Relationship of individual cytokines with clinical and laboratory manifestations of KSHV-MCD
| Clinical manifestation . | Human and viral cytokine prediction models . | ||
|---|---|---|---|
| Predictor(s) . | Model . | Adjusted R2 for model prediction vs actual value . | |
| Fever (temperature, °C) | hIL-6 | T = 36.9 + 0.019 (hIL-6) | 0.26 |
| Respiratory symptoms* | hIL-6 | Predicted to be present if hIL-6 ≥ 17.74 | NA (correctly predicted symptom presence or absence in 70.4% of cases: 25/33 [76%] without and 13/21 [62%] with) |
| Gastrointestinal symptoms* | hIL-6 | Predicted to be present if hIL-6 ≥ 19.55 | NA (correctly predicted symptoms presence or absence in 77.8% of cases: [77.8%] 27/31 [87%] without and 15/23 [65%] with) |
| Laboratory manifestation | |||
| Hemoglobin | hIL-6 with vIL-6† | Hb = 12.7 − 0.025(hIL-6) − 0.69(vIL-6)† | 0.30 |
| Platelets | hIL-6 | Plt = 202 − 1.35(hIL-6) | 0.15 |
| Sodium | hIL-6 with vIL-6 and IL-10† | Na = 139.9 − 0.0577(h-IL-6) + 0.0002(IL-10) − 2.77(vIL-6)† | 0.47 |
| Albumin | IL-1β with vIL-6† | Alb = 3.88 − 0.21(IL-1β) − 0.33(vIL-6)† | 0.33 |
| Clinical manifestation . | Human and viral cytokine prediction models . | ||
|---|---|---|---|
| Predictor(s) . | Model . | Adjusted R2 for model prediction vs actual value . | |
| Fever (temperature, °C) | hIL-6 | T = 36.9 + 0.019 (hIL-6) | 0.26 |
| Respiratory symptoms* | hIL-6 | Predicted to be present if hIL-6 ≥ 17.74 | NA (correctly predicted symptom presence or absence in 70.4% of cases: 25/33 [76%] without and 13/21 [62%] with) |
| Gastrointestinal symptoms* | hIL-6 | Predicted to be present if hIL-6 ≥ 19.55 | NA (correctly predicted symptoms presence or absence in 77.8% of cases: [77.8%] 27/31 [87%] without and 15/23 [65%] with) |
| Laboratory manifestation | |||
| Hemoglobin | hIL-6 with vIL-6† | Hb = 12.7 − 0.025(hIL-6) − 0.69(vIL-6)† | 0.30 |
| Platelets | hIL-6 | Plt = 202 − 1.35(hIL-6) | 0.15 |
| Sodium | hIL-6 with vIL-6 and IL-10† | Na = 139.9 − 0.0577(h-IL-6) + 0.0002(IL-10) − 2.77(vIL-6)† | 0.47 |
| Albumin | IL-1β with vIL-6† | Alb = 3.88 − 0.21(IL-1β) − 0.33(vIL-6)† | 0.33 |