Distribution of aCL IgG (GPL units) and aCL IgM (MPL units) among LAC-positive and LAC-negative patients
| aCL variable . | LAC negative (n = 2121) . | P (95% CI) LAC-negative vs LAC-negative subgroup . | LAC-negative subgroup (n = 340) . | LAC positive (n = 62) . | P (95% CI) LAC-positive vs LAC-negative subgroup . |
|---|---|---|---|---|---|
| Mean (median) GPL | 10.8 (9.3) | .485** | 11.0 (9.3) | 33.1 | <.001** |
| n < 15 GPL (%) | 1972 (93.0) | .962 (−0.028 to 0.030) | 316 (92.9) | 19 (30.6) | <.001 (0.515-0.721) |
| n > 40 GPL (%)* | 16 (0.8) | .893 (−0.011 to 0.009) | 3 (0.9) | 28 (45.2) | <.001 (0.370-0.516) |
| Mean (median) MPL | 12.8 (9.8) | .649** | 13.2 (9.7) | 37.5 (22.5) | <.001** |
| n < 25 MPL (%) | 2047 (96.5) | .686 (−0.027 to 0.015) | 330 (97.1) | 37 (59.7) | <.001 (0.225-0.411) |
| n > 40 MPL (%)* | 29 (1.4) | .918 (−0.015 to 0.013) | 5 (1.5) | 17 (27.4) | <.001 (0.197-0.321) |
| aCL variable . | LAC negative (n = 2121) . | P (95% CI) LAC-negative vs LAC-negative subgroup . | LAC-negative subgroup (n = 340) . | LAC positive (n = 62) . | P (95% CI) LAC-positive vs LAC-negative subgroup . |
|---|---|---|---|---|---|
| Mean (median) GPL | 10.8 (9.3) | .485** | 11.0 (9.3) | 33.1 | <.001** |
| n < 15 GPL (%) | 1972 (93.0) | .962 (−0.028 to 0.030) | 316 (92.9) | 19 (30.6) | <.001 (0.515-0.721) |
| n > 40 GPL (%)* | 16 (0.8) | .893 (−0.011 to 0.009) | 3 (0.9) | 28 (45.2) | <.001 (0.370-0.516) |
| Mean (median) MPL | 12.8 (9.8) | .649** | 13.2 (9.7) | 37.5 (22.5) | <.001** |
| n < 25 MPL (%) | 2047 (96.5) | .686 (−0.027 to 0.015) | 330 (97.1) | 37 (59.7) | <.001 (0.225-0.411) |
| n > 40 MPL (%)* | 29 (1.4) | .918 (−0.015 to 0.013) | 5 (1.5) | 17 (27.4) | <.001 (0.197-0.321) |
Less than 15 GPL or 25 MPL is considered negative in our laboratory. GPL or MPL units greater than 40 fulfill APS criteria.10 P values are given comparing the LAC-positive group vs the LAC-negative subgroup. The LAC subgroup was representative of the entire group of LAC-negative patients, as there were no statistical differences between median aCL levels or prevalence of aCL-positive patients. In contrast, all aCL variables were significantly different between the LAC-negative subgroup and the LAC-positive group.
Fulfills classification criteria for APS; **Mann-Whitney rank-sum test.