CD37 and CD20 staining on paraffin-embedded lymphoma tissue cores by IHC
| Indication . | Histological subtype . | Percentage of positive cores . | n . | |
|---|---|---|---|---|
| CD37 . | CD20 . | |||
| B-cell NHL | Follicular lymphoma | 100 | 100 | 3 |
| DLBCL | 93 | 93 | 14 | |
| MALT lymphoma | 100 | 100 | 3 | |
| Burkitt lymphoma | 75 | 88 | 8 | |
| Mantle cell lymphoma | 90 | 100 | 29 | |
| Unspecified NHL | 95 | 95 | 22 | |
| CLL | 100 | 100 | 3 | |
| Multiple myeloma | 0 | 0 | 10 | |
| T-cell lymphoma | 0 | 0 | 3 | |
| Indication . | Histological subtype . | Percentage of positive cores . | n . | |
|---|---|---|---|---|
| CD37 . | CD20 . | |||
| B-cell NHL | Follicular lymphoma | 100 | 100 | 3 |
| DLBCL | 93 | 93 | 14 | |
| MALT lymphoma | 100 | 100 | 3 | |
| Burkitt lymphoma | 75 | 88 | 8 | |
| Mantle cell lymphoma | 90 | 100 | 29 | |
| Unspecified NHL | 95 | 95 | 22 | |
| CLL | 100 | 100 | 3 | |
| Multiple myeloma | 0 | 0 | 10 | |
| T-cell lymphoma | 0 | 0 | 3 | |
IHC studies were conducted with an anti-CD37 antibody (clone CT1, 4 µg/mL; Novocastra) and an anti-CD20 antibody (clone L26, 0.5 µg/mL; DAKO) compared with isotype controls (Beckman Coulter). Staining results were scored by a board certified pathologist. Staining intensity scoring: 0 = negative; 1 = weak; 2 = moderate; and 3 = strong. Positive staining was defined as a score of ≥2.
MALT, mucosa-associated lymphoid tissue.