Baseline characteristics of patients in the study
| Variable . | Baseline distribution in cohort . | |
|---|---|---|
| Sample | ||
| Sample size for sequencing | 738 | |
| Sample size with outcome data | 595 | |
| Median (range) follow-up | 12 (0-155) months | |
| Demographics | ||
| Sex | ||
| Male | 415 (56%) | |
| Female | 323 (44%) | |
| Age, mean ± SD | 68 ± 13 years | |
| MDS classification | Total | With outcome data |
| RA | 139 (19%) | 109 |
| RARS | 92 (12%) | 75 |
| RARS-T | 17 (2%) | 17 |
| RCMD | 126 (17%) | 99 |
| RCMD-RS | 59 (8%) | 58 |
| RAEB | 167 (23%) | 138 |
| 5q- | 20 (3%) | 16 |
| CMML | 70 (9%) | 61 |
| MDS-MPN | 3 (0.4%) | 1 |
| MDS-U | 10 (1%) | 1 |
| MDS-AML | 35 (5%) | 20 |
| Blood counts at diagnosis | ||
| Hemoglobin level, mean ± SD | 9.9 ± 2.0 g/dL | |
| Neutrophil count, mean ± SD | 3.0 ± 3.4 × 109 per liter | |
| Platelet count, mean ± SD | 191 ± 181 × 109 per liter | |
| Bone marrow features | ||
| Ring sideroblasts > 15% | 173/529 (33%); missing for 209 patients | |
| Bone marrow blasts > 5% | 202 (27%) | |
| Karyotype | ||
| Normal | 425 | |
| Abnormal | 213 | |
| Failed/not done | 100 | |
| Outcome | ||
| Leukemic transformation | 66/595 (11%) | |
| Died | 234/595 (39%) | |
| Variable . | Baseline distribution in cohort . | |
|---|---|---|
| Sample | ||
| Sample size for sequencing | 738 | |
| Sample size with outcome data | 595 | |
| Median (range) follow-up | 12 (0-155) months | |
| Demographics | ||
| Sex | ||
| Male | 415 (56%) | |
| Female | 323 (44%) | |
| Age, mean ± SD | 68 ± 13 years | |
| MDS classification | Total | With outcome data |
| RA | 139 (19%) | 109 |
| RARS | 92 (12%) | 75 |
| RARS-T | 17 (2%) | 17 |
| RCMD | 126 (17%) | 99 |
| RCMD-RS | 59 (8%) | 58 |
| RAEB | 167 (23%) | 138 |
| 5q- | 20 (3%) | 16 |
| CMML | 70 (9%) | 61 |
| MDS-MPN | 3 (0.4%) | 1 |
| MDS-U | 10 (1%) | 1 |
| MDS-AML | 35 (5%) | 20 |
| Blood counts at diagnosis | ||
| Hemoglobin level, mean ± SD | 9.9 ± 2.0 g/dL | |
| Neutrophil count, mean ± SD | 3.0 ± 3.4 × 109 per liter | |
| Platelet count, mean ± SD | 191 ± 181 × 109 per liter | |
| Bone marrow features | ||
| Ring sideroblasts > 15% | 173/529 (33%); missing for 209 patients | |
| Bone marrow blasts > 5% | 202 (27%) | |
| Karyotype | ||
| Normal | 425 | |
| Abnormal | 213 | |
| Failed/not done | 100 | |
| Outcome | ||
| Leukemic transformation | 66/595 (11%) | |
| Died | 234/595 (39%) | |
MDS-U, undefined MDS category; RAEB, refractory anemia with excess blasts; SD, standard deviation.