Table 1 Selected series comparing... | American Society of Hematology

Table 1

Selected series comparing myeloablative single unit UCBT with transplantation of adult donors in adults

Series	Patients, n	Conditioning	Graft source	Median Age (years)	DFS, %	Comment
Takahashi, Blood 2007,⁹⁵ hematologic malignancy	71		UCB	38	70	UCB similar or superior to matched sibling donor transplant
	55 BM	Myelo	MRD	40	60
	6 PBSC	Ablative
Atsuta, Blood 2009,⁹⁶ acute leukemia	287		UCB
	173 AML	Myelo		38	42
	114 ALL	Ablative		34	46	UCB similar to MUD in ALL
	533		MUD			UCB inferior in AML (higher TRM)
	311 AML			38	54
	222 ALL			32	44
Eapen, Lancet 2010,⁶⁵ acute leukemia	165		UCB	28	44	UCB and MUD comparable; disease status only factor associated with DFS
	888	Myelo	PBSC	39	50
	623	Ablative	MUD
	265		MMUD
	472		BM	33	52
	332		MUD
	140		MMUD

Series	Patients, n	Conditioning	Graft source	Median Age (years)	DFS, %	Comment
Takahashi, Blood 2007,⁹⁵ hematologic malignancy	71		UCB	38	70	UCB similar or superior to matched sibling donor transplant
	55 BM	Myelo	MRD	40	60
	6 PBSC	Ablative
Atsuta, Blood 2009,⁹⁶ acute leukemia	287		UCB
	173 AML	Myelo		38	42
	114 ALL	Ablative		34	46	UCB similar to MUD in ALL
	533		MUD			UCB inferior in AML (higher TRM)
	311 AML			38	54
	222 ALL			32	44
Eapen, Lancet 2010,⁶⁵ acute leukemia	165		UCB	28	44	UCB and MUD comparable; disease status only factor associated with DFS
	888	Myelo	PBSC	39	50
	623	Ablative	MUD
	265		MMUD
	472		BM	33	52
	332		MUD
	140		MMUD

ALL, acute lymphoid leukemia; AML, acute myeloid leukemia; PBSC, peripheral blood stem cell.