Revised International Staging System for MM
| R-ISS stage . | Criteria . |
|---|---|
| I | All of the following: |
| Serum albumin ≥3.5 g/dL | |
| Serum β2-microglobulin <3.5 mg/L | |
| No high-risk CA* | |
| Normal serum LDH level | |
| II | Not R-ISS stage I or III |
| III | Both of the following: |
| Serum β2-microglobulin ≥5.5 mg/L | |
| High-risk CA by iFISH or high LDH |
| R-ISS stage . | Criteria . |
|---|---|
| I | All of the following: |
| Serum albumin ≥3.5 g/dL | |
| Serum β2-microglobulin <3.5 mg/L | |
| No high-risk CA* | |
| Normal serum LDH level | |
| II | Not R-ISS stage I or III |
| III | Both of the following: |
| Serum β2-microglobulin ≥5.5 mg/L | |
| High-risk CA by iFISH or high LDH |
Adapted from Palumbo et al with permission.28
CA, chromosomal abnormalities; iFISH, interphase FISH.
High-risk CA: presence of del(17p) and/or translocation t(4;14) and/or translocation t(14;16).