Characteristics of patients, disease, and transplantation procedures
| Variable . | Transplant year . | |||
|---|---|---|---|---|
| 1972-1999 . | 2000-2009 . | |||
| HLA-identical siblings . | HLA-matched unrelated donors . | HLA-identical siblings . | HLA-matched unrelated donors . | |
| Number of patients (% by period) | 260 (64) | 145 (36) | 211 (54) | 179 (46) |
| Age at diagnosis, no. (%) | ||||
| 0-5 y | 85 (33) | 54 (37) | 54 (26) | 64 (36) |
| 5-10 y | 106 (41) | 68 (47) | 97 (46) | 82 (46) |
| 10-20 y | 61 (23) | 20 (14) | 43 (20) | 27 (15) |
| >20 y | 8 (3) | 3 (2) | 17 (8) | 6 (3) |
| Age at transplant, no. (%) | ||||
| 0-10 y | 117 (45) | 70 (48) | 115 (55) | 100 (56) |
| 10-20 y | 126 (48) | 68 (47) | 73 (35) | 62 (35) |
| >20 y | 17 (7) | 7 (5) | 23 (11) | 17 (9) |
| Sex, no. (%) | ||||
| Female | 116 (45) | 72 (50) | 97 (46) | 90 (50) |
| Male | 143 (55) | 73 (50) | 112 (53) | 89 (50) |
| Unknown | 1 (<1) | 0 (0) | 2 (1) | 0 (0) |
| Donor/recipient sex, no. (%) | ||||
| Female/female | 63 (24) | 40 (28) | 53 (25) | 36 (20) |
| Female/male | 56 (22) | 31 (21) | 62 (29) | 22 (12) |
| Male/female | 51 (20) | 30 (21) | 43 (20) | 48 (27) |
| Male/male | 84 (32) | 39 (27) | 48 (23) | 66 (37) |
| Unknown | 6 (2) | 5 (3) | 5 (2) | 7 (4) |
| Donor/recipient CMV status, no. (%) | ||||
| Negative/negative | 47 (18) | 30 (21) | 19 (9) | 37 (21) |
| Negative/positive | 16 (6) | 19 (13) | 12 (6) | 33 (18) |
| Positive/negative | 15 (6) | 18 (12) | 10 (5) | 11 (6) |
| Positive/positive | 40 (15) | 22 (15) | 86 (41) | 32 (18) |
| Unknown | 142 (55) | 56 (39) | 84 (40) | 66 (37) |
| Bone marrow status before stem cell transplantation, no. (%) | ||||
| AA | 249 (96) | 133 (92) | 193 (91) | 162 (91) |
| MDS/AML | 11 (4) | 12 (8) | 18 (9) | 17 (9) |
| Time from diagnosis to transplant, no. (%) | ||||
| ≤12 mo | 68 (26) | 22 (15) | 89 (42) | 47 (26) |
| >12 mo | 192 (74) | 123 (85) | 122 (58) | 132 (74) |
| Stem cell source, no. (%) | ||||
| BM | 242 (93) | 132 (91) | 140 (66) | 111 (62) |
| PB | 18 (7) | 13 (9) | 71 (34) | 67 (38) |
| Conditioning | ||||
| Missing conditioning, no. (%) | 30 (12) | 13 (9) | 9 (4) | 5 (3) |
| Fludarabine, no. (%) | ||||
| No | 215 (99) | 128 (98) | 90 (45) | 59 (34) |
| Yes | 3 (1) | 3 (2) | 112 (55) | 115 (66) |
| Anti-T serotherapy, no. (%) | ||||
| No | 159 (64) | 43 (30) | 91 (45) | 63 (36) |
| Yes | 59 (24) | 88 (62) | 111 (55) | 111 (64) |
| Unknown | 30 (12) | 12 (8) | — | — |
| Irradiation, no. (%) | ||||
| No | 33 (13) | 11 (8) | 126 (62) | 100 (57) |
| TLI/TAI | 65 (26) | 31 (22) | 1 (<1) | 9 (5) |
| TBI* | 89 (36) | 80 (56) | 11 (5) | 21 (12) |
| No TBI, TLI/TAI unknown | 44 (18) | 14 (10) | 61 (30) | 38 (22) |
| Unknown | 17 (7) | 7 (5) | 3 (1) | 6 (3) |
| Ex-vivo T-cell manipulation, no. (%) | ||||
| No | 132 (53) | 55 (38) | 184 (91) | 142 (82) |
| Yes | 13 (5) | 47 (33) | 11 (5) | 23 (13) |
| Unknown | 103 (42) | 41 (29) | 7 (3) | 9 (5) |
| Variable . | Transplant year . | |||
|---|---|---|---|---|
| 1972-1999 . | 2000-2009 . | |||
