (HR 0.59, 95% CI 0.45-0.79, P < .001) and with in vivo T-cell depletion (HR 0.65, 95% CI 0.52-0.82, P < .001).

§

Adjusted for disease, disease status, interval from diagnosis to transplant, and TNC: relapse risks were lower for myelodysplastic syndrome (HR 0.32, 95% CI 0.22-0.47, P < .0001) compared to acute myeloid leukemia, and with units containing TNC 3 x 107/kg or higher compared to units containing TNC <3 x 107/kg (HR 0.71, 95% CI 0.54-0.92, P = .009) and when the interval between diagnosis and transplant was >24 months compared to <12 months (HR 0.51, 95% CI 0.37-0.70, P < .0001). Relapse risks were higher for transplants in relapse (HR 5.57, 95% CI 4.25-7.30, P < .0001) and in second remission (HR 2.28, 95% CI 1.69-3.07, P < .0001) compared to transplants in first remission.

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