Mechanisms of microbiota and host communication to regulate hematopoiesis
| Reference . | Mouse model . | Antibiotics . | Treatment duration, wk . | Microbiota mechanism . | Host mechanism . |
|---|---|---|---|---|---|
| 7 | GF/ABX | Vancomycin | 4-5 | MAMPs | Not discussed |
| Ampicillin | |||||
| Neomycin | |||||
| Streptomycin | |||||
| 6 | GF/ABX | Vancomycin | 4 | Heat-killed microbial product | Signaling through MyD88/TICAM1 |
| Ampicillin | |||||
| Neomycin | |||||
| Metronidazole | |||||
| 8 | ABX | Vancomycin | 2 | Not discussed | Signaling through STAT1 |
| Ampicillin | |||||
| Neomycin | |||||
| Metronidazole | |||||
| 9 | GF | N/A | NOD1 ligand | Production of HSPC proliferation-stimulating cytokines by MSCs | |
| N/A | |||||
| Reference . | Mouse model . | Antibiotics . | Treatment duration, wk . | Microbiota mechanism . | Host mechanism . |
|---|---|---|---|---|---|
| 7 | GF/ABX | Vancomycin | 4-5 | MAMPs | Not discussed |
| Ampicillin | |||||
| Neomycin | |||||
| Streptomycin | |||||
| 6 | GF/ABX | Vancomycin | 4 | Heat-killed microbial product | Signaling through MyD88/TICAM1 |
| Ampicillin | |||||
| Neomycin | |||||
| Metronidazole | |||||
| 8 | ABX | Vancomycin | 2 | Not discussed | Signaling through STAT1 |
| Ampicillin | |||||
| Neomycin | |||||
| Metronidazole | |||||
| 9 | GF | N/A | NOD1 ligand | Production of HSPC proliferation-stimulating cytokines by MSCs | |
| N/A | |||||
ABX, antibiotics; MAMPs, microbe-associated molecular patterns; MSCs, mesenchymal stromal cells; N/A, not applicable.