| HLA-identical siblings . | HLA-matched unrelated donors . | HLA-identical siblings . | HLA-matched unrelated donors . | |
| Number of patients (% by period) | 260 (64) | 145 (36) | 211 (54) | 179 (46) |
| Age at diagnosis, no. (%) | ||||
| 0-5 y | 85 (33) | 54 (37) | 54 (26) | 64 (36) |
| 5-10 y | 106 (41) | 68 (47) | 97 (46) | 82 (46) |
| 10-20 y | 61 (23) | 20 (14) | 43 (20) | 27 (15) |
| >20 y | 8 (3) | 3 (2) | 17 (8) | 6 (3) |
| Age at transplant, no. (%) | ||||
| 0-10 y | 117 (45) | 70 (48) | 115 (55) | 100 (56) |
| 10-20 y | 126 (48) | 68 (47) | 73 (35) | 62 (35) |
| >20 y | 17 (7) | 7 (5) | 23 (11) | 17 (9) |
| Sex, no. (%) | ||||
| Female | 116 (45) | 72 (50) | 97 (46) | 90 (50) |
| Male | 143 (55) | 73 (50) | 112 (53) | 89 (50) |
| Unknown | 1 (<1) | 0 (0) | 2 (1) | 0 (0) |
| Donor/recipient sex, no. (%) | ||||
| Female/female | 63 (24) | 40 (28) | 53 (25) | 36 (20) |
| Female/male | 56 (22) | 31 (21) | 62 (29) | 22 (12) |
| Male/female | 51 (20) | 30 (21) | 43 (20) | 48 (27) |
| Male/male | 84 (32) | 39 (27) | 48 (23) | 66 (37) |
| Unknown | 6 (2) | 5 (3) | 5 (2) | 7 (4) |
| Donor/recipient CMV status, no. (%) | ||||
| Negative/negative | 47 (18) | 30 (21) | 19 (9) | 37 (21) |
| Negative/positive | 16 (6) | 19 (13) | 12 (6) | 33 (18) |
| Positive/negative | 15 (6) | 18 (12) | 10 (5) | 11 (6) |
| Positive/positive | 40 (15) | 22 (15) | 86 (41) | 32 (18) |
| Unknown | 142 (55) | 56 (39) | 84 (40) | 66 (37) |
| Bone marrow status before stem cell transplantation, no. (%) | ||||
| AA | 249 (96) | 133 (92) | 193 (91) | 162 (91) |
| MDS/AML | 11 (4) | 12 (8) | 18 (9) | 17 (9) |
| Time from diagnosis to transplant, no. (%) | ||||
| ≤12 mo | 68 (26) | 22 (15) | 89 (42) | 47 (26) |
| >12 mo | 192 (74) | 123 (85) | 122 (58) | 132 (74) |
| Stem cell source, no. (%) | ||||
| BM | 242 (93) | 132 (91) | 140 (66) | 111 (62) |
| PB | 18 (7) | 13 (9) | 71 (34) | 67 (38) |
| Conditioning | ||||
| Missing conditioning, no. (%) | 30 (12) | 13 (9) | 9 (4) | 5 (3) |
| Fludarabine, no. (%) | ||||
| No | 215 (99) | 128 (98) | 90 (45) | 59 (34) |
| Yes | 3 (1) | 3 (2) | 112 (55) | 115 (66) |
| Anti-T serotherapy, no. (%) | ||||
| No | 159 (64) | 43 (30) | 91 (45) | 63 (36) |
| Yes | 59 (24) | 88 (62) | 111 (55) | 111 (64) |
| Unknown | 30 (12) | 12 (8) | — | — |
| Irradiation, no. (%) | ||||
| No | 33 (13) | 11 (8) | 126 (62) | 100 (57) |
| TLI/TAI | 65 (26) | 31 (22) | 1 (<1) | 9 (5) |
| TBI* | 89 (36) | 80 (56) | 11 (5) | 21 (12) |
| No TBI, TLI/TAI unknown | 44 (18) | 14 (10) | 61 (30) | 38 (22) |
| Unknown | 17 (7) | 7 (5) | 3 (1) | 6 (3) |
| Ex-vivo T-cell manipulation, no. (%) | ||||
| No | 132 (53) | 55 (38) | 184 (91) | 142 (82) |
| Yes | 13 (5) | 47 (33) | 11 (5) | 23 (13) |
| Unknown | 103 (42) | 41 (29) | 7 (3) | 9 (5) |
Abbreviations: AA, aplastic anemia; CMV, cytomegalovirus; MDS, myelodysplastic syndrome; PB, peripheral blood stem cells; TAI, thoracoabdominal irradiation; TBI, total body irradiation; TLI, total lymphoid irradiation.
Doses for TBI were missing for 93/208 patients. Seven patients received 2 Gray, 94 received between 4 and 6 Gray, and 10 patients received 7 Gray or more.