Clinical and laboratory manifestations of KSHV-MCD
| . | Flares . | Remissions* . | ||
|---|---|---|---|---|
| Episodes (patients) | 34 (21) | 20 (20) | ||
| Number of symptoms present† (median, range) | 4 (2-8) | 0 | ||
| Most severe symptom grade present‡ (median, range) | 2 (1-3) | 0 | ||
| Clinical manifestations | N present (% flares) | CTC grade (median, range) | N present (% remissions) | CTC grade (median, range) |
| Fever (temperature abnormal if >38.3°C) | 21 (61.8) | 1 (0-3)§ | 0 | — |
| Sweats or rigors | 23 (67.6) | 1 (0-2) | 0 | — |
| Fatigue | 31 (91.2) | 2 (2-3) | 2 (10) | 0 (0-1) |
| Respiratory | 21 (61.8) | 1 (0-2) | 0 | — |
| Gastrointestinal | 23 (67.6) | 1 (0-3) | 0 | — |
| Neurological | 8 (23.5) | 0 (0-1) | 1 (5) | 0 (0-1) |
| Rheumatological | 4 (11.8) | 0 (0-1) | 0 | — |
| Dermatological | 4 (11.8) | 0 (0-1) | 0 | — |
| Laboratory manifestations | N abnormal (% flares) | Value (median, range) | N abnormal (% remissions) | Value (median, range) |
| Hemoglobin (g/dL) | 33 (97) | 9.9 (6.8-14.4) | 12 (60) | 12.7 (10.5-15.4) |
| (abnormal if <13.7 g/dL) | ||||
| Platelets (103 cells/μL) | 23 (67.6) | 100 (6-567) | 3 (15) | 198 (91-338) |
| (abnormal if <161 × 103 cells/μL) | ||||
| Leukocytes (103 cells/μL)‖ | 11 (32.6) | 5.4 (1.0-63.3) | 7 (35) | 4.7 (1.7-11.5) |
| (abnormal if <4.23 × 103 cells/μL) | ||||
| Sodium (mmol/L) | 23 (67.6) | 133 (127-143) | 1 (5) | 138 (133-144) |
| (abnormal if <135 mmol/L) | ||||
| Albumin (g/dL) | 33 (97) | 2.7 (1.2-3.9) | 2 (10) | 3.9 (3.2-4.4) |
| (abnormal if <3.7 mg/dL) | ||||
| HIV parameters | N present (% flares) | Value (median, range) | N present (% remissions) | Value (median, range) |
| Receiving combination antiretroviral therapy | 32 (94) | — | 20 (100) | — |
| CD4 count (cells/μL) | — | 252 (24-1319) | — | 367 (129-872) |
| HIV VL (copies/mL) | — | <50 (<50-64 100) | — | <50 (50-1150) |
| HIV VL (<50 copies/mL) | 24 (71) | — | 16 (80) | — |
| . | Flares . | Remissions* . | ||
|---|---|---|---|---|
| Episodes (patients) | 34 (21) | 20 (20) | ||
| Number of symptoms present† (median, range) | 4 (2-8) | 0 | ||
| Most severe symptom grade present‡ (median, range) | 2 (1-3) | 0 | ||
| Clinical manifestations | N present (% flares) | CTC grade (median, range) | N present (% remissions) | CTC grade (median, range) |
| Fever (temperature abnormal if >38.3°C) | 21 (61.8) | 1 (0-3)§ | 0 | — |
| Sweats or rigors | 23 (67.6) | 1 (0-2) | 0 | — |
| Fatigue | 31 (91.2) | 2 (2-3) | 2 (10) | 0 (0-1) |
| Respiratory | 21 (61.8) | 1 (0-2) | 0 | — |
| Gastrointestinal | 23 (67.6) | 1 (0-3) | 0 | — |
| Neurological | 8 (23.5) | 0 (0-1) | 1 (5) | 0 (0-1) |
| Rheumatological | 4 (11.8) | 0 (0-1) | 0 | — |
| Dermatological | 4 (11.8) | 0 (0-1) | 0 | — |
| Laboratory manifestations | N abnormal (% flares) | Value (median, range) | N abnormal (% remissions) | Value (median, range) |
| Hemoglobin (g/dL) | 33 (97) | 9.9 (6.8-14.4) | 12 (60) | 12.7 (10.5-15.4) |
| (abnormal if <13.7 g/dL) | ||||
| Platelets (103 cells/μL) | 23 (67.6) | 100 (6-567) | 3 (15) | 198 (91-338) |
| (abnormal if <161 × 103 cells/μL) | ||||
| Leukocytes (103 cells/μL)‖ | 11 (32.6) | 5.4 (1.0-63.3) | 7 (35) | 4.7 (1.7-11.5) |
| (abnormal if <4.23 × 103 cells/μL) | ||||
| Sodium (mmol/L) | 23 (67.6) | 133 (127-143) | 1 (5) | 138 (133-144) |
| (abnormal if <135 mmol/L) | ||||
| Albumin (g/dL) | 33 (97) | 2.7 (1.2-3.9) | 2 (10) | 3.9 (3.2-4.4) |
| (abnormal if <3.7 mg/dL) | ||||
| HIV parameters | N present (% flares) | Value (median, range) | N present (% remissions) | Value (median, range) |
| Receiving combination antiretroviral therapy | 32 (94) | — | 20 (100) | — |
| CD4 count (cells/μL) | — | 252 (24-1319) | — | 367 (129-872) |
| HIV VL (copies/mL) | — | <50 (<50-64 100) | — | <50 (50-1150) |
| HIV VL (<50 copies/mL) | 24 (71) | — | 16 (80) | — |
Any abnormalities noted in remission were not attributable to KSHV-MCD.
Number of clinical manifestations of KSHV-MCD present; includes fever and symptoms scored in organ systems but not laboratory abnormalities.
Most severe symptom attributable to KSHV-MCD present, scored using Common Toxicity Criteria for Adverse Events, version 3.0.
Temperature 38.0°C (range 36.1-40.5).
Leukocytes were not considered in the definition of biochemical responses